ID:BEX3_HUMAN DESCRIPTION: RecName: Full=Protein BEX3; AltName: Full=Brain-expressed X-linked protein 3; AltName: Full=Nerve growth factor receptor-associated protein 1; AltName: Full=Ovarian granulosa cell 13.0 kDa protein HGR74; AltName: Full=p75NTR-associated cell death executor; FUNCTION: May be a signaling adapter molecule involved in p75NTR- mediated apoptosis induced by NGF. Plays a role in zinc-triggered neuronal death (By similarity). May play an important role in the pathogenesis of neurogenetic diseases. SUBUNIT: Self-associates. Interacts with 14-3-3 epsilon (YWHAE). Interacts with DIABLO/SMAC (By similarity). Binds to the DEATH domain of p75NTR/NGFR. INTERACTION: Q92574:TSC1; NbExp=5; IntAct=EBI-741753, EBI-1047085; SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Note=Shuttles between the cytoplasm and the nucleus. Associates with replicating mitochondria (By similarity). TISSUE SPECIFICITY: Found in ovarian granulosa cells, testis, prostate and seminal vesicle tissue. High levels also detected in liver. DOMAIN: The nuclear export signal is required for export from the nucleus and the interactions with itself and p75NTR/NGFR (By similarity). PTM: Ubiquitinated. Degraded by the proteasome (By similarity). MISCELLANEOUS: Binds transition metals (By similarity). SIMILARITY: Belongs to the BEX family. SEQUENCE CAUTION: Sequence=CAI41523.1; Type=Erroneous initiation;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q00994
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0005123 death receptor binding GO:0005163 nerve growth factor receptor binding GO:0005515 protein binding GO:0008656 cysteine-type endopeptidase activator activity involved in apoptotic process GO:0042802 identical protein binding GO:0046872 metal ion binding
Biological Process: GO:0006915 apoptotic process GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process GO:0007275 multicellular organism development GO:0008625 extrinsic apoptotic signaling pathway via death domain receptors GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process
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