Human Gene IQCC (ENST00000537469.2) from GENCODE V44
  Description: Homo sapiens IQ motif containing C (IQCC), transcript variant 1, mRNA. (from RefSeq NM_001160042)
Gencode Transcript: ENST00000537469.2
Gencode Gene: ENSG00000160051.12
Transcript (Including UTRs)
   Position: hg38 chr1:32,205,671-32,208,682 Size: 3,012 Total Exon Count: 5 Strand: +
Coding Region
   Position: hg38 chr1:32,205,682-32,208,082 Size: 2,401 Coding Exon Count: 5 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesmRNA DescriptionsOther Names
Methods
Data last updated at UCSC: 2023-08-18 00:09:47

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr1:32,205,671-32,208,682)mRNA (may differ from genome)Protein (546 aa)
Gene SorterGenome BrowserOther Species FASTATable SchemaAlphaFoldBioGPS
EnsemblEntrez GeneExonPrimerGencodeGeneCardsHGNC
HPRDLynxMGIneXtProtPubMedUniProtKB
BioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: IQCC_HUMAN
DESCRIPTION: RecName: Full=IQ domain-containing protein C;
SIMILARITY: Contains 1 IQ domain.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 14.58 RPKM in Testis
Total median expression: 131.50 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
3' UTR -225.70600-0.376 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR000048 - IQ_motif_EF-hand-BS

ModBase Predicted Comparative 3D Structure on Q4KMZ1
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
MGIRGD    
Protein SequenceProtein Sequence    
AlignmentAlignment    

-  Descriptions from all associated GenBank mRNAs
  AK223272 - Homo sapiens mRNA for IQ motif containing C variant, clone: SYN01264.
AK307853 - Homo sapiens cDNA, FLJ97801.
AK299235 - Homo sapiens cDNA FLJ60335 complete cds, highly similar to Homo sapiens IQ motif containing C (IQCC), mRNA.
AK001409 - Homo sapiens cDNA FLJ10547 fis, clone NT2RP2001907.
BC098250 - Homo sapiens IQ motif containing C, mRNA (cDNA clone IMAGE:40024455), complete cds.
BC098260 - Homo sapiens IQ motif containing C, mRNA (cDNA clone MGC:120342 IMAGE:40024457), complete cds.
BC098317 - Homo sapiens IQ motif containing C, mRNA (cDNA clone MGC:120343 IMAGE:40024460), complete cds.
BC098366 - Homo sapiens IQ motif containing C, mRNA (cDNA clone MGC:120344 IMAGE:40024462), complete cds.
KJ894244 - Synthetic construct Homo sapiens clone ccsbBroadEn_03638 IQCC gene, encodes complete protein.
KJ894245 - Synthetic construct Homo sapiens clone ccsbBroadEn_03639 IQCC gene, encodes complete protein.
DQ574530 - Homo sapiens piRNA piR-42642, complete sequence.
BC029986 - Homo sapiens IQ motif containing C, mRNA (cDNA clone IMAGE:3924863).
JD263609 - Sequence 244633 from Patent EP1572962.
JD131987 - Sequence 113011 from Patent EP1572962.
JD086339 - Sequence 67363 from Patent EP1572962.
JD319727 - Sequence 300751 from Patent EP1572962.
JD276042 - Sequence 257066 from Patent EP1572962.
JD208891 - Sequence 189915 from Patent EP1572962.
JD566295 - Sequence 547319 from Patent EP1572962.
JD206548 - Sequence 187572 from Patent EP1572962.
JD185857 - Sequence 166881 from Patent EP1572962.
JD101893 - Sequence 82917 from Patent EP1572962.
JD481272 - Sequence 462296 from Patent EP1572962.
JD179366 - Sequence 160390 from Patent EP1572962.
JD208968 - Sequence 189992 from Patent EP1572962.
JD381148 - Sequence 362172 from Patent EP1572962.
JD045947 - Sequence 26971 from Patent EP1572962.
JD078968 - Sequence 59992 from Patent EP1572962.
JD078969 - Sequence 59993 from Patent EP1572962.
JD421863 - Sequence 402887 from Patent EP1572962.
JD105340 - Sequence 86364 from Patent EP1572962.
JD199093 - Sequence 180117 from Patent EP1572962.
JD199094 - Sequence 180118 from Patent EP1572962.
JD420217 - Sequence 401241 from Patent EP1572962.
JD264176 - Sequence 245200 from Patent EP1572962.
JD438887 - Sequence 419911 from Patent EP1572962.
JD094928 - Sequence 75952 from Patent EP1572962.
JD052920 - Sequence 33944 from Patent EP1572962.
JD188029 - Sequence 169053 from Patent EP1572962.
JD139892 - Sequence 120916 from Patent EP1572962.
JD351817 - Sequence 332841 from Patent EP1572962.
JD523743 - Sequence 504767 from Patent EP1572962.
JD201264 - Sequence 182288 from Patent EP1572962.
JD430146 - Sequence 411170 from Patent EP1572962.
JD557316 - Sequence 538340 from Patent EP1572962.
JD529131 - Sequence 510155 from Patent EP1572962.
JD388059 - Sequence 369083 from Patent EP1572962.
JD388060 - Sequence 369084 from Patent EP1572962.
JD449253 - Sequence 430277 from Patent EP1572962.
JD088721 - Sequence 69745 from Patent EP1572962.
JD155908 - Sequence 136932 from Patent EP1572962.
JD155907 - Sequence 136931 from Patent EP1572962.
JD366573 - Sequence 347597 from Patent EP1572962.
JD366574 - Sequence 347598 from Patent EP1572962.
JD366572 - Sequence 347596 from Patent EP1572962.
JD517752 - Sequence 498776 from Patent EP1572962.
JD117283 - Sequence 98307 from Patent EP1572962.
JD105971 - Sequence 86995 from Patent EP1572962.
JD105972 - Sequence 86996 from Patent EP1572962.
JD410985 - Sequence 392009 from Patent EP1572962.
JD214705 - Sequence 195729 from Patent EP1572962.
JD170804 - Sequence 151828 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000537469.1, IQCC_HUMAN, NM_001160042, Q4KMS3, Q4KMZ1, Q4KMZ5, Q53FL2, Q5TFJ8, Q9NVS3, uc009vua.1, uc009vua.2, uc009vua.3
UCSC ID: ENST00000537469.2
RefSeq Accession: NM_001160042
Protein: Q4KMZ1 (aka IQCC_HUMAN)
CCDS: CCDS53293.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.