Human Gene AHCYL2 (ENST00000446544.6) from GENCODE V44
Description: S-adenosyl-L-homocysteine + H(2)O = L- homocysteine + adenosine. (from UniProt Q96HN2)
RefSeq Summary (NM_001130720): The protein encoded by this gene acts as a homotetramer and may be involved in the conversion of S-adenosyl-L-homocysteine to L-homocysteine and adenosine. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2011].
Gencode Transcript: ENST00000446544.6
Gencode Gene: ENSG00000158467.17
Transcript (Including UTRs)
Position: hg38 chr7:129,225,050-129,430,211 Size: 205,162 Total Exon Count: 17 Strand: +
Coding Region
Position: hg38 chr7:129,225,077-129,427,045 Size: 201,969 Coding Exon Count: 17
Data last updated at UCSC: 2023-08-18 00:09:47
Sequence and Links to Tools and Databases
Comments and Description Text from UniProtKB
ID: SAHH3_HUMAN
DESCRIPTION: RecName: Full=Putative adenosylhomocysteinase 3; Short=AdoHcyase 3; EC=3.3.1.1; AltName: Full=S-adenosyl-L-homocysteine hydrolase 3; AltName: Full=S-adenosylhomocysteine hydrolase-like protein 2;
CATALYTIC ACTIVITY: S-adenosyl-L-homocysteine + H(2)O = L- homocysteine + adenosine.COFACTOR: Binds 1 NAD per subunit.PATHWAY: Amino-acid biosynthesis; L-homocysteine biosynthesis; L- homocysteine from S-adenosyl-L-homocysteine: step 1/1.SUBUNIT: Homotetramer (Probable).SIMILARITY: Belongs to the adenosylhomocysteinase family.SEQUENCE CAUTION: Sequence=BAA74851.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Primer design for this transcript
Comparative Toxicogenomics Database (CTD)
RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
Microarray Expression Data
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mRNA Secondary Structure of 3' and 5' UTRs
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Protein Domain and Structure Information
InterPro Domains: Graphical view of domain structure IPR000043 - Adenosylhomocysteinase
IPR015878 - Ado_hCys_hydrolase_NAD-bd
IPR020082 - S-Ado-L-homoCys_hydrolase_CS
Pfam Domains: PF05221 - S-adenosyl-L-homocysteine hydrolase
PF00670 - S-adenosyl-L-homocysteine hydrolase, NAD binding domain
Protein Data Bank (PDB) 3-D Structure
ModBase Predicted Comparative 3D Structure on Q96HN2
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Descriptions from all associated GenBank mRNAs
LF207063 - JP 2014500723-A/14566: Polycomb-Associated Non-Coding RNAs.MA442640 - JP 2018138019-A/14566: Polycomb-Associated Non-Coding RNAs.BC024325 - Homo sapiens S-adenosylhomocysteine hydrolase-like 2, mRNA (cDNA clone MGC:21525 IMAGE:3907552), complete cds.AB020635 - Homo sapiens KIAA0828 mRNA for KIAA0828 protein.BC008349 - Homo sapiens S-adenosylhomocysteine hydrolase-like 2, mRNA (cDNA clone MGC:15925 IMAGE:3536052), complete cds.AB384003 - Synthetic construct DNA, clone: pF1KSDA0828, Homo sapiens SAHH3 gene for adenosylhomocysteinase 3, complete cds, without stop codon, in Flexi system.KJ893363 - Synthetic construct Homo sapiens clone ccsbBroadEn_02757 AHCYL2 gene, encodes complete protein.AK130743 - Homo sapiens cDNA FLJ27233 fis, clone SYN06481, highly similar to Adenosylhomocysteinase (EC 3.3.1.1).JD158255 - Sequence 139279 from Patent EP1572962.JD541181 - Sequence 522205 from Patent EP1572962.JD206188 - Sequence 187212 from Patent EP1572962.AK129958 - Homo sapiens cDNA FLJ26448 fis, clone KDN02955.JD472150 - Sequence 453174 from Patent EP1572962.LF360954 - JP 2014500723-A/168457: Polycomb-Associated Non-Coding RNAs.MA596531 - JP 2018138019-A/168457: Polycomb-Associated Non-Coding RNAs.AK025372 - Homo sapiens cDNA: FLJ21719 fis, clone COLF0094.AK316073 - Homo sapiens cDNA, FLJ78972 complete cds, highly similar to Putative adenosylhomocysteinase 3 (EC 3.3.1.1).AK295851 - Homo sapiens cDNA FLJ59697 complete cds, highly similar to Putative adenosylhomocysteinase 3 (EC 3.3.1.1).LF360983 - JP 2014500723-A/168486: Polycomb-Associated Non-Coding RNAs.MA596560 - JP 2018138019-A/168486: Polycomb-Associated Non-Coding RNAs.LF360984 - JP 2014500723-A/168487: Polycomb-Associated Non-Coding RNAs.MA596561 - JP 2018138019-A/168487: Polycomb-Associated Non-Coding RNAs.AK172759 - Homo sapiens cDNA FLJ23920 fis, clone COL02027.JD491314 - Sequence 472338 from Patent EP1572962.JD313603 - Sequence 294627 from Patent EP1572962.JD243762 - Sequence 224786 from Patent EP1572962.JD209684 - Sequence 190708 from Patent EP1572962.JD209685 - Sequence 190709 from Patent EP1572962.JD476443 - Sequence 457467 from Patent EP1572962.JD297895 - Sequence 278919 from Patent EP1572962.LF360989 - JP 2014500723-A/168492: Polycomb-Associated Non-Coding RNAs.MA596566 - JP 2018138019-A/168492: Polycomb-Associated Non-Coding RNAs.JD315750 - Sequence 296774 from Patent EP1572962.JD099824 - Sequence 80848 from Patent EP1572962.JD363258 - Sequence 344282 from Patent EP1572962.JD048357 - Sequence 29381 from Patent EP1572962.JD340625 - Sequence 321649 from Patent EP1572962.JD296466 - Sequence 277490 from Patent EP1572962.JD337152 - Sequence 318176 from Patent EP1572962.JD320979 - Sequence 302003 from Patent EP1572962.JD368524 - Sequence 349548 from Patent EP1572962.JD378920 - Sequence 359944 from Patent EP1572962.JD262772 - Sequence 243796 from Patent EP1572962.LF360990 - JP 2014500723-A/168493: Polycomb-Associated Non-Coding RNAs.MA596567 - JP 2018138019-A/168493: Polycomb-Associated Non-Coding RNAs.JD323966 - Sequence 304990 from Patent EP1572962.JD562277 - Sequence 543301 from Patent EP1572962.JD434270 - Sequence 415294 from Patent EP1572962.JD154673 - Sequence 135697 from Patent EP1572962.JD433141 - Sequence 414165 from Patent EP1572962.JD559839 - Sequence 540863 from Patent EP1572962.JD103407 - Sequence 84431 from Patent EP1572962.JD297578 - Sequence 278602 from Patent EP1572962.JD333584 - Sequence 314608 from Patent EP1572962.JD515104 - Sequence 496128 from Patent EP1572962.JD528813 - Sequence 509837 from Patent EP1572962.LF360991 - JP 2014500723-A/168494: Polycomb-Associated Non-Coding RNAs.MA596568 - JP 2018138019-A/168494: Polycomb-Associated Non-Coding RNAs.JD122579 - Sequence 103603 from Patent EP1572962.JD254976 - Sequence 236000 from Patent EP1572962.JD155342 - Sequence 136366 from Patent EP1572962.JD290466 - Sequence 271490 from Patent EP1572962.JD289568 - Sequence 270592 from Patent EP1572962.JD546063 - Sequence 527087 from Patent EP1572962.JD509440 - Sequence 490464 from Patent EP1572962.JD287700 - Sequence 268724 from Patent EP1572962.JD248293 - Sequence 229317 from Patent EP1572962.JD567003 - Sequence 548027 from Patent EP1572962.JD565939 - Sequence 546963 from Patent EP1572962.JD248489 - Sequence 229513 from Patent EP1572962.JD369782 - Sequence 350806 from Patent EP1572962.JD559288 - Sequence 540312 from Patent EP1572962.JD428852 - Sequence 409876 from Patent EP1572962.JD484549 - Sequence 465573 from Patent EP1572962.JD358901 - Sequence 339925 from Patent EP1572962.JD316354 - Sequence 297378 from Patent EP1572962.JD394248 - Sequence 375272 from Patent EP1572962.JD548596 - Sequence 529620 from Patent EP1572962.JD496024 - Sequence 477048 from Patent EP1572962.JD072947 - Sequence 53971 from Patent EP1572962.JD164104 - Sequence 145128 from Patent EP1572962.JD134324 - Sequence 115348 from Patent EP1572962.JD189213 - Sequence 170237 from Patent EP1572962.JD433070 - Sequence 414094 from Patent EP1572962.JD047319 - Sequence 28343 from Patent EP1572962.
Biochemical and Signaling Pathways
KEGG - Kyoto Encyclopedia of Genes and Genomes hsa00270 - Cysteine and methionine metabolismhsa00450 - Selenoamino acid metabolismhsa01100 - Metabolic pathways
Other Names for This Gene
Alternate Gene Symbols: B4DIZ5, ENST00000446544.1, ENST00000446544.2, ENST00000446544.3, ENST00000446544.4, ENST00000446544.5, KIAA0828, NM_001393389, O94917, Q96HN2, SAHH3_HUMAN, uc003vot.1, uc003vot.2, uc003vot.3, uc003vot.4UCSC ID: ENST00000446544.6RefSeq Accession: NM_001130720
Protein: Q96HN2
(aka SAHH3_HUMAN or SAH3_HUMAN)
CCDS: CCDS5812.1 , CCDS47706.1
Methods, Credits, and Use Restrictions
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for details on how this gene model was made and data restrictions if any.