Human Gene SRPK3 (ENST00000370101.8) from GENCODE V44
Description: Homo sapiens SRSF protein kinase 3 (SRPK3), transcript variant 1, mRNA. (from RefSeq NM_014370) RefSeq Summary (NM_014370): This gene encodes a protein kinase similar to a protein kinase which is specific for the SR (serine/arginine-rich domain) family of splicing factors. A highly similar protein has been shown to play a role in muscle development in mice. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2009]. Gencode Transcript: ENST00000370101.8 Gencode Gene: ENSG00000184343.11 Transcript (Including UTRs) Position: hg38 chrX:153,781,041-153,785,730 Size: 4,690 Total Exon Count: 15 Strand: + Coding Region Position: hg38 chrX:153,781,087-153,785,520 Size: 4,434 Coding Exon Count: 15
ID:SRPK3_HUMAN DESCRIPTION: RecName: Full=SRSF protein kinase 3; EC=2.7.11.1; AltName: Full=Muscle-specific serine kinase 1; Short=MSSK-1; AltName: Full=Serine/arginine-rich protein-specific kinase 3; Short=SR-protein-specific kinase 3; AltName: Full=Serine/threonine-protein kinase 23; FUNCTION: Serine/arginine-rich protein-specific kinase which specifically phosphorylates its substrates at serine residues located in regions rich in arginine/serine dipeptides, known as RS domains. Phosphorylates the SR splicing factor SRSF1 and the lamin-B receptor (LBR) in vitro. Required for normal muscle development (By similarity). CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein. TISSUE SPECIFICITY: Exclusively expressed in skeletal and heart muscle. SIMILARITY: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. SIMILARITY: Contains 1 protein kinase domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9UPE1
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0000245 spliceosomal complex assembly GO:0006468 protein phosphorylation GO:0007275 multicellular organism development GO:0007517 muscle organ development GO:0007519 skeletal muscle tissue development GO:0016310 phosphorylation GO:0030154 cell differentiation GO:0035556 intracellular signal transduction GO:0050684 regulation of mRNA processing GO:0060537 muscle tissue development
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