Human Gene DEFB103A (ENST00000314357.4) from GENCODE V44
Description: Homo sapiens defensin beta 103A (DEFB103A), mRNA. (from RefSeq NM_001081551) RefSeq Summary (NM_001081551): Defensins form a family of microbicidal and cytotoxic peptides made by neutrophils. Members of the defensin family are highly similar in protein sequence. This gene encodes defensin, beta 103, an antibiotic peptide which is induced by bacteria and interferon gamma, and which displays antimicrobial activity against S. aureus, S. pyogenes, P. aeruginosa, E. coli, and C. albicans. [provided by RefSeq, Oct 2014]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Gencode Transcript: ENST00000314357.4 Gencode Gene: ENSG00000176797.4 Transcript (Including UTRs) Position: hg38 chr8:7,881,392-7,882,663 Size: 1,272 Total Exon Count: 2 Strand: + Coding Region Position: hg38 chr8:7,881,422-7,882,568 Size: 1,147 Coding Exon Count: 2
ID:D103A_HUMAN DESCRIPTION: RecName: Full=Beta-defensin 103; AltName: Full=Beta-defensin 3; Short=BD-3; Short=DEFB-3; Short=HBD3; Short=hBD-3; AltName: Full=Defensin, beta 103; AltName: Full=Defensin-like protein; Flags: Precursor; FUNCTION: Exhibits antimicrobial activity against Gram-positive bacteria S.aureus and S.pyogenes, Gram-negative bacteria P.aeruginosa and E.coli and the yeast C.albicans. Kills multiresistant S.aureus and vancomycin-resistant E.faecium. No significant hemolytic activity was observed. SUBCELLULAR LOCATION: Secreted. TISSUE SPECIFICITY: Highly expressed in skin and tonsils, and to a lesser extent in trachea, uterus, kidney, thymus, adenoid, pharynx and tongue. Low expression in salivary gland, bone marrow, colon, stomach, polyp and larynx. No expression in small intestine. INDUCTION: By bacterial infection and by IFNG/IFN-gamma. MASS SPECTROMETRY: Mass=5154.59; Method=Electrospray; Range=23-67; Source=PubMed:11085990; SIMILARITY: Belongs to the beta-defensin family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P81534
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
