ID:CDA7L_HUMAN DESCRIPTION: RecName: Full=Cell division cycle-associated 7-like protein; AltName: Full=Protein JPO2; AltName: Full=Transcription factor RAM2; FUNCTION: Plays a role in transcriptional regulation as a repressor that inhibits monoamine oxidase A (MAOA) activity and gene expression by binding to the promoter. Plays an important oncogenic role in mediating the full transforming effect of MYC in medulloblastoma cells. Involved in apoptotic signaling pathways; May act downstream of P38-kinase and BCL-2, but upstream of CASP3/caspase-3 as well as CCND1/cyclin D1 and E2F1. SUBUNIT: Interacts with MYC and PSIP1. SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Note=Associates with chromatin. Translocates from cytoplasm to nucleus under dexamethasone induction. TISSUE SPECIFICITY: Ubiquitous. Overexpressed in medulloblastoma. INDUCTION: By MYC overexpression in a concentration dependent manner in neuroblastoma cell line. MISCELLANEOUS: Cells lacking CDCA7L display a reduction of 25-30% of colony formation in medulloblastoma cell lines. CDCA7L overexpression induces colony formation. SEQUENCE CAUTION: Sequence=BAB14330.1; Type=Frameshift; Positions=260;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF10497 - Zinc-finger domain of monoamine-oxidase A repressor R1
ModBase Predicted Comparative 3D Structure on Q96GN5
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.