Human Gene CDCA7L (ENST00000356195.9) from GENCODE V44
  Description: Homo sapiens cell division cycle associated 7 like (CDCA7L), transcript variant 2, mRNA. (from RefSeq NM_001127370)
Gencode Transcript: ENST00000356195.9
Gencode Gene: ENSG00000164649.20
Transcript (Including UTRs)
   Position: hg38 chr7:21,900,900-21,945,878 Size: 44,979 Total Exon Count: 11 Strand: -
Coding Region
   Position: hg38 chr7:21,902,322-21,916,816 Size: 14,495 Coding Exon Count: 9 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesMethods
Data last updated at UCSC: 2023-08-18 00:09:47

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr7:21,900,900-21,945,878)mRNA (may differ from genome)Protein (420 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGencodeGeneCards
HGNCLynxMalacardsMGIneXtProtOMIM
PubMedUniProtKBWikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: CDA7L_HUMAN
DESCRIPTION: RecName: Full=Cell division cycle-associated 7-like protein; AltName: Full=Protein JPO2; AltName: Full=Transcription factor RAM2;
FUNCTION: Plays a role in transcriptional regulation as a repressor that inhibits monoamine oxidase A (MAOA) activity and gene expression by binding to the promoter. Plays an important oncogenic role in mediating the full transforming effect of MYC in medulloblastoma cells. Involved in apoptotic signaling pathways; May act downstream of P38-kinase and BCL-2, but upstream of CASP3/caspase-3 as well as CCND1/cyclin D1 and E2F1.
SUBUNIT: Interacts with MYC and PSIP1.
SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Note=Associates with chromatin. Translocates from cytoplasm to nucleus under dexamethasone induction.
TISSUE SPECIFICITY: Ubiquitous. Overexpressed in medulloblastoma.
INDUCTION: By MYC overexpression in a concentration dependent manner in neuroblastoma cell line.
MISCELLANEOUS: Cells lacking CDCA7L display a reduction of 25-30% of colony formation in medulloblastoma cell lines. CDCA7L overexpression induces colony formation.
SEQUENCE CAUTION: Sequence=BAB14330.1; Type=Frameshift; Positions=260;

-  Primer design for this transcript
 

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Click here to load the transcript sequence and exon structure into Primer3Plus

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Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: CDCA7L
Diseases sorted by gene-association score: medulloblastoma (17)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 12.09 RPKM in Cells - EBV-transformed lymphocytes
Total median expression: 162.93 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -74.90230-0.326 Picture PostScript Text
3' UTR -399.801422-0.281 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR018866 - Znf-4CXXC_R1

Pfam Domains:
PF10497 - Zinc-finger domain of monoamine-oxidase A repressor R1

ModBase Predicted Comparative 3D Structure on Q96GN5
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserGenome BrowserNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
MGIRGDEnsembl   
Protein SequenceProtein SequenceProtein Sequence   
AlignmentAlignmentAlignment   

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005515 protein binding

Biological Process:
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0008284 positive regulation of cell proliferation

Cellular Component:
GO:0001650 fibrillar center
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005829 cytosol


-  Descriptions from all associated GenBank mRNAs
  BC014630 - Homo sapiens cell division cycle associated 7-like, mRNA (cDNA clone IMAGE:3344091), partial cds.
BC009352 - Homo sapiens cell division cycle associated 7-like, mRNA (cDNA clone MGC:15015 IMAGE:4139111), complete cds.
LP896474 - Sequence 1338 from Patent EP3253886.
AK095965 - Homo sapiens cDNA FLJ38646 fis, clone HHDPC2006460, highly similar to Homo sapiens cell division cycle associated 7-like (CDCA7L), mRNA.
AK022955 - Homo sapiens cDNA FLJ12893 fis, clone NT2RP2004165.
AL359619 - Homo sapiens mRNA; cDNA DKFZp762L0311 (from clone DKFZp762L0311).
BC039823 - Homo sapiens cell division cycle associated 7-like, mRNA (cDNA clone MGC:48716 IMAGE:6057601), complete cds.
BC025242 - Homo sapiens cell division cycle associated 7-like, mRNA (cDNA clone MGC:39098 IMAGE:4842169), complete cds.
BC032576 - Homo sapiens cell division cycle associated 7-like, mRNA (cDNA clone MGC:44909 IMAGE:5491780), complete cds.
JD100831 - Sequence 81855 from Patent EP1572962.
JD225691 - Sequence 206715 from Patent EP1572962.
JD536066 - Sequence 517090 from Patent EP1572962.
JD383313 - Sequence 364337 from Patent EP1572962.
JD145516 - Sequence 126540 from Patent EP1572962.
JD534721 - Sequence 515745 from Patent EP1572962.
JD086385 - Sequence 67409 from Patent EP1572962.
JD047897 - Sequence 28921 from Patent EP1572962.
JD302810 - Sequence 283834 from Patent EP1572962.
JD434133 - Sequence 415157 from Patent EP1572962.
JD094915 - Sequence 75939 from Patent EP1572962.
JD185063 - Sequence 166087 from Patent EP1572962.
JD116555 - Sequence 97579 from Patent EP1572962.
JD041748 - Sequence 22772 from Patent EP1572962.
JD490942 - Sequence 471966 from Patent EP1572962.
JD345068 - Sequence 326092 from Patent EP1572962.
JD398616 - Sequence 379640 from Patent EP1572962.
JD240073 - Sequence 221097 from Patent EP1572962.
JD521111 - Sequence 502135 from Patent EP1572962.
JD095439 - Sequence 76463 from Patent EP1572962.
JD213184 - Sequence 194208 from Patent EP1572962.
JD533913 - Sequence 514937 from Patent EP1572962.
JD407612 - Sequence 388636 from Patent EP1572962.
JD152283 - Sequence 133307 from Patent EP1572962.
JD399336 - Sequence 380360 from Patent EP1572962.
JD322127 - Sequence 303151 from Patent EP1572962.
JD213183 - Sequence 194207 from Patent EP1572962.
JD293160 - Sequence 274184 from Patent EP1572962.
JD234106 - Sequence 215130 from Patent EP1572962.
JD428265 - Sequence 409289 from Patent EP1572962.
JD528150 - Sequence 509174 from Patent EP1572962.
JD291302 - Sequence 272326 from Patent EP1572962.
JD500962 - Sequence 481986 from Patent EP1572962.
JD457147 - Sequence 438171 from Patent EP1572962.
JD550046 - Sequence 531070 from Patent EP1572962.
JD234105 - Sequence 215129 from Patent EP1572962.
JD234104 - Sequence 215128 from Patent EP1572962.
JD550266 - Sequence 531290 from Patent EP1572962.
JD428264 - Sequence 409288 from Patent EP1572962.
JD528149 - Sequence 509173 from Patent EP1572962.
JD181538 - Sequence 162562 from Patent EP1572962.
JD162959 - Sequence 143983 from Patent EP1572962.
JD402109 - Sequence 383133 from Patent EP1572962.
JD429133 - Sequence 410157 from Patent EP1572962.
JD540886 - Sequence 521910 from Patent EP1572962.
AK292490 - Homo sapiens cDNA FLJ76447 complete cds, highly similar to Homo sapiens cell division cycle associated 7-like (CDCA7L), mRNA.
AK300781 - Homo sapiens cDNA FLJ54095 complete cds, highly similar to Homo sapiens cell division cycle associated 7-like (CDCA7L), mRNA.
JD235198 - Sequence 216222 from Patent EP1572962.
JD200825 - Sequence 181849 from Patent EP1572962.
JD237476 - Sequence 218500 from Patent EP1572962.
JD184397 - Sequence 165421 from Patent EP1572962.
JD038278 - Sequence 19302 from Patent EP1572962.
AY161168 - Homo sapiens transcription factor RAM2 splice variant b mRNA, complete cds; alternatively spliced.
AY161169 - Homo sapiens transcription factor RAM2 splice variant c mRNA, complete cds; alternatively spliced.
HQ448527 - Synthetic construct Homo sapiens clone IMAGE:100071962; CCSB011304_03 cell division cycle associated 7-like (CDCA7L) gene, encodes complete protein.
KJ902829 - Synthetic construct Homo sapiens clone ccsbBroadEn_12223 CDCA7L gene, encodes complete protein.
AB463479 - Synthetic construct DNA, clone: pF1KB7777, Homo sapiens CDCA7L gene for cell division cycle associated 7-like, without stop codon, in Flexi system.
JD057706 - Sequence 38730 from Patent EP1572962.
CU692942 - Synthetic construct Homo sapiens gateway clone IMAGE:100023082 5' read CDCA7L mRNA.
CU691768 - Synthetic construct Homo sapiens gateway clone IMAGE:100021148 5' read CDCA7L mRNA.
DQ586389 - Homo sapiens piRNA piR-53501, complete sequence.
JD144209 - Sequence 125233 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: A4D141, A6NF50, B3KTR5, CDA7L_HUMAN, ENST00000356195.1, ENST00000356195.2, ENST00000356195.3, ENST00000356195.4, ENST00000356195.5, ENST00000356195.6, ENST00000356195.7, ENST00000356195.8, HR1, JPO2, NM_001127370, Q6PIL4, Q86YT0, Q8IXN5, Q96C70, Q96GN5, Q9H9A2, Q9NPV2, R1, uc003sve.1, uc003sve.2, uc003sve.3, uc003sve.4, uc003sve.5
UCSC ID: ENST00000356195.9
RefSeq Accession: NM_001127370
Protein: Q96GN5 (aka CDA7L_HUMAN)
CCDS: CCDS47559.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.