Human Gene NOD1 (ENST00000222823.9) from GENCODE V44
Description: Homo sapiens nucleotide binding oligomerization domain containing 1 (NOD1), transcript variant 1, mRNA. (from RefSeq NM_006092) RefSeq Summary (NM_006092): This gene encodes a member of the nucleotide-binding oligomerization domain (NOD)-like receptor (NLR) family of proteins. The encoded protein plays a role in innate immunity by acting as a pattern-recognition receptor (PRR) that binds bacterial peptidoglycans and initiates inflammation. This protein has also been implicated in the immune response to viral and parasitic infection. Major structural features of this protein include an N-terminal caspase recruitment domain (CARD), a centrally located nucleotide-binding domain (NBD), and 10 tandem leucine-rich repeats (LRRs) in its C terminus. The CARD is involved in apoptotic signaling, LRRs participate in protein-protein interactions, and mutations in the NBD may affect the process of oligomerization and subsequent function of the LRR domain. Mutations in this gene are associated with asthma, inflammatory bowel disease, Behcet disease and sarcoidosis in human patients. [provided by RefSeq, Aug 2017]. Gencode Transcript: ENST00000222823.9 Gencode Gene: ENSG00000106100.11 Transcript (Including UTRs) Position: hg38 chr7:30,424,527-30,478,784 Size: 54,258 Total Exon Count: 14 Strand: - Coding Region Position: hg38 chr7:30,425,638-30,456,921 Size: 31,284 Coding Exon Count: 11
ID:NOD1_HUMAN DESCRIPTION: RecName: Full=Nucleotide-binding oligomerization domain-containing protein 1; AltName: Full=Caspase recruitment domain-containing protein 4; FUNCTION: Enhances caspase-9-mediated apoptosis. Induces NF-kappa- B activity via RIPK2 and IKK-gamma. Confers responsiveness to intracellular bacterial lipopolysaccharides (LPS). Forms an intracellular sensing system along with ARHGEF2 for the detection of microbial effectors during cell invasion by pathogens. Required for RHOA and RIPK2 dependent NF-kappa-B signaling pathways activation upon S.flexneri cell invasion. Involved not only in sensing peptidoglycan (PGN)-derived muropeptides but also in the activation of NF-kappa-B by Shigella effector proteins IpgB2 and OspB. SUBUNIT: Homodimer. Self-associates. Binds to caspase-9 and RIPK2 by CARD-CARD interaction. Interacts with ARHGEF2. INTERACTION: Self; NbExp=2; IntAct=EBI-1051262, EBI-1051262; SUBCELLULAR LOCATION: Cytoplasm. Basolateral cell membrane. Note=Recruited to the basolateral membrane compartment in polarized epithelial cells. TISSUE SPECIFICITY: Highly expressed in adult heart, skeletal muscle, pancreas, spleen and ovary. Also detected in placenta, lung, liver, kidney, thymus, testis, small intestine and colon. SIMILARITY: Contains 1 CARD domain. SIMILARITY: Contains 9 LRR (leucine-rich) repeats. SIMILARITY: Contains 1 NACHT domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9Y239
Front
Top
Side
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0000166 nucleotide binding GO:0005515 protein binding GO:0005524 ATP binding GO:0008656 cysteine-type endopeptidase activator activity involved in apoptotic process GO:0042802 identical protein binding GO:0042803 protein homodimerization activity GO:0042834 peptidoglycan binding GO:0050700 CARD domain binding
Biological Process: GO:0000187 activation of MAPK activity GO:0002376 immune system process GO:0002606 positive regulation of dendritic cell antigen processing and presentation GO:0006915 apoptotic process GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process GO:0006952 defense response GO:0006954 inflammatory response GO:0007165 signal transduction GO:0007254 JNK cascade GO:0009595 detection of biotic stimulus GO:0010942 positive regulation of cell death GO:0016045 detection of bacterium GO:0032731 positive regulation of interleukin-1 beta production GO:0032755 positive regulation of interleukin-6 production GO:0032760 positive regulation of tumor necrosis factor production GO:0032874 positive regulation of stress-activated MAPK cascade GO:0035556 intracellular signal transduction GO:0042228 interleukin-8 biosynthetic process GO:0042742 defense response to bacterium GO:0042981 regulation of apoptotic process GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0045087 innate immune response GO:0046330 positive regulation of JNK cascade GO:0050830 defense response to Gram-positive bacterium GO:0051000 positive regulation of nitric-oxide synthase activity GO:0051092 positive regulation of NF-kappaB transcription factor activity GO:0051259 protein oligomerization GO:0070374 positive regulation of ERK1 and ERK2 cascade GO:0070423 nucleotide-binding oligomerization domain containing signaling pathway GO:0070498 interleukin-1-mediated signaling pathway GO:0071225 cellular response to muramyl dipeptide GO:1901224 positive regulation of NIK/NF-kappaB signaling GO:1904417 positive regulation of xenophagy
US Server
