Human Gene CNOT7 (ENST00000361272.9) from GENCODE V44
Description: Homo sapiens CCR4-NOT transcription complex subunit 7 (CNOT7), transcript variant 1, mRNA. (from RefSeq NM_013354) RefSeq Summary (NM_013354): The protein encoded by this gene binds to an anti-proliferative protein, B-cell translocation protein 1, which negatively regulates cell proliferation. Binding of the two proteins, which is driven by phosphorylation of the anti-proliferative protein, causes signaling events in cell division that lead to changes in cell proliferation associated with cell-cell contact. The encoded protein downregulates the innate immune response and therefore provides a therapeutic target for enhancing its antimicrobial activity against foreign agents. Alternative splicing of this gene results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 1 and X. [provided by RefSeq, Apr 2016]. Gencode Transcript: ENST00000361272.9 Gencode Gene: ENSG00000198791.12 Transcript (Including UTRs) Position: hg38 chr8:17,224,966-17,246,857 Size: 21,892 Total Exon Count: 7 Strand: - Coding Region Position: hg38 chr8:17,230,720-17,245,152 Size: 14,433 Coding Exon Count: 6
ID:CNOT7_HUMAN DESCRIPTION: RecName: Full=CCR4-NOT transcription complex subunit 7; AltName: Full=BTG1-binding factor 1; AltName: Full=CCR4-associated factor 1; Short=CAF-1; FUNCTION: Ubiquitous transcription factor required for a diverse set of processes. It is a component of the CCR4 complex involved in the control of gene expression (By similarity). SUBUNIT: Interacts with TOB1. Interacts with NANOS2 (By similarity). SUBCELLULAR LOCATION: Nucleus. Cytoplasm, P-body (By similarity). Note=NANOS2 promotes its localization to P-body (By similarity). SIMILARITY: Belongs to the CAF1 family. SEQUENCE CAUTION: Sequence=AAF01500.1; Type=Frameshift; Positions=4;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9UIV1
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0000175 3'-5'-exoribonuclease activity GO:0001191 transcriptional repressor activity, RNA polymerase II transcription factor binding GO:0003676 nucleic acid binding GO:0003700 transcription factor activity, sequence-specific DNA binding GO:0003723 RNA binding GO:0004518 nuclease activity GO:0004527 exonuclease activity GO:0004532 exoribonuclease activity GO:0004535 poly(A)-specific ribonuclease activity GO:0004871 signal transducer activity GO:0005515 protein binding GO:0008134 transcription factor binding GO:0016787 hydrolase activity GO:0046872 metal ion binding
Biological Process: GO:0000122 negative regulation of transcription from RNA polymerase II promoter GO:0000289 nuclear-transcribed mRNA poly(A) tail shortening GO:0000290 deadenylation-dependent decapping of nuclear-transcribed mRNA GO:0005975 carbohydrate metabolic process GO:0006351 transcription, DNA-templated GO:0006355 regulation of transcription, DNA-templated GO:0006417 regulation of translation GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0007165 signal transduction GO:0008284 positive regulation of cell proliferation GO:0008285 negative regulation of cell proliferation GO:0010629 negative regulation of gene expression GO:0031047 gene silencing by RNA GO:0033962 cytoplasmic mRNA processing body assembly GO:0035195 gene silencing by miRNA GO:0042509 regulation of tyrosine phosphorylation of STAT protein GO:0043928 exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay GO:0045070 positive regulation of viral genome replication GO:0045892 negative regulation of transcription, DNA-templated GO:0045944 positive regulation of transcription from RNA polymerase II promoter GO:0051607 defense response to virus GO:0060213 positive regulation of nuclear-transcribed mRNA poly(A) tail shortening GO:0060339 negative regulation of type I interferon-mediated signaling pathway GO:0061014 positive regulation of mRNA catabolic process GO:0090305 nucleic acid phosphodiester bond hydrolysis GO:0090503 RNA phosphodiester bond hydrolysis, exonucleolytic GO:1900153 positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
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