Human Gene PTCD1 (ENST00000292478.9) from GENCODE V44
Description: Homo sapiens pentatricopeptide repeat domain 1 (PTCD1), mRNA; nuclear gene for mitochondrial product. (from RefSeq NM_015545) RefSeq Summary (NM_015545): This gene encodes a mitochondrial protein that binds leucine tRNAs and other mitochondrial RNAs and plays a role in the regulation of translation. Increased expression of this gene results in decreased mitochondrial leucine tRNA levels. Naturally occurring read-through transcription exists between upstream ATP5J2 (ATP synthase, H+ transporting, mitochondrial Fo complex, subunit F2) and this gene. [provided by RefSeq, Aug 2015]. Gencode Transcript: ENST00000292478.9 Gencode Gene: ENSG00000106246.18 Transcript (Including UTRs) Position: hg38 chr7:99,416,739-99,438,798 Size: 22,060 Total Exon Count: 8 Strand: - Coding Region Position: hg38 chr7:99,419,967-99,435,242 Size: 15,276 Coding Exon Count: 7
ID:PTCD1_HUMAN DESCRIPTION: RecName: Full=Pentatricopeptide repeat-containing protein 1, mitochondrial; FUNCTION: Mitochondrial protein implicated in negative regulation of leucine tRNA levels, as well as negative regulation of mitochondria-encoded proteins and COX activity. Affects also the 3' processing of mitochondrial tRNAs. SUBUNIT: Associates with mitochondrial leucine tRNAs. Interacts with ELAC2. SUBCELLULAR LOCATION: Mitochondrion. Mitochondrion matrix (By similarity). TISSUE SPECIFICITY: Abundant in testes, skeletal muscle and heart. SIMILARITY: Belongs to the PTCD1 family. SIMILARITY: Contains 9 PPR (pentatricopeptide) repeats. SEQUENCE CAUTION: Sequence=BAA31607.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on O75127
Front
Top
Side
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
