Human Gene CDC40 (ENST00000368932.5) from GENCODE V44
Description: Associates with the spliceosome late in the splicing pathway and may function in the second step of pre-mRNA splicing. (from UniProt O60508) RefSeq Summary (NM_015891): Pre-mRNA splicing occurs in two sequential transesterification steps. The protein encoded by this gene is found to be essential for the catalytic step II in pre-mRNA splicing process. It is found in the spliceosome, and contains seven WD repeats, which function in protein-protein interactions. This protein has a sequence similarity to yeast Prp17 protein, which functions in two different cellular processes: pre-mRNA splicing and cell cycle progression. It suggests that this protein may play a role in cell cycle progression. [provided by RefSeq, Jul 2008]. Gencode Transcript: ENST00000368932.5 Gencode Gene: ENSG00000168438.15 Transcript (Including UTRs) Position: hg38 chr6:110,180,141-110,232,223 Size: 52,083 Total Exon Count: 16 Strand: + Coding Region Position: hg38 chr6:110,180,445-110,230,131 Size: 49,687 Coding Exon Count: 15
ID:PRP17_HUMAN DESCRIPTION: RecName: Full=Pre-mRNA-processing factor 17; AltName: Full=Cell division cycle 40 homolog; AltName: Full=EH-binding protein 3; Short=Ehb3; AltName: Full=PRP17 homolog; Short=hPRP17; FUNCTION: Associates with the spliceosome late in the splicing pathway and may function in the second step of pre-mRNA splicing. SUBUNIT: Identified in the spliceosome C complex. SUBCELLULAR LOCATION: Nucleus. SIMILARITY: Contains 7 WD repeats. SEQUENCE CAUTION: Sequence=AAC25166.1; Type=Erroneous initiation;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on O60508
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
BC117145 - Homo sapiens cell division cycle 40 homolog (S. cerevisiae), mRNA (cDNA clone MGC:150754 IMAGE:40125696), complete cds. BC126114 - Homo sapiens cell division cycle 40 homolog (S. cerevisiae), mRNA (cDNA clone MGC:161392 IMAGE:8991830), complete cds. BC018059 - Homo sapiens cDNA clone IMAGE:4811841, **** WARNING: chimeric clone ****. AB208903 - Homo sapiens mRNA for pre-mRNA splicing factor 17 variant protein. AK001426 - Homo sapiens cDNA FLJ10564 fis, clone NT2RP2002928, highly similar to Homo sapiens pre-mRNA splicing factor mRNA. BC111061 - Homo sapiens cell division cycle 40 homolog (S. cerevisiae), mRNA (cDNA clone IMAGE:5744210), complete cds. AF038392 - Homo sapiens pre-mRNA splicing factor (PRP17) mRNA, complete cds. AK314601 - Homo sapiens cDNA, FLJ95438, Homo sapiens cell division cycle 40 homolog (yeast) (CDC40), mRNA. AK222721 - Homo sapiens mRNA for pre-mRNA splicing factor 17 variant, clone: COL08147. AK295055 - Homo sapiens cDNA FLJ61258 complete cds, highly similar to Pre-mRNA-splicing factor PRP17. AB528038 - Synthetic construct DNA, clone: pF1KB9989, Homo sapiens CDC40 gene for Pre-mRNA-processing factor 17, without stop codon, in Flexi system. HQ258473 - Synthetic construct Homo sapiens clone IMAGE:100072902 cell division cycle 40 homolog (S. cerevisiae) (CDC40) (CDC40) gene, encodes complete protein. AF061241 - Homo sapiens splicing factor hPRP17 mRNA, complete cds. AF015044 - Homo sapiens EH-binding protein mRNA, partial cds. JD102056 - Sequence 83080 from Patent EP1572962. JD432524 - Sequence 413548 from Patent EP1572962. JD180237 - Sequence 161261 from Patent EP1572962. JD199522 - Sequence 180546 from Patent EP1572962. JD179167 - Sequence 160191 from Patent EP1572962.
Biochemical and Signaling Pathways
KEGG - Kyoto Encyclopedia of Genes and Genomes hsa03040 - Spliceosome
Reactome (by CSHL, EBI, and GO)
Protein O60508 (Reactome details) participates in the following event(s):
R-HSA-72124 Formation of the Spliceosomal A Complex R-HSA-75096 Docking of the TAP:EJC Complex with the NPC R-HSA-72143 Lariat Formation and 5'-Splice Site Cleavage R-HSA-72139 Formation of the active Spliceosomal C (B*) complex R-HSA-72127 Formation of the Spliceosomal B Complex R-HSA-72130 Formation of an intermediate Spliceosomal C (Bact) complex R-HSA-8849157 TREX complex binds spliced, capped mRNA:CBC:EJC cotranscriptionally R-HSA-72185 mRNA polyadenylation R-HSA-72180 Cleavage of mRNA at the 3'-end R-HSA-156661 Formation of Exon Junction Complex R-HSA-159101 NXF1:NXT1 (TAP:p15) binds capped mRNA:CBC:EJC:TREX (minus DDX39B) R-HSA-72163 mRNA Splicing - Major Pathway R-HSA-159236 Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-72187 mRNA 3'-end processing R-HSA-109688 Cleavage of Growing Transcript in the Termination Region R-HSA-72172 mRNA Splicing R-HSA-72202 Transport of Mature Transcript to Cytoplasm R-HSA-72203 Processing of Capped Intron-Containing Pre-mRNA R-HSA-73856 RNA Polymerase II Transcription Termination R-HSA-8953854 Metabolism of RNA R-HSA-73857 RNA Polymerase II Transcription R-HSA-74160 Gene expression (Transcription)
US Server
