Human Gene KCND2 (ENST00000331113.9) from GENCODE V44
Description: Homo sapiens potassium voltage-gated channel subfamily D member 2 (KCND2), mRNA. (from RefSeq NM_012281) RefSeq Summary (NM_012281): Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shal-related subfamily, members of which form voltage-activated A-type potassium ion channels and are prominent in the repolarization phase of the action potential. This member mediates a rapidly inactivating, A-type outward potassium current which is not under the control of the N terminus as it is in Shaker channels. [provided by RefSeq, Jul 2008]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Gencode Transcript: ENST00000331113.9 Gencode Gene: ENSG00000184408.10 Transcript (Including UTRs) Position: hg38 chr7:120,273,175-120,750,337 Size: 477,163 Total Exon Count: 6 Strand: + Coding Region Position: hg38 chr7:120,274,633-120,747,858 Size: 473,226 Coding Exon Count: 6
ID:KCND2_HUMAN DESCRIPTION: RecName: Full=Potassium voltage-gated channel subfamily D member 2; AltName: Full=Voltage-gated potassium channel subunit Kv4.2; FUNCTION: Pore-forming (alpha) subunit of voltage-gated rapidly inactivating A-type potassium channels. May contribute to I(To) current in heart and I(Sa) current in neurons. Channel properties are modulated by interactions with other alpha subunits and with regulatory subunits. SUBUNIT: Homotetramer or heterotetramer with KCND1 and/or KCND3. Interacts with DPP6, DLG4 and NCS1/FREQ (By similarity). Interacts with DLG1. Associates with the regulatory subunits KCNIP1, KCNIP2, KCNIP3 and KCNIP4. Probably part of a complex consisting of KCNIP1, KCNIP2 isoform 3 and KCND2. The KCND2-KCNIP2 channel complex contains four KCND2 and four KCNIP2 subunits. Interacts with FLNA, FLNC and DPP10. INTERACTION: Q9NZI2:KCNIP1; NbExp=4; IntAct=EBI-1646745, EBI-2120635; Q9NS61-3:KCNIP2; NbExp=3; IntAct=EBI-1646745, EBI-1053010; SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. Cell projection, dendrite. Note=Detected in dendrites in cultured hippocampal neurons. Association with KCNIP2 probably enhances cell surface expression. TISSUE SPECIFICITY: Highly expressed throughout the brain. Expression is very low or absent in other tissues. DOMAIN: The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position. PTM: Phosphorylated on serine and threonine residues (By similarity). SIMILARITY: Belongs to the potassium channel family. D (Shal) (TC 1.A.1.2) subfamily. Kv4.2/KCND2 sub-subfamily. SEQUENCE CAUTION: Sequence=BAA82996.2; Type=Erroneous initiation;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF11879 - Domain of unknown function (DUF3399) PF00520 - Ion transport protein PF02214 - BTB/POZ domain PF11601 - Shal-type voltage-gated potassium channels, N-terminal
ModBase Predicted Comparative 3D Structure on Q9NZV8
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
