Human Gene SLC35A2 (ENST00000247138.11) from GENCODE V44
Description: Homo sapiens solute carrier family 35 member A2 (SLC35A2), transcript variant 1, mRNA. (from RefSeq NM_005660) RefSeq Summary (NM_005660): This gene encodes a member of the nucleotide-sugar transporter family. The encoded protein is a multi-pass membrane protein. It transports UDP-galactose from the cytosol into Golgi vesicles, where it serves as a glycosyl donor for the generation of glycans. Mutations in this gene cause congenital disorder of glycosylation type IIm (CDG2M). Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Oct 2014]. Gencode Transcript: ENST00000247138.11 Gencode Gene: ENSG00000102100.16 Transcript (Including UTRs) Position: hg38 chrX:48,903,183-48,911,646 Size: 8,464 Total Exon Count: 5 Strand: - Coding Region Position: hg38 chrX:48,903,438-48,911,636 Size: 8,199 Coding Exon Count: 5
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P78381
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0006012 galactose metabolic process GO:0008643 carbohydrate transport GO:0072334 UDP-galactose transmembrane transport GO:0090481 pyrimidine nucleotide-sugar transmembrane transport
D88146 - Homo sapiens UGT2 mRNA for UDP-galactose transporter 2, complete cds. JD337932 - Sequence 318956 from Patent EP1572962. JD416825 - Sequence 397849 from Patent EP1572962. JD121507 - Sequence 102531 from Patent EP1572962. JD182807 - Sequence 163831 from Patent EP1572962. JD159472 - Sequence 140496 from Patent EP1572962. JD477453 - Sequence 458477 from Patent EP1572962. D84454 - Homo sapiens mRNA for UDP-galactose translocator, complete cds. AK225508 - Homo sapiens mRNA for Splice isoform UGT1 of P78381 variant, clone: KAT02227. BC035747 - Homo sapiens solute carrier family 35 (UDP-galactose transporter), member A2, mRNA (cDNA clone MGC:46152 IMAGE:5749525), complete cds. AK090730 - Homo sapiens cDNA FLJ33411 fis, clone BRACE2019467, moderately similar to UDP-GALACTOSE TRANSLOCATOR. AX746592 - Sequence 117 from Patent EP1308459. AK290284 - Homo sapiens cDNA FLJ75119 complete cds, highly similar to Homo sapiens solute carrier family 35 (UDP-galactose transporter), member A2, transcript variant 2, mRNA. AK293415 - Homo sapiens cDNA FLJ59470 complete cds, highly similar to UDP-galactose translocator. AK293419 - Homo sapiens cDNA FLJ53300 complete cds, highly similar to UDP-galactose translocator. AK292816 - Homo sapiens cDNA FLJ77206 complete cds, highly similar to Human mRNA for UDP-galactose translocator. AK298484 - Homo sapiens cDNA FLJ59372 complete cds, highly similar to UDP-galactose translocator. KJ892355 - Synthetic construct Homo sapiens clone ccsbBroadEn_01749 SLC35A2 gene, encodes complete protein. CR450287 - Homo sapiens full open reading frame cDNA clone RZPDo834A121D for gene SLC35A2, solute carrier family 35 (UDP-galactose transporter), member A2; complete cds; without stopcodon. AK299748 - Homo sapiens cDNA FLJ59970 complete cds, highly similar to UDP-galactose translocator.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein P78381 (Reactome details) participates in the following event(s):
R-HSA-735702 SLC35A2 exchanges UDP-Gal, UDP-GalNAc for UMP R-HSA-727802 Metabolism of sugars R-HSA-425397 Transport of vitamins, nucleosides, and related molecules R-HSA-425407 SLC-mediated transmembrane transport R-HSA-382551 Transport of small molecules