Human Gene TRPM3 (ENST00000361823.9) from GENCODE V44
Description: Homo sapiens transient receptor potential cation channel subfamily M member 3 (TRPM3), transcript variant 7, mRNA. (from RefSeq NM_206948) RefSeq Summary (NM_206948): The product of this gene belongs to the family of transient receptor potential (TRP) channels. TRP channels are cation-selective channels important for cellular calcium signaling and homeostasis. The protein encoded by this gene mediates calcium entry, and this entry is potentiated by calcium store depletion. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]. Gencode Transcript: ENST00000361823.9 Gencode Gene: ENSG00000083067.26 Transcript (Including UTRs) Position: hg38 chr9:70,783,860-70,869,029 Size: 85,170 Total Exon Count: 7 Strand: - Coding Region Position: hg38 chr9:70,784,101-70,862,910 Size: 78,810 Coding Exon Count: 5
ID:TRPM3_HUMAN DESCRIPTION: RecName: Full=Transient receptor potential cation channel subfamily M member 3; AltName: Full=Long transient receptor potential channel 3; Short=LTrpC-3; Short=LTrpC3; AltName: Full=Melastatin-2; Short=MLSN2; FUNCTION: Calcium channel mediating constitutive calcium ion entry. Its activity is increased by reduction in extracellular osmolarity, by store depletion and muscarinic receptor activation. SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein. TISSUE SPECIFICITY: Expressed primarily in the kidney and, at lower levels, in brain, testis, ovary, pancreas and spinal cord. Expression in the brain and kidney was determined at protein level. In the kidney, expressed predominantly in the collecting tubular epithelium in the medulla, medullary rays, and periglomerular regions; in the brain, highest levels are found in the cerebellum, choroid plexus, the locus coeruleus, the posterior thalamus and the substantia nigra. Down-regulated in renal tumors compared to normal kidney. SIMILARITY: Belongs to the transient receptor (TC 1.A.4) family. LTrpC subfamily. TRPM3 sub-subfamily. SEQUENCE CAUTION: Sequence=CAB66480.2; Type=Miscellaneous discrepancy; Note=Cloning artifact in C-terminus; Sequence=CAM13096.1; Type=Erroneous gene model prediction; Sequence=CAM13169.1; Type=Erroneous gene model prediction; Sequence=CAM15782.1; Type=Erroneous gene model prediction; Sequence=CAM17596.1; Type=Erroneous gene model prediction; Sequence=CAM22746.1; Type=Erroneous gene model prediction;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9HCF6
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0006811 ion transport GO:0006812 cation transport GO:0006816 calcium ion transport GO:0016048 detection of temperature stimulus GO:0034220 ion transmembrane transport GO:0050951 sensory perception of temperature stimulus GO:0051262 protein tetramerization GO:0055085 transmembrane transport GO:0070588 calcium ion transmembrane transport
US Server
