Human Gene AGPAT5 (ENST00000285518.11) from GENCODE V44
Description: Homo sapiens 1-acylglycerol-3-phosphate O-acyltransferase 5 (AGPAT5), mRNA. (from RefSeq NM_018361) RefSeq Summary (NM_018361): This gene encodes a member of the 1-acylglycerol-3-phosphate O-acyltransferase family. This integral membrane protein converts lysophosphatidic acid to phosphatidic acid, the second step in de novo phospholipid biosynthesis. A pseudogene of this gene is present on the Y chromosome. [provided by RefSeq, Aug 2014]. Gencode Transcript: ENST00000285518.11 Gencode Gene: ENSG00000155189.12 Transcript (Including UTRs) Position: hg38 chr8:6,708,642-6,761,503 Size: 52,862 Total Exon Count: 8 Strand: + Coding Region Position: hg38 chr8:6,708,669-6,757,388 Size: 48,720 Coding Exon Count: 8
ID:PLCE_HUMAN DESCRIPTION: RecName: Full=1-acyl-sn-glycerol-3-phosphate acyltransferase epsilon; EC=2.3.1.51; AltName: Full=1-acylglycerol-3-phosphate O-acyltransferase 5; Short=1-AGP acyltransferase 5; Short=1-AGPAT 5; AltName: Full=Lysophosphatidic acid acyltransferase epsilon; Short=LPAAT-epsilon; FUNCTION: Converts lysophosphatidic acid (LPA) into phosphatidic acid by incorporating an acyl moiety at the sn-2 position of the glycerol backbone (By similarity). CATALYTIC ACTIVITY: Acyl-CoA + 1-acyl-sn-glycerol 3-phosphate = CoA + 1,2-diacyl-sn-glycerol 3-phosphate. PATHWAY: Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 2/3. SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein (Potential). DOMAIN: The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate (By similarity). SIMILARITY: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family. CAUTION: It is uncertain whether Met-1 or Met-12 is the initiator. SEQUENCE CAUTION: Sequence=BAA92069.1; Type=Erroneous initiation;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9NUQ2
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
