ID:DC1I1_HUMAN DESCRIPTION: RecName: Full=Cytoplasmic dynein 1 intermediate chain 1; AltName: Full=Cytoplasmic dynein intermediate chain 1; AltName: Full=Dynein intermediate chain 1, cytosolic; Short=DH IC-1; FUNCTION: Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. The intermediate chains mediate the binding of dynein to dynactin via its 150 kDa component (p150- glued) DCNT1. May play a role in mediating the interaction of cytoplasmic dynein with membranous organelles and kinetochores. SUBUNIT: Homodimer (By similarity). The cytoplasmic dynein 1 complex consists of two catalytic heavy chains (HCs) and a number of non-catalytic subunits presented by intermediate chains (ICs), light intermediate chains (LICs) and light chains (LCs); the composition seems to vary in respect to the IC, LIC and LC composition. The heavy chain homodimer serves as a scaffold for the probable homodimeric assembly of the respective non-catalytic subunits. The ICs and LICs bind directly to the HC dimer and the LCs assemble on the IC dimer. Interacts with DYNC1H1. Interacts with DYNLT1 and DYNLT3. Interacts with DCNT1 (By similarity). SUBCELLULAR LOCATION: Cytoplasm (By similarity). Chromosome, centromere, kinetochore. Cytoplasm, cytoskeleton, spindle pole. SIMILARITY: Belongs to the dynein intermediate chain family. SIMILARITY: Contains 7 WD repeats.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on O14576
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0006888 ER to Golgi vesicle-mediated transport GO:0007018 microtubule-based movement GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II GO:0047496 vesicle transport along microtubule GO:2000582 positive regulation of ATP-dependent microtubule motor activity, plus-end-directed
AK091339 - Homo sapiens cDNA FLJ34020 fis, clone FCBBF2002904, highly similar to DYNEIN INTERMEDIATE CHAIN 1, CYTOSOLIC. BC032945 - Homo sapiens dynein, cytoplasmic 1, intermediate chain 1, mRNA (cDNA clone MGC:33107 IMAGE:4801387), complete cds. AK313148 - Homo sapiens cDNA, FLJ93640, Homo sapiens dynein, cytoplasmic, intermediate polypeptide 1(DNCI1), mRNA. BC053542 - Homo sapiens dynein, cytoplasmic 1, intermediate chain 1, mRNA (cDNA clone MGC:61489 IMAGE:5727968), complete cds. BC037854 - Homo sapiens dynein, cytoplasmic 1, intermediate chain 1, mRNA (cDNA clone MGC:42314 IMAGE:4817657), complete cds. AF063228 - Homo sapiens cytoplasmic dynein intermediate chain 1 mRNA, complete cds. AK297427 - Homo sapiens cDNA FLJ59721 complete cds, highly similar to Cytoplasmic dynein 1 intermediate chain 1. BC022540 - Homo sapiens dynein, cytoplasmic 1, intermediate chain 1, mRNA (cDNA clone MGC:26796 IMAGE:4793415), complete cds. AF123074 - Homo sapiens cytoplasmic dynein intermediate chain 1 mRNA, complete cds. BC012504 - Homo sapiens dynein, cytoplasmic 1, intermediate chain 1, mRNA (cDNA clone IMAGE:4708704), with apparent retained intron. AK309419 - Homo sapiens cDNA, FLJ99460. CU691514 - Synthetic construct Homo sapiens gateway clone IMAGE:100017437 5' read DYNC1I1 mRNA. CU689576 - Synthetic construct Homo sapiens gateway clone IMAGE:100020398 5' read DYNC1I1 mRNA. CU692684 - Synthetic construct Homo sapiens gateway clone IMAGE:100017436 5' read DYNC1I1 mRNA. AB463590 - Synthetic construct DNA, clone: pF1KB8374, Homo sapiens DYNC1I1 gene for dynein, cytoplasmic 1, intermediate chain 1, without stop codon, in Flexi system. KJ905729 - Synthetic construct Homo sapiens clone ccsbBroadEn_15399 DYNC1I1 gene, encodes complete protein. KJ896716 - Synthetic construct Homo sapiens clone ccsbBroadEn_06110 DYNC1I1 gene, encodes complete protein. KJ896717 - Synthetic construct Homo sapiens clone ccsbBroadEn_06111 DYNC1I1 gene, encodes complete protein. JD401509 - Sequence 382533 from Patent EP1572962. JD458062 - Sequence 439086 from Patent EP1572962. JD189571 - Sequence 170595 from Patent EP1572962. JD289306 - Sequence 270330 from Patent EP1572962. JD200341 - Sequence 181365 from Patent EP1572962. JD373055 - Sequence 354079 from Patent EP1572962. JD458555 - Sequence 439579 from Patent EP1572962. LF207031 - JP 2014500723-A/14534: Polycomb-Associated Non-Coding RNAs. MA442608 - JP 2018138019-A/14534: Polycomb-Associated Non-Coding RNAs. LF360350 - JP 2014500723-A/167853: Polycomb-Associated Non-Coding RNAs. MA595927 - JP 2018138019-A/167853: Polycomb-Associated Non-Coding RNAs. JD124481 - Sequence 105505 from Patent EP1572962. JD123395 - Sequence 104419 from Patent EP1572962. JD116435 - Sequence 97459 from Patent EP1572962. JD514353 - Sequence 495377 from Patent EP1572962. JD503190 - Sequence 484214 from Patent EP1572962. JD283725 - Sequence 264749 from Patent EP1572962. JD232471 - Sequence 213495 from Patent EP1572962. JD506125 - Sequence 487149 from Patent EP1572962. JD266183 - Sequence 247207 from Patent EP1572962. JD285614 - Sequence 266638 from Patent EP1572962.
Biochemical and Signaling Pathways
KEGG - Kyoto Encyclopedia of Genes and Genomes hsa04962 - Vasopressin-regulated water reabsorption
Reactome (by CSHL, EBI, and GO)
Protein O14576 (Reactome details) participates in the following event(s):
R-HSA-141409 Mad1 binds kinetochore R-HSA-375302 Kinetochore capture of astral microtubules R-HSA-5666129 CDC42:GTP recruits DIAPH2-2 to kinetochores R-HSA-5666169 Kinetochore capture of astral microtubules is positively regulated by CDC42:GTP:p-S196-DIAPH2-2 R-HSA-6809003 ERGIC-to-Golgi vesicles bind dynein:dynactin R-HSA-6809006 Vesicle is tethered through binding GOLGA2:GORASP1, GOLGB1 and the COG complex R-HSA-141431 MAD2 associates with the Mad1 kinetochore complex R-HSA-141439 Release of activated MAD2 from kinetochores R-HSA-2467811 Separation of sister chromatids R-HSA-2467809 ESPL1 (Separase) cleaves centromeric cohesin R-HSA-5666160 AURKB phosphorylates DIAPH2-2 at kinetochores R-HSA-8849350 RAB6:GTP displaces PAFAH1B1 from dynein:dynactin complex R-HSA-141422 MAD2 converted to an inhibitory state via interaction with Mad1 R-HSA-1638821 PP2A-B56 dephosphorylates centromeric cohesin R-HSA-1638803 Phosphorylation of cohesin by PLK1 at centromeres R-HSA-2468287 CDK1 phosphorylates CDCA5 (Sororin) at centromeres R-HSA-141444 Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-68877 Mitotic Prometaphase R-HSA-5663220 RHO GTPases Activate Formins R-HSA-2132295 MHC class II antigen presentation R-HSA-6807878 COPI-mediated anterograde transport R-HSA-6811436 COPI-independent Golgi-to-ER retrograde traffic R-HSA-2500257 Resolution of Sister Chromatid Cohesion R-HSA-2467813 Separation of Sister Chromatids R-HSA-141424 Amplification of signal from the kinetochores R-HSA-68886 M Phase R-HSA-195258 RHO GTPase Effectors R-HSA-1280218 Adaptive Immune System R-HSA-199977 ER to Golgi Anterograde Transport R-HSA-8856688 Golgi-to-ER retrograde transport R-HSA-68882 Mitotic Anaphase R-HSA-69618 Mitotic Spindle Checkpoint R-HSA-69278 Cell Cycle (Mitotic) R-HSA-194315 Signaling by Rho GTPases R-HSA-168256 Immune System R-HSA-199991 Membrane Trafficking R-HSA-948021 Transport to the Golgi and subsequent modification R-HSA-6811442 Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-2555396 Mitotic Metaphase and Anaphase R-HSA-69620 Cell Cycle Checkpoints R-HSA-1640170 Cell Cycle R-HSA-162582 Signal Transduction R-HSA-5653656 Vesicle-mediated transport R-HSA-446203 Asparagine N-linked glycosylation R-HSA-597592 Post-translational protein modification R-HSA-392499 Metabolism of proteins
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