Human Gene FGD2 (ENST00000489356.1) from GENCODE V44
  Description: FYVE, RhoGEF and PH domain containing 2 (from HGNC FGD2)
RefSeq Summary (NM_173558): The protein encoded by this gene belongs to a family of guanine nucleotide exchange factors (GEFs) which control cytoskeleton-dependent membrane rearrangements by activating the cell division cycle 42 (CDC42) protein. This gene is expressed in B lymphocytes, macrophages, and dendritic cells. The encoded protein may play a role in leukocyte signaling and vesicle trafficking in antigen-presenting cells in the immune system. [provided by RefSeq, Oct 2016].
Gencode Transcript: ENST00000489356.1
Gencode Gene: ENSG00000146192.15
Transcript (Including UTRs)
   Position: hg38 chr6:37,005,646-37,010,031 Size: 4,386 Total Exon Count: 2 Strand: +


Page IndexSequence and LinksPrimersCTDRNA-Seq ExpressionMicroarray Expression
Other SpeciesmRNA DescriptionsOther NamesMethods
Data last updated at UCSC: 2023-08-18 00:09:47

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr6:37,005,646-37,010,031)mRNA (may differ from genome)No protein
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
EnsemblExonPrimerGencodeHGNCLynxPubMed
Wikipedia

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 93.24 RPKM in Spleen
Total median expression: 296.24 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
      
      
      
      
      

-  Descriptions from all associated GenBank mRNAs
  BC062363 - Homo sapiens FYVE, RhoGEF and PH domain containing 2, mRNA (cDNA clone IMAGE:5440975), with apparent retained intron.
BC023645 - Homo sapiens FYVE, RhoGEF and PH domain containing 2, mRNA (cDNA clone MGC:29450 IMAGE:5087501), complete cds.
GQ900971 - Homo sapiens clone HEL-T-83 epididymis secretory sperm binding protein mRNA, complete cds.
AK290419 - Homo sapiens cDNA FLJ75636 complete cds, highly similar to Homo sapiens FYVE, RhoGEF and PH domain containing 2, mRNA.
AK301156 - Homo sapiens cDNA FLJ61425 complete cds, highly similar to FYVE, RhoGEF and PH domain-containing protein2.
AK300964 - Homo sapiens cDNA FLJ58428 complete cds, highly similar to FYVE, RhoGEF and PH domain-containing protein 2.
AK092732 - Homo sapiens cDNA FLJ35413 fis, clone SMINT2000602, highly similar to Faciogenital dysplasia protein 2.
AX747694 - Sequence 1219 from Patent EP1308459.
AK024456 - Homo sapiens mRNA for FLJ00048 protein, partial cds.
JD039962 - Sequence 20986 from Patent EP1572962.
BC053655 - Homo sapiens FYVE, RhoGEF and PH domain containing 2, mRNA (cDNA clone MGC:61693 IMAGE:5755893), complete cds.
BX648164 - Homo sapiens mRNA; cDNA DKFZp686H1440 (from clone DKFZp686H1440).
JD273509 - Sequence 254533 from Patent EP1572962.
JD447787 - Sequence 428811 from Patent EP1572962.
KJ904034 - Synthetic construct Homo sapiens clone ccsbBroadEn_13428 FGD2 gene, encodes complete protein.
DQ893612 - Synthetic construct clone IMAGE:100006242; FLH182471.01X; RZPDo839G07138D FYVE, RhoGEF and PH domain containing 2 (FGD2) gene, encodes complete protein.
DQ894928 - Synthetic construct Homo sapiens clone IMAGE:100009388; FLH182467.01L; RZPDo839G07137D FYVE, RhoGEF and PH domain containing 2 (FGD2) gene, encodes complete protein.
JD475659 - Sequence 456683 from Patent EP1572962.
JD422814 - Sequence 403838 from Patent EP1572962.
JD229671 - Sequence 210695 from Patent EP1572962.
JD453737 - Sequence 434761 from Patent EP1572962.
JD374752 - Sequence 355776 from Patent EP1572962.
JD117518 - Sequence 98542 from Patent EP1572962.
JD523782 - Sequence 504806 from Patent EP1572962.
JD430658 - Sequence 411682 from Patent EP1572962.
JD557773 - Sequence 538797 from Patent EP1572962.
JD530802 - Sequence 511826 from Patent EP1572962.
JD171512 - Sequence 152536 from Patent EP1572962.
JD047412 - Sequence 28436 from Patent EP1572962.
JD047413 - Sequence 28437 from Patent EP1572962.
JD085600 - Sequence 66624 from Patent EP1572962.
JD518382 - Sequence 499406 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: BC062363, uc003onf.1, uc003onf.2, uc003onf.3, uc003onf.4
UCSC ID: ENST00000489356.1
RefSeq Accession: NM_173558

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.