Human Gene AKR1E2 (ENST00000345253.9) from GENCODE V44
Description: Homo sapiens aldo-keto reductase family 1 member E2 (AKR1E2), transcript variant 3, mRNA. (from RefSeq NM_001271025) RefSeq Summary (NM_001271025): The protein encoded by this gene is a member of the aldo-keto reductase superfamily. Members in this family are characterized by their structure (evolutionarily highly conserved TIM barrel) and function (NAD(P)H-dependent oxido-reduction of carbonyl groups). Transcripts of this gene have been reported in specimens of human testis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]. Gencode Transcript: ENST00000345253.9 Gencode Gene: ENSG00000165568.18 Transcript (Including UTRs) Position: hg38 chr10:4,826,296-4,847,745 Size: 21,450 Total Exon Count: 7 Strand: + Coding Region Position: hg38 chr10:4,826,325-4,847,530 Size: 21,206 Coding Exon Count: 7
ID:AKCL2_HUMAN DESCRIPTION: RecName: Full=1,5-anhydro-D-fructose reductase; Short=AF reductase; EC=1.1.1.263; AltName: Full=Aldo-keto reductase family 1 member C-like protein 2; AltName: Full=Aldo-keto reductase family 1 member E2; AltName: Full=LoopADR; AltName: Full=Testis-specific protein; Short=hTSP; FUNCTION: Catalyzes the NADPH-dependent reduction of 1,5-anhydro- D-fructose (AF) to 1,5-anhydro-D-glucitol. Can also catalyze the reduction of various aldehydes and quinones (By similarity). Has low NADPH-dependent reductase activity towards 9,10- phenanthrenequinone (in vitro). CATALYTIC ACTIVITY: 1,5-anhydro-D-glucitol + NADP(+) = 1,5- anhydro-D-fructose + NADPH. BIOPHYSICOCHEMICAL PROPERTIES: Kinetic parameters: KM=6.1 uM for 9,10-phenanthrenequinone with NADPH as cofactor; Vmax=0.42 nmol/min/mg enzyme towards 9,10-phenanthrenequinone with NADPH as cofactor; SUBCELLULAR LOCATION: Cytoplasm (Potential). TISSUE SPECIFICITY: Testis-specific. SIMILARITY: Belongs to the aldo/keto reductase family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF00248 - Aldo/keto reductase family
ModBase Predicted Comparative 3D Structure on Q96JD6
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
