Human Gene CLIC3 (ENST00000494426.2) from GENCODE V44
Description: Homo sapiens chloride intracellular channel 3 (CLIC3), mRNA. (from RefSeq NM_004669) RefSeq Summary (NM_004669): Chloride channels are a diverse group of proteins that regulate fundamental cellular processes including stabilization of cell membrane potential, transepithelial transport, maintenance of intracellular pH, and regulation of cell volume. Chloride intracellular channel 3 is a member of the p64 family and is predominantly localized in the nucleus and stimulates chloride ion channel activity. In addition, this protein may participate in cellular growth control, based on its association with ERK7, a member of the MAP kinase family. [provided by RefSeq, Jul 2008]. Gencode Transcript: ENST00000494426.2 Gencode Gene: ENSG00000169583.13 Transcript (Including UTRs) Position: hg38 chr9:136,994,608-136,996,568 Size: 1,961 Total Exon Count: 6 Strand: - Coding Region Position: hg38 chr9:136,994,681-136,996,543 Size: 1,863 Coding Exon Count: 6
ID:CLIC3_HUMAN DESCRIPTION: RecName: Full=Chloride intracellular channel protein 3; FUNCTION: Can insert into membranes and form chloride ion channels. May participate in cellular growth control. SUBUNIT: Associated with the C-terminal of ERK7. SUBCELLULAR LOCATION: Nucleus. Membrane; Single-pass membrane protein. Cytoplasm. Note=Predominantly nuclear. Some protein was found in the cytoplasm. Exists both as soluble cytoplasmic protein and as membrane protein with probably a single transmembrane domain (By similarity). TISSUE SPECIFICITY: Detected in placenta (at protein level). Widely expressed. High expression is found in placenta followed by lung and heart. Low expression in skeletal muscle, kidney and pancreas. DOMAIN: Members of this family may change from a globular, soluble state to a state where the N-terminal domain is inserted into the membrane and functions as chloride channel. A conformation change of the N-terminal domain is thought to expose hydrophobic surfaces that trigger membrane insertion (By similarity). SIMILARITY: Belongs to the chloride channel CLIC family. SIMILARITY: Contains 1 GST C-terminal domain. SIMILARITY: Contains 1 GST N-terminal domain. SEQUENCE CAUTION: Sequence=AAD16450.1; Type=Frameshift; Positions=28;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on O95833
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0005244 voltage-gated ion channel activity GO:0005254 chloride channel activity GO:0005515 protein binding GO:0004364 glutathione transferase activity
Biological Process: GO:0006811 ion transport GO:0006821 chloride transport GO:0007165 signal transduction GO:0034220 ion transmembrane transport GO:0034765 regulation of ion transmembrane transport GO:1902476 chloride transmembrane transport GO:0006749 glutathione metabolic process
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