Human Gene RPS18 (ENST00000439602.7) from GENCODE V44
Description: Homo sapiens ribosomal protein S18 (RPS18), mRNA. (from RefSeq NM_022551) RefSeq Summary (NM_022551): Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S13P family of ribosomal proteins. It is located in the cytoplasm. The gene product of the E. coli ortholog (ribosomal protein S13) is involved in the binding of fMet-tRNA, and thus, in the initiation of translation. This gene is an ortholog of mouse Ke3. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]. Gencode Transcript: ENST00000439602.7 Gencode Gene: ENSG00000231500.7 Transcript (Including UTRs) Position: hg38 chr6:33,272,075-33,276,511 Size: 4,437 Total Exon Count: 6 Strand: + Coding Region Position: hg38 chr6:33,272,120-33,276,466 Size: 4,347 Coding Exon Count: 6
ID:RS18_HUMAN DESCRIPTION: RecName: Full=40S ribosomal protein S18; AltName: Full=Ke-3; Short=Ke3; FUNCTION: Located at the top of the head of the 40S subunit, it contacts several helices of the 18S rRNA (By similarity). SUBCELLULAR LOCATION: Cytoplasm. SIMILARITY: Belongs to the ribosomal protein S13P family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P62269
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
BC106063 - Homo sapiens ribosomal protein S18, mRNA (cDNA clone MGC:117351 IMAGE:4386992), complete cds. X69150 - Homo sapiens mRNA for ribosomal protein S18. BC070230 - Homo sapiens cDNA clone IMAGE:6654805, partial cds. AB055778 - Homo sapiens mRNA for ribosomal protein S18, partial cds. BC101786 - Homo sapiens ribosomal protein S18, mRNA (cDNA clone MGC:126835 IMAGE:8069292), complete cds. BC101788 - Homo sapiens ribosomal protein S18, mRNA (cDNA clone MGC:126837 IMAGE:8069294), complete cds. AY536376 - Homo sapiens rhabdomyosarcoma antigen MU-RMS-40.21 (RPS18) mRNA, complete cds, alternatively spliced. JD129150 - Sequence 110174 from Patent EP1572962. BC071936 - Homo sapiens cDNA clone IMAGE:4125298, **** WARNING: chimeric clone ****. JD394525 - Sequence 375549 from Patent EP1572962. AB590711 - Synthetic construct DNA, clone: pFN21AE2148, Homo sapiens RPS18 gene for ribosomal protein S18, without stop codon, in Flexi system. KJ892062 - Synthetic construct Homo sapiens clone ccsbBroadEn_01456 RPS18 gene, encodes complete protein. DL489932 - Novel nucleic acids. DQ585261 - Homo sapiens piRNA piR-52373, complete sequence. JD216801 - Sequence 197825 from Patent EP1572962. DL490902 - Novel nucleic acids. DQ582219 - Homo sapiens piRNA piR-32331, complete sequence. LF366729 - JP 2014500723-A/174232: Polycomb-Associated Non-Coding RNAs. MA602306 - JP 2018138019-A/174232: Polycomb-Associated Non-Coding RNAs. LF369575 - JP 2014500723-A/177078: Polycomb-Associated Non-Coding RNAs. MA605152 - JP 2018138019-A/177078: Polycomb-Associated Non-Coding RNAs. DL490386 - Novel nucleic acids.
Biochemical and Signaling Pathways
KEGG - Kyoto Encyclopedia of Genes and Genomes hsa03010 - Ribosome
Reactome (by CSHL, EBI, and GO)
Protein P62269 (Reactome details) participates in the following event(s):
R-HSA-72676 eIF3 and eIF1A bind to the 40S subunit R-HSA-72673 Release of 40S and 60S subunits from the 80S ribosome R-HSA-72672 The 60S subunit joins the translation initiation complex R-HSA-72619 eIF2:GTP is hydrolyzed, eIFs are released R-HSA-72691 Formation of the 43S pre-initiation complex R-HSA-156808 Formation of translation initiation complexes yielding circularized Ceruloplasmin mRNA in a 'closed-loop' conformation R-HSA-157849 Formation of translation initiation complexes containing mRNA that does not circularize R-HSA-72671 eIF5B:GTP is hydrolyzed and released R-HSA-156907 Aminoacyl-tRNA binds to the ribosome at the A-site R-HSA-2408529 Sec-tRNA(Sec):EEFSEC:GTP binds to 80S Ribosome R-HSA-141691 GTP bound eRF3:eRF1 complex binds the peptidyl tRNA:mRNA:80S Ribosome complex R-HSA-156915 Translocation of ribosome by 3 bases in the 3' direction R-HSA-141671 Polypeptide release from the eRF3-GDP:eRF1:mRNA:80S Ribosome complex R-HSA-156912 Peptide transfer from P-site tRNA to the A-site tRNA R-HSA-927832 UPF1 binds an mRNP with a termination codon preceding an Exon Junction Complex R-HSA-927789 Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex R-HSA-1799332 Nascent polypeptide:mRNA:ribosome complex binds signal recognition particle (SRP) R-HSA-156923 Hydrolysis of eEF1A:GTP R-HSA-72621 Ribosomal scanning R-HSA-72697 Start codon recognition R-HSA-156823 Association of phospho-L13a with GAIT element of Ceruloplasmin mRNA R-HSA-5333615 80S:Met-tRNAi:mRNA:SECISBP2:Sec-tRNA(Sec):EEFSEC:GTP is hydrolysed to 80S:Met-tRNAi:mRNA:SECISBP2:Sec and EEFSEC:GDP by EEFSEC R-HSA-141673 GTP Hydrolysis by eRF3 bound to the eRF1:mRNA:polypeptide:80S Ribosome complex R-HSA-927889 SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) R-HSA-1799329 Signal peptidase hydrolyzes signal peptide from ribosome-associated nascent protein R-HSA-1799330 The SRP receptor binds the SRP:nascent peptide:ribosome complex R-HSA-1799326 Signal-containing nascent peptide translocates to endoplasmic reticulum R-HSA-72689 Formation of a pool of free 40S subunits R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-1799339 SRP-dependent cotranslational protein targeting to membrane R-HSA-9010553 Regulation of expression of SLITs and ROBOs R-HSA-72706 GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72695 Formation of the ternary complex, and subsequently, the 43S complex R-HSA-72649 Translation initiation complex formation R-HSA-72737 Cap-dependent Translation Initiation R-HSA-8868773 rRNA processing in the nucleus and cytosol R-HSA-156902 Peptide chain elongation R-HSA-2408557 Selenocysteine synthesis R-HSA-72764 Eukaryotic Translation Termination R-HSA-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-HSA-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-72766 Translation R-HSA-376176 Signaling by ROBO receptors R-HSA-192823 Viral mRNA Translation R-HSA-72702 Ribosomal scanning and start codon recognition R-HSA-156827 L13a-mediated translation R-HSA-72662 Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S R-HSA-72613 Eukaryotic Translation Initiation R-HSA-72312 rRNA processing R-HSA-156842 Eukaryotic Translation Elongation R-HSA-2408522 Selenoamino acid metabolism R-HSA-927802 Nonsense-Mediated Decay (NMD) R-HSA-392499 Metabolism of proteins R-HSA-422475 Axon guidance R-HSA-168273 Influenza Viral RNA Transcription and Replication R-HSA-8953854 Metabolism of RNA R-HSA-71291 Metabolism of nitrogenous molecules R-HSA-1266738 Developmental Biology R-HSA-168255 Influenza Life Cycle R-HSA-1430728 Metabolism R-HSA-168254 Influenza Infection R-HSA-5663205 Infectious disease R-HSA-1643685 Disease
US Server
