Human Gene COPS6 (ENST00000303904.8) from GENCODE V44
Description: Homo sapiens COP9 signalosome subunit 6 (COPS6), mRNA. (from RefSeq NM_006833) RefSeq Summary (NM_006833): The protein encoded by this gene is one of the eight subunits of COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. The structure and function of COP9 signalosome is similar to that of the 19S regulatory particle of 26S proteasome. COP9 signalosome has been shown to interact with SCF-type E3 ubiquitin ligases and act as a positive regulator of E3 ubiquitin ligases. This protein belongs to translation initiation factor 3 (eIF3) superfamily. It is involved in the regulation of cell cycle and likely to be a cellular cofactor for HIV-1 accessory gene product Vpr. [provided by RefSeq, Jul 2008]. Gencode Transcript: ENST00000303904.8 Gencode Gene: ENSG00000168090.10 Transcript (Including UTRs) Position: hg38 chr7:100,088,969-100,092,187 Size: 3,219 Total Exon Count: 10 Strand: + Coding Region Position: hg38 chr7:100,088,991-100,091,789 Size: 2,799 Coding Exon Count: 10
ID:CSN6_HUMAN DESCRIPTION: RecName: Full=COP9 signalosome complex subunit 6; Short=SGN6; Short=Signalosome subunit 6; AltName: Full=JAB1-containing signalosome subunit 6; AltName: Full=MOV34 homolog; AltName: Full=Vpr-interacting protein; Short=hVIP; FUNCTION: Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Has some glucocorticoid receptor- responsive activity. Stabilizes RFWD2/COP1 through reducing RFWD2 auto-ubiquitination and decelerating RFWD2 turnover rate, hence regulates the ubiquitination of RFWD2 targets. SUBUNIT: Component of the CSN complex, composed of COPS1/GPS1, COPS2, COPS3, COPS4, COPS5, COP6, COPS7 (COPS7A or COPS7B) and COPS8. In the complex, it probably interacts directly with COPS2, COPS4, COPS5 and COPS7 (COPS7A or COPS7B). Interacts with the translation initiation factor EIF3S6. Interacts weakly with RBX1. Interacts with the HIV-1 protein Vpr. Directly interacts with RFWD2 and 14-3-3 protein sigma/SFN. INTERACTION: Q9BX70:BTBD2; NbExp=2; IntAct=EBI-486838, EBI-710091; Q8NHY2:RFWD2; NbExp=3; IntAct=EBI-486838, EBI-1176214; P31947:SFN; NbExp=7; IntAct=EBI-486838, EBI-476295; SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Note=The interaction with HIV-1 Vpr protein possibly leads its translocation to a perinuclear region. TISSUE SPECIFICITY: Widely expressed. MISCELLANEOUS: Although strongly related to metalloprotease proteins, it lacks the JAMM motif that probably constitutes the catalytic center. Its function as protease is therefore unsure. SIMILARITY: Belongs to the peptidase M67A family. CSN6 subfamily. SIMILARITY: Contains 1 MPN (JAB/Mov34) domain. SEQUENCE CAUTION: Sequence=AAD03469.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF01398 - JAB1/Mov34/MPN/PAD-1 ubiquitin protease PF13012 - Maintenance of mitochondrial structure and function
ModBase Predicted Comparative 3D Structure on Q7L5N1
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
