Human Gene HLA-F (ENST00000259951.12) from GENCODE V44
Description: Homo sapiens major histocompatibility complex, class I, F (HLA-F), transcript variant 1, mRNA. (from RefSeq NM_001098479) RefSeq Summary (NM_001098479): This gene belongs to the HLA class I heavy chain paralogues. It encodes a non-classical heavy chain that forms a heterodimer with a beta-2 microglobulin light chain, with the heavy chain anchored in the membrane. Unlike most other HLA heavy chains, this molecule is localized in the endoplasmic reticulum and Golgi apparatus, with a small amount present at the cell surface in some cell types. It contains a divergent peptide-binding groove, and is thought to bind a restricted subset of peptides for immune presentation. This gene exhibits few polymorphisms. Multiple transcript variants encoding different isoforms have been found for this gene. These variants lack a coding exon found in transcripts from other HLA paralogues due to an altered splice acceptor site, resulting in a shorter cytoplasmic domain. [provided by RefSeq, Jul 2008]. Gencode Transcript: ENST00000259951.12 Gencode Gene: ENSG00000204642.14 Transcript (Including UTRs) Position: hg38 chr6:29,723,434-29,727,296 Size: 3,863 Total Exon Count: 7 Strand: + Coding Region Position: hg38 chr6:29,723,464-29,727,175 Size: 3,712 Coding Exon Count: 7
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF07654 - Immunoglobulin C1-set domain PF00129 - Class I Histocompatibility antigen, domains alpha 1 and 2
ModBase Predicted Comparative 3D Structure on Q5JZ48
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Cellular Component: GO:0016020 membrane GO:0016021 integral component of membrane
Descriptions from all associated GenBank mRNAs
AK300090 - Homo sapiens cDNA FLJ60056 complete cds, highly similar to HLA class I histocompatibility antigen, alpha chain F precursor. AK302420 - Homo sapiens cDNA FLJ53112 complete cds, highly similar to HLA class I histocompatibility antigen, alpha chain F precursor. BC009260 - Homo sapiens major histocompatibility complex, class I, F, mRNA (cDNA clone IMAGE:4039990), partial cds. AK309156 - Homo sapiens cDNA, FLJ99197. AK303670 - Homo sapiens cDNA FLJ53123 complete cds. AK298704 - Homo sapiens cDNA FLJ60325 complete cds, highly similar to HLA class I histocompatibility antigen, alpha chain F precursor. AK125274 - Homo sapiens cDNA FLJ43284 fis, clone LYMPB2000083, highly similar to HLA CLASS I HISTOCOMPATIBILITY ANTIGEN, ALPHA CHAIN F PRECURSOR. AK096962 - Homo sapiens cDNA FLJ39643 fis, clone SMINT2004023, highly similar to HLA class I histocompatibility antigen, alphachain F precursor. AK225185 - Homo sapiens mRNA for major histocompatibility complex, class I, F precursor variant, clone: COL01957. AK301488 - Homo sapiens cDNA FLJ54780 complete cds, highly similar to HLA class I histocompatibility antigen, alpha chain F precursor. JD019958 - Sequence 982 from Patent EP1572962. BC062991 - Homo sapiens major histocompatibility complex, class I, F, mRNA (cDNA clone MGC:74962 IMAGE:5496696), complete cds. CU687616 - Synthetic construct Homo sapiens gateway clone IMAGE:100021717 5' read HLA-F mRNA. KJ896984 - Synthetic construct Homo sapiens clone ccsbBroadEn_06378 HLA-F gene, encodes complete protein. KJ896983 - Synthetic construct Homo sapiens clone ccsbBroadEn_06377 HLA-F gene, encodes complete protein. AB590981 - Synthetic construct DNA, clone: pFN21AE1907, Homo sapiens HLA-F gene for major histocompatibility complex, class I, F, without stop codon, in Flexi system. AY253269 - Homo sapiens MHC class Ib antigen (HLA-F) mRNA, HLA-F*0101 variant 1 allele, complete cds. AY253270 - Homo sapiens MHC class Ib antigen (HLA-F) mRNA, HLA-F*0101 variant 2 allele, complete cds. AY253271 - Homo sapiens MHC class Ib antigen (HLA-F) mRNA, HLA-F*0101 variant 3 allele, complete cds. DQ367723 - Homo sapiens MHC class I antigen (HLA-F) mRNA, complete cds. GQ891552 - Homo sapiens MHC class I antigen (HLA-F) mRNA, HLA-F*0109 allele, complete cds. AY216682 - Homo sapiens nonclassical MHC class I antigen (HLA-F) mRNA, HLA-F*0101 variant allele, partial cds. AY221102 - Homo sapiens MHC class I antigen (HLA-F) mRNA, partial cds. JD030687 - Sequence 11711 from Patent EP1572962. JD470849 - Sequence 451873 from Patent EP1572962. MA870118 - JP 2018536436-A/1954: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA869741 - JP 2018536436-A/1577: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA870106 - JP 2018536436-A/1942: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA869740 - JP 2018536436-A/1576: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA870105 - JP 2018536436-A/1941: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA869312 - JP 2018536436-A/1148: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA869690 - JP 2018536436-A/1526: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA869313 - JP 2018536436-A/1149: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA869689 - JP 2018536436-A/1525: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA870052 - JP 2018536436-A/1888: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA869314 - JP 2018536436-A/1150: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA869688 - JP 2018536436-A/1524: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA870051 - JP 2018536436-A/1887: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA869315 - JP 2018536436-A/1151: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA869687 - JP 2018536436-A/1523: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA870050 - JP 2018536436-A/1886: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA869316 - JP 2018536436-A/1152: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA869686 - JP 2018536436-A/1522: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA870049 - JP 2018536436-A/1885: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA869317 - JP 2018536436-A/1153: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA869685 - JP 2018536436-A/1521: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA870048 - JP 2018536436-A/1884: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA869318 - JP 2018536436-A/1154: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA870047 - JP 2018536436-A/1883: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA869331 - JP 2018536436-A/1167: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA869333 - JP 2018536436-A/1169: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA869334 - JP 2018536436-A/1170: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA870034 - JP 2018536436-A/1870: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA869335 - JP 2018536436-A/1171: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA869336 - JP 2018536436-A/1172: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA869673 - JP 2018536436-A/1509: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA869672 - JP 2018536436-A/1508: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA870031 - JP 2018536436-A/1867: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA869347 - JP 2018536436-A/1183: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA869663 - JP 2018536436-A/1499: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA869348 - JP 2018536436-A/1184: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA869662 - JP 2018536436-A/1498: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA869661 - JP 2018536436-A/1497: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA869660 - JP 2018536436-A/1496: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA869977 - JP 2018536436-A/1813: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA869393 - JP 2018536436-A/1229: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA869614 - JP 2018536436-A/1450: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY592530 - KR 1020180133840-A/1954: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY592153 - KR 1020180133840-A/1577: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY592518 - KR 1020180133840-A/1942: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY592152 - KR 1020180133840-A/1576: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY592517 - KR 1020180133840-A/1941: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY591724 - KR 1020180133840-A/1148: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY592102 - KR 1020180133840-A/1526: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY591725 - KR 1020180133840-A/1149: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY592101 - KR 1020180133840-A/1525: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY592464 - KR 1020180133840-A/1888: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY591726 - KR 1020180133840-A/1150: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY592100 - KR 1020180133840-A/1524: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY592463 - KR 1020180133840-A/1887: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY591727 - KR 1020180133840-A/1151: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY592099 - KR 1020180133840-A/1523: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY592462 - KR 1020180133840-A/1886: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY591728 - KR 1020180133840-A/1152: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY592098 - KR 1020180133840-A/1522: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY592461 - KR 1020180133840-A/1885: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY591729 - KR 1020180133840-A/1153: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY592097 - KR 1020180133840-A/1521: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY592460 - KR 1020180133840-A/1884: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY591730 - KR 1020180133840-A/1154: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY592459 - KR 1020180133840-A/1883: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY591743 - KR 1020180133840-A/1167: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY591745 - KR 1020180133840-A/1169: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY591746 - KR 1020180133840-A/1170: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY592446 - KR 1020180133840-A/1870: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY591747 - KR 1020180133840-A/1171: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY591748 - KR 1020180133840-A/1172: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY592085 - KR 1020180133840-A/1509: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY592084 - KR 1020180133840-A/1508: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY592443 - KR 1020180133840-A/1867: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY591759 - KR 1020180133840-A/1183: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY592075 - KR 1020180133840-A/1499: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY591760 - KR 1020180133840-A/1184: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY592074 - KR 1020180133840-A/1498: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY592073 - KR 1020180133840-A/1497: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY592072 - KR 1020180133840-A/1496: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY592389 - KR 1020180133840-A/1813: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY591805 - KR 1020180133840-A/1229: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY592026 - KR 1020180133840-A/1450: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
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