Human Gene AURKAIP1 (ENST00000321751.9) from GENCODE V44
  Description: Homo sapiens aurora kinase A interacting protein 1 (AURKAIP1), transcript variant 3, mRNA. (from RefSeq NM_001127230)
Gencode Transcript: ENST00000321751.9
Gencode Gene: ENSG00000175756.14
Transcript (Including UTRs)
   Position: hg38 chr1:1,373,732-1,375,169 Size: 1,438 Total Exon Count: 4 Strand: -
Coding Region
   Position: hg38 chr1:1,373,801-1,374,756 Size: 956 Coding Exon Count: 3 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
PathwaysOther NamesMethods
Data last updated at UCSC: 2023-08-18 00:09:47

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr1:1,373,732-1,375,169)mRNA (may differ from genome)Protein (199 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGencodeGeneCards
HGNCHPRDLynxMalacardsMGIneXtProt
OMIMPubMedReactomeUniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: AKIP_HUMAN
DESCRIPTION: RecName: Full=Aurora kinase A-interacting protein; Short=AURKA-interacting protein;
FUNCTION: May act as a negative regulator of Aurora-A kinase, by down-regulation through proteasome-dependent degradation.
SUBUNIT: Interacts with Aurora-A.
INTERACTION: O14965:AURKA; NbExp=2; IntAct=EBI-448665, EBI-448680;
SUBCELLULAR LOCATION: Nucleus.
TISSUE SPECIFICITY: Ubiquitously expressed and especially highly expressed in heart, skeletal muscle and testis.
SEQUENCE CAUTION: Sequence=AAH22808.1; Type=Erroneous initiation;

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 168.81 RPKM in Testis
Total median expression: 2039.52 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -68.70129-0.533 Picture PostScript Text
3' UTR -14.8069-0.214 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR013177 - DUF1713_mit

Pfam Domains:
PF08213 - Mitochondrial domain of unknown function (DUF1713)

ModBase Predicted Comparative 3D Structure on Q9NWT8
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-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
MGIRGD    
Protein SequenceProtein Sequence    
AlignmentAlignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005515 protein binding

Biological Process:
GO:0006397 mRNA processing
GO:0045839 negative regulation of mitotic nuclear division
GO:0045862 positive regulation of proteolysis
GO:0070125 mitochondrial translational elongation
GO:0070126 mitochondrial translational termination

Cellular Component:
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0005840 ribosome
GO:0043231 intracellular membrane-bounded organelle


-  Descriptions from all associated GenBank mRNAs
  AK000615 - Homo sapiens cDNA FLJ20608 fis, clone KAT05987.
BC046345 - Homo sapiens aurora kinase A interacting protein 1, mRNA (cDNA clone IMAGE:4425691), partial cds.
BC022808 - Homo sapiens aurora kinase A interacting protein 1, mRNA (cDNA clone IMAGE:5018271), partial cds.
BC062333 - Homo sapiens aurora kinase A interacting protein 1, mRNA (cDNA clone MGC:71201 IMAGE:5931927), complete cds.
JD380604 - Sequence 361628 from Patent EP1572962.
HQ447642 - Synthetic construct Homo sapiens clone IMAGE:100070988; CCSB013750_04 aurora kinase A interacting protein 1 (AURKAIP1) gene, encodes complete protein.
KJ894112 - Synthetic construct Homo sapiens clone ccsbBroadEn_03506 AURKAIP1 gene, encodes complete protein.
JD021704 - Sequence 2728 from Patent EP1572962.
JD025894 - Sequence 6918 from Patent EP1572962.
JD034427 - Sequence 15451 from Patent EP1572962.
BC035595 - Homo sapiens aurora kinase A interacting protein 1, mRNA (cDNA clone IMAGE:4997811).
JD323284 - Sequence 304308 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q9NWT8 (Reactome details) participates in the following event(s):

R-HSA-5368279 MTIF3 binds 28S ribosomal subunit
R-HSA-5419273 Hydrolysis of GTP and dissociation of 28S and 39S subunits
R-HSA-5389849 28S subunit:MTIF3 binds MTIF2:GTP, mRNA, and formylMet-tRNA
R-HSA-5389839 39S subunit binds 28S subunit:mRNA:fMet-tRNA
R-HSA-5389848 TUFM:GTP:aminoacyl-tRNA binds 55S ribosome:mRNA:fMet-tRNA
R-HSA-5389857 Peptide transfer from P-site to A-site (peptide bond formation)
R-HSA-5389842 TUFM hydrolyzes GTP and TUFM:GDP dissociates from 55S ribosome
R-HSA-5419261 55S ribosome with peptidyl-tRNA in A site binds GFM1:GTP
R-HSA-5419281 MRRF binds 55S ribosome:mRNA:tRNA
R-HSA-5419279 Translocation of peptidyl-tRNA from A-site to P-site (and translocation of 55S ribosome by 3 bases along mRNA)
R-HSA-5419264 MTRF1L (MTRF1a) or ICT1 binds stop codon in 55S ribosome:mRNA:peptidyl-tRNA
R-HSA-5419277 GFM2:GTP binds 55S ribosome:mRNA:tRNA:MRRF releasing mRNA and tRNA
R-HSA-5368286 Mitochondrial translation initiation
R-HSA-5419276 Mitochondrial translation termination
R-HSA-5368287 Mitochondrial translation
R-HSA-5389840 Mitochondrial translation elongation
R-HSA-72766 Translation
R-HSA-392499 Metabolism of proteins

-  Other Names for This Gene
  Alternate Gene Symbols: AIP, AKIP, AKIP_HUMAN, ENST00000321751.1, ENST00000321751.2, ENST00000321751.3, ENST00000321751.4, ENST00000321751.5, ENST00000321751.6, ENST00000321751.7, ENST00000321751.8, NM_001127230, Q5TA36, Q8TBD3, Q9NWT8, uc009vkb.1, uc009vkb.2
UCSC ID: ENST00000321751.9
RefSeq Accession: NM_001127230
Protein: Q9NWT8 (aka AKIP_HUMAN)
CCDS: CCDS25.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.