Human Gene CTSV (ENST00000259470.6) from GENCODE V44
Description: Homo sapiens cathepsin V (CTSV), transcript variant 1, mRNA. (from RefSeq NM_001333) RefSeq Summary (NM_001333): The protein encoded by this gene, a member of the peptidase C1 family, is a lysosomal cysteine proteinase that may play an important role in corneal physiology. This gene is expressed in colorectal and breast carcinomas but not in normal colon, mammary gland, or peritumoral tissues, suggesting a possible role for this gene in tumor processes. Alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jan 2011]. Gencode Transcript: ENST00000259470.6 Gencode Gene: ENSG00000136943.12 Transcript (Including UTRs) Position: hg38 chr9:97,029,677-97,039,142 Size: 9,466 Total Exon Count: 8 Strand: - Coding Region Position: hg38 chr9:97,032,949-97,038,043 Size: 5,095 Coding Exon Count: 7
ID:CATL2_HUMAN DESCRIPTION: RecName: Full=Cathepsin L2; EC=3.4.22.43; AltName: Full=Cathepsin U; AltName: Full=Cathepsin V; Flags: Precursor; FUNCTION: Cysteine protease. May have an important role in corneal physiology. CATALYTIC ACTIVITY: The recombinant enzyme hydrolyzes proteins (serum albumin, collagen) and synthetic substrates (Z-Phe-Arg- NHMec > Z-Leu-Arg-NHMec > Z-Val-Arg-NHMec). SUBCELLULAR LOCATION: Lysosome (Potential). TISSUE SPECIFICITY: Predominantly expressed in the thymus and testis. Also expressed in corneal epithelium, and to a lesser extent in conjunctival epithelium and skin. SIMILARITY: Belongs to the peptidase C1 family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on O60911
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0006508 proteolysis GO:0007154 cell communication GO:0007283 spermatogenesis GO:0008584 male gonad development GO:0009267 cellular response to starvation GO:0009749 response to glucose GO:0010259 multicellular organism aging GO:0010839 negative regulation of keratinocyte proliferation GO:0014070 response to organic cyclic compound GO:0016485 protein processing GO:0016540 protein autoprocessing GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II GO:0021675 nerve development GO:0022617 extracellular matrix disassembly GO:0031069 hair follicle morphogenesis GO:0034698 response to gonadotropin GO:0045616 regulation of keratinocyte differentiation GO:0046697 decidualization GO:0048102 autophagic cell death GO:0051384 response to glucocorticoid GO:0051603 proteolysis involved in cellular protein catabolic process GO:0060008 Sertoli cell differentiation GO:1990834 response to odorant GO:2000249 regulation of actin cytoskeleton reorganization
US Server
