Human Gene MAD2L1BP (ENST00000372171.5) from GENCODE V44
Description: Homo sapiens MAD2L1 binding protein (MAD2L1BP), transcript variant 2, mRNA. (from RefSeq NM_014628) RefSeq Summary (NM_014628): The protein encoded by this gene was identified as a binding protein of the MAD2 mitotic arrest deficient-like 1 (MAD2/MAD2L1). MAD2 is a key component of the spindle checkpoint that delays the onset of anaphase until all the kinetochores are attached to the spindle. This protein may interact with the spindle checkpoint and coordinate cell cycle events in late mitosis. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]. Gencode Transcript: ENST00000372171.5 Gencode Gene: ENSG00000124688.14 Transcript (Including UTRs) Position: hg38 chr6:43,635,840-43,640,941 Size: 5,102 Total Exon Count: 3 Strand: + Coding Region Position: hg38 chr6:43,635,876-43,640,533 Size: 4,658 Coding Exon Count: 3
ID:MD2BP_HUMAN DESCRIPTION: RecName: Full=MAD2L1-binding protein; AltName: Full=Caught by MAD2 protein; FUNCTION: May function to silence the spindle checkpoint and allow mitosis to proceed through anaphase by binding MAD2L1 after it has become dissociated from the MAD2L1-CDC20 complex. SUBUNIT: Interacts with MAD2L1. INTERACTION: Q13257:MAD2L1; NbExp=4; IntAct=EBI-712181, EBI-78203; Q15645:TRIP13; NbExp=5; IntAct=EBI-712181, EBI-358993; SUBCELLULAR LOCATION: Nucleus. Cytoplasm, cytoskeleton, spindle. Note=During early mitosis, unevenly distributed throughout the nucleoplasm. From metaphase to anaphase, concentrated on the spindle. DEVELOPMENTAL STAGE: During the cell cycle, levels increase and then remain constant until late mitosis after which they drop. PTM: Phosphorylated upon DNA damage, probably by ATM or ATR. SIMILARITY: Belongs to the MAD2L1BP family. SEQUENCE CAUTION: Sequence=BAG59665.1; Type=Erroneous initiation;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q15013
Front
Top
Side
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.