Human Gene ZUP1 (ENST00000368576.8) from GENCODE V44
Description: Homo sapiens zinc finger containing ubiquitin peptidase 1 (ZUP1), transcript variant 8, non-coding RNA. (from RefSeq NR_154589) RefSeq Summary (NM_145062): This gene encodes a protein containing zinc finger motifs and a cysteine peptidase domain. The encoded protein functions as a K63-specific de-ubiquitinating enzyme that specifically cleaves long K63-linked polyubiquitin chains in the middle of a chain (i.e. 'endo cleavage) rather than by removing the terminal ubiquitin from a chain. This enzyme is thought to be involved in the regulation of DNA repair by cleaving K63-linked ubiquitin chains at repair foci. This protein is related to proteases for the ubiquitin-like modifiers Ufm1 (ubiquitin fold modifier 1) and Atg8/Gabarapl2, but does not have any activity on these modifiers. [provided by RefSeq, Mar 2018]. Gencode Transcript: ENST00000368576.8 Gencode Gene: ENSG00000153975.10 Transcript (Including UTRs) Position: hg38 chr6:116,635,618-116,668,766 Size: 33,149 Total Exon Count: 10 Strand: - Coding Region Position: hg38 chr6:116,635,832-116,667,192 Size: 31,361 Coding Exon Count: 9
ID:ZUFSP_HUMAN DESCRIPTION: RecName: Full=Zinc finger with UFM1-specific peptidase domain protein; SIMILARITY: Contains 3 C2H2-type zinc fingers. CAUTION: Although related to the Ufm1-specific proteases, it lacks the conserved His active site, suggesting that it is probably inactive. SEQUENCE CAUTION: Sequence=CAI20499.1; Type=Erroneous gene model prediction;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q96AP4
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
