Human Gene INSL4 (ENST00000239316.4) from GENCODE V44
Description: Homo sapiens insulin like 4 (INSL4), mRNA. (from RefSeq NM_002195) RefSeq Summary (NM_002195): INSL4 encodes the insulin-like 4 protein, a member of the insulin superfamily. INSL4 encodes a precursor that undergoes post-translational cleavage to produce 3 polypeptide chains, A-C, that form tertiary structures composed of either all three chains, or just the A and B chains. Expression of INSL4 products occurs within the early placental cytotrophoblast and syncytiotrophoblast. [provided by RefSeq, Jul 2008]. Gencode Transcript: ENST00000239316.4 Gencode Gene: ENSG00000120211.4 Transcript (Including UTRs) Position: hg38 chr9:5,231,419-5,235,304 Size: 3,886 Total Exon Count: 2 Strand: + Coding Region Position: hg38 chr9:5,231,524-5,233,877 Size: 2,354 Coding Exon Count: 2
ID:INSL4_HUMAN DESCRIPTION: RecName: Full=Early placenta insulin-like peptide; Short=EPIL; AltName: Full=Insulin-like peptide 4; AltName: Full=Placentin; Contains: RecName: Full=Early placenta insulin-like peptide B chain; Contains: RecName: Full=Early placenta insulin-like peptide A chain; Flags: Precursor; FUNCTION: May play an important role in trophoblast development and in the regulation of bone formation. SUBCELLULAR LOCATION: Secreted (By similarity). TISSUE SPECIFICITY: Expressed in placenta, uterus and in fetal perichondrium. Expression levels were increased in both early placentas and molar pregnancies and were reduced in choriocarcinoma cells. DEVELOPMENTAL STAGE: Highly expressed in the early placenta. Expression of epil peptides in the villous cytotrophoblast is different from that displayed by the syncytiotrophoblast. In fetal tissues it was identified in the perichondrium of all four limbs, vertebrae, and ribs. It was abundant in interbone ligaments. SIMILARITY: Belongs to the insulin family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q14641
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.