Human Gene CARS1 (ENST00000470221.6) from GENCODE V44
Description: CARS1 (from geneSymbol) RefSeq Summary (NM_001751): This gene encodes a class 1 aminoacyl-tRNA synthetase, cysteinyl-tRNA synthetase. Each of the twenty aminoacyl-tRNA synthetases catalyzes the aminoacylation of a specific tRNA or tRNA isoaccepting family with the cognate amino acid. This gene is one of several located near the imprinted gene domain on chromosome 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian and breast cancers. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Aug 2010]. Gencode Transcript: ENST00000470221.6 Gencode Gene: ENSG00000110619.18 Transcript (Including UTRs) Position: hg38 chr11:3,000,930-3,009,533 Size: 8,604 Total Exon Count: 5 Strand: -
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Mouse
Rat
Zebrafish
D. melanogaster
C. elegans
S. cerevisiae
No ortholog
No ortholog
No ortholog
No ortholog
No ortholog
No ortholog
Descriptions from all associated GenBank mRNAs
AK222614 - Homo sapiens mRNA for cysteine-tRNA ligase isoform a variant, clone: CAS12492. BX647906 - Homo sapiens mRNA; cDNA DKFZp686F1612 (from clone DKFZp686F1612). BC002880 - Homo sapiens cysteinyl-tRNA synthetase, mRNA (cDNA clone MGC:11246 IMAGE:3940167), complete cds. AB208814 - Homo sapiens mRNA for cysteine-tRNA ligase isoform b variant protein. AK296763 - Homo sapiens cDNA FLJ59563 complete cds, highly similar to Cysteinyl-tRNA synthetase (EC 6.1.1.16). AK096313 - Homo sapiens cDNA FLJ38994 fis, clone NT2RI2009259, highly similar to Cysteinyl-tRNA synthetase (EC 6.1.1.16). AK295371 - Homo sapiens cDNA FLJ59524 complete cds, highly similar to Cysteinyl-tRNA synthetase (EC 6.1.1.16). AK298514 - Homo sapiens cDNA FLJ54534 complete cds, highly similar to Homo sapiens cysteinyl-tRNA synthetase (CARS), transcript variant 3, mRNA. AK302644 - Homo sapiens cDNA FLJ54741 complete cds, highly similar to Homo sapiens cysteinyl-tRNA synthetase (CARS), transcript variant 3, mRNA. L06845 - Human cysteinyl-tRNA synthetase mRNA, partial cds. AF288206 - Homo sapiens cytoplasmic cysteinyl-tRNA synthetase mRNA, complete cds. AF288207 - Homo sapiens cysteinyl-tRNA synthetase mRNA, complete cds, alternatively spliced. KJ890825 - Synthetic construct Homo sapiens clone ccsbBroadEn_00219 CARS gene, encodes complete protein. BT009913 - Homo sapiens cysteinyl-tRNA synthetase mRNA, complete cds. DQ890773 - Synthetic construct clone IMAGE:100003403; FLH165837.01X; RZPDo839H05160D cysteinyl-tRNA synthetase (CARS) gene, encodes complete protein. AK308005 - Homo sapiens cDNA, FLJ97953. AK289432 - Homo sapiens cDNA FLJ75536 partial cds, highly similar to Homo sapiens cysteinyl-tRNA synthetase (CARS), transcript variant1, mRNA. AK125503 - Homo sapiens cDNA FLJ43514 fis, clone PERIC2005347. AK126135 - Homo sapiens cDNA FLJ44147 fis, clone THYMU2028041, highly similar to Homo sapiens cysteinyl-tRNA synthetase (CARS). JD257539 - Sequence 238563 from Patent EP1572962. JD550784 - Sequence 531808 from Patent EP1572962. JD171370 - Sequence 152394 from Patent EP1572962. JD049682 - Sequence 30706 from Patent EP1572962. JD307495 - Sequence 288519 from Patent EP1572962. JD037179 - Sequence 18203 from Patent EP1572962. JD346653 - Sequence 327677 from Patent EP1572962. JD312174 - Sequence 293198 from Patent EP1572962. JD312175 - Sequence 293199 from Patent EP1572962. JD425257 - Sequence 406281 from Patent EP1572962. JD321898 - Sequence 302922 from Patent EP1572962. JD095273 - Sequence 76297 from Patent EP1572962.
Biochemical and Signaling Pathways
KEGG - Kyoto Encyclopedia of Genes and Genomes hsa00970 - Aminoacyl-tRNA biosynthesis