Human Gene HYAL4 (ENST00000223026.9) from GENCODE V44
Description: Homo sapiens hyaluronidase 4 (HYAL4), mRNA. (from RefSeq NM_012269) RefSeq Summary (NM_012269): This gene encodes a protein which is similar in structure to hyaluronidases but lacks hyaluronidase activity. The encoded protein acts as a chondroitin-sulfate-specific endo-beta-N-acetylgalactosaminidase; that is, it exhibits hydrolytic activity toward chondroitin sulfate chains and degrades them into oligosaccharides. Proteoglycans are formed by the covalent linkage of chondroitin sulfate chains to protein. Proteoglycans are ubiquitous components of the extracellular matrix of connective tissues and are also found at the surface of many cell types where they participate in a variety of cellular processes such as cell proliferation, differentiation, migration, cell-cell recognition, extracellular matrix deposition, and tissue morphogenesis. The expression of this gene is highest in testes and placenta. [provided by RefSeq, Apr 2019]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data because no single transcript was available for the full length of the gene. The extent of this transcript is supported by transcript alignments. Gencode Transcript: ENST00000223026.9 Gencode Gene: ENSG00000106302.10 Transcript (Including UTRs) Position: hg38 chr7:123,845,169-123,877,481 Size: 32,313 Total Exon Count: 5 Strand: + Coding Region Position: hg38 chr7:123,868,274-123,877,155 Size: 8,882 Coding Exon Count: 3
ID:HYAL4_HUMAN DESCRIPTION: RecName: Full=Hyaluronidase-4; Short=Hyal-4; EC=3.2.1.35; AltName: Full=Chondroitin sulfate endo-beta-N-acetylgalactosaminidase; AltName: Full=Chondroitin sulfate hydrolase; Short=CSHY; AltName: Full=Hyaluronoglucosaminidase-4; FUNCTION: Endo-hyaluronidase that degrades hyaluronan to smaller oligosaccharide fragments. Has also chondroitin sulfate hydrolase activity, The best substrate being the galactosaminidic linkage in the sequence of a trisulfated tetrasaccharide. CATALYTIC ACTIVITY: Random hydrolysis of (1->4)-linkages between N-acetyl-beta-D-glucosamine and D-glucuronate residues in hyaluronate. BIOPHYSICOCHEMICAL PROPERTIES: pH dependence: Optimum pH is 4.5-5 (for chondroitin sulfate hydrolase activity); Temperature dependence: Optimum temperature is 37 degrees Celsius; SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein (Potential). TISSUE SPECIFICITY: Detected in placenta and skeletal muscle. SIMILARITY: Belongs to the glycosyl hydrolase 56 family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q2M3T9
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0005975 carbohydrate metabolic process GO:0006027 glycosaminoglycan catabolic process GO:0008152 metabolic process GO:0030207 chondroitin sulfate catabolic process
US Server
