Human Gene POU3F2 (ENST00000328345.8) from GENCODE V44
Description: Homo sapiens POU class 3 homeobox 2 (POU3F2), mRNA. (from RefSeq NM_005604) RefSeq Summary (NM_005604): This gene encodes a member of the POU-III class of neural transcription factors. The encoded protein is involved in neuronal differentiation and enhances the activation of corticotropin-releasing hormone regulated genes. Overexpression of this protein is associated with an increase in the proliferation of melanoma cells. [provided by RefSeq, Mar 2012]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Gencode Transcript: ENST00000328345.8 Gencode Gene: ENSG00000184486.10 Transcript (Including UTRs) Position: hg38 chr6:98,834,574-98,839,458 Size: 4,885 Total Exon Count: 1 Strand: + Coding Region Position: hg38 chr6:98,834,874-98,836,205 Size: 1,332 Coding Exon Count: 1
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF00046 - Homeobox domain PF00157 - Pou domain - N-terminal to homeobox domain
ModBase Predicted Comparative 3D Structure on P20265
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding GO:0001105 RNA polymerase II transcription coactivator activity GO:0003677 DNA binding GO:0003700 transcription factor activity, sequence-specific DNA binding GO:0005515 protein binding GO:0042802 identical protein binding GO:0043565 sequence-specific DNA binding
Biological Process: GO:0006351 transcription, DNA-templated GO:0006355 regulation of transcription, DNA-templated GO:0006357 regulation of transcription from RNA polymerase II promoter GO:0006366 transcription from RNA polymerase II promoter GO:0007399 nervous system development GO:0007420 brain development GO:0008284 positive regulation of cell proliferation GO:0008544 epidermis development GO:0010629 negative regulation of gene expression GO:0014002 astrocyte development GO:0014044 Schwann cell development GO:0021799 cerebral cortex radially oriented cell migration GO:0021869 forebrain ventricular zone progenitor cell division GO:0021979 hypothalamus cell differentiation GO:0021985 neurohypophysis development GO:0022011 myelination in peripheral nervous system GO:0030154 cell differentiation GO:0030182 neuron differentiation GO:0040018 positive regulation of multicellular organism growth GO:0045595 regulation of cell differentiation GO:0045944 positive regulation of transcription from RNA polymerase II promoter GO:0048663 neuron fate commitment GO:0048665 neuron fate specification GO:0048666 neuron development GO:0050770 regulation of axonogenesis GO:0071310 cellular response to organic substance
US Server
