Human Gene CARS1 (ENST00000470221.6) from GENCODE V44
  Description: CARS1 (from geneSymbol)
RefSeq Summary (NM_001751): This gene encodes a class 1 aminoacyl-tRNA synthetase, cysteinyl-tRNA synthetase. Each of the twenty aminoacyl-tRNA synthetases catalyzes the aminoacylation of a specific tRNA or tRNA isoaccepting family with the cognate amino acid. This gene is one of several located near the imprinted gene domain on chromosome 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian and breast cancers. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Aug 2010].
Gencode Transcript: ENST00000470221.6
Gencode Gene: ENSG00000110619.18
Transcript (Including UTRs)
   Position: hg38 chr11:3,000,930-3,009,533 Size: 8,604 Total Exon Count: 5 Strand: -


Page IndexSequence and LinksPrimersRNA-Seq ExpressionMicroarray ExpressionOther Species
mRNA DescriptionsPathwaysOther NamesMethods
Data last updated at UCSC: 2023-08-18 00:09:47

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr11:3,000,930-3,009,533)mRNA (may differ from genome)No protein
Gene SorterGenome BrowserOther Species FASTATable SchemaBioGPSEnsembl
ExonPrimerGencodeMalacardsPubMed

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 17.92 RPKM in Cells - Cultured fibroblasts
Total median expression: 418.98 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
      
      
      
      
      

-  Descriptions from all associated GenBank mRNAs
  AK222614 - Homo sapiens mRNA for cysteine-tRNA ligase isoform a variant, clone: CAS12492.
BX647906 - Homo sapiens mRNA; cDNA DKFZp686F1612 (from clone DKFZp686F1612).
BC002880 - Homo sapiens cysteinyl-tRNA synthetase, mRNA (cDNA clone MGC:11246 IMAGE:3940167), complete cds.
AB208814 - Homo sapiens mRNA for cysteine-tRNA ligase isoform b variant protein.
AK296763 - Homo sapiens cDNA FLJ59563 complete cds, highly similar to Cysteinyl-tRNA synthetase (EC 6.1.1.16).
AK096313 - Homo sapiens cDNA FLJ38994 fis, clone NT2RI2009259, highly similar to Cysteinyl-tRNA synthetase (EC 6.1.1.16).
AK295371 - Homo sapiens cDNA FLJ59524 complete cds, highly similar to Cysteinyl-tRNA synthetase (EC 6.1.1.16).
AK298514 - Homo sapiens cDNA FLJ54534 complete cds, highly similar to Homo sapiens cysteinyl-tRNA synthetase (CARS), transcript variant 3, mRNA.
AK302644 - Homo sapiens cDNA FLJ54741 complete cds, highly similar to Homo sapiens cysteinyl-tRNA synthetase (CARS), transcript variant 3, mRNA.
L06845 - Human cysteinyl-tRNA synthetase mRNA, partial cds.
AF288206 - Homo sapiens cytoplasmic cysteinyl-tRNA synthetase mRNA, complete cds.
AF288207 - Homo sapiens cysteinyl-tRNA synthetase mRNA, complete cds, alternatively spliced.
KJ890825 - Synthetic construct Homo sapiens clone ccsbBroadEn_00219 CARS gene, encodes complete protein.
BT009913 - Homo sapiens cysteinyl-tRNA synthetase mRNA, complete cds.
DQ890773 - Synthetic construct clone IMAGE:100003403; FLH165837.01X; RZPDo839H05160D cysteinyl-tRNA synthetase (CARS) gene, encodes complete protein.
AK308005 - Homo sapiens cDNA, FLJ97953.
AK289432 - Homo sapiens cDNA FLJ75536 partial cds, highly similar to Homo sapiens cysteinyl-tRNA synthetase (CARS), transcript variant1, mRNA.
AK125503 - Homo sapiens cDNA FLJ43514 fis, clone PERIC2005347.
AK126135 - Homo sapiens cDNA FLJ44147 fis, clone THYMU2028041, highly similar to Homo sapiens cysteinyl-tRNA synthetase (CARS).
JD257539 - Sequence 238563 from Patent EP1572962.
JD550784 - Sequence 531808 from Patent EP1572962.
JD171370 - Sequence 152394 from Patent EP1572962.
JD049682 - Sequence 30706 from Patent EP1572962.
JD307495 - Sequence 288519 from Patent EP1572962.
JD037179 - Sequence 18203 from Patent EP1572962.
JD346653 - Sequence 327677 from Patent EP1572962.
JD312174 - Sequence 293198 from Patent EP1572962.
JD312175 - Sequence 293199 from Patent EP1572962.
JD425257 - Sequence 406281 from Patent EP1572962.
JD321898 - Sequence 302922 from Patent EP1572962.
JD095273 - Sequence 76297 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
hsa00970 - Aminoacyl-tRNA biosynthesis

-  Other Names for This Gene
  Alternate Gene Symbols: AK126135, ENST00000470221.1, ENST00000470221.2, ENST00000470221.3, ENST00000470221.4, ENST00000470221.5, uc009ydu.1, uc009ydu.2, uc009ydu.3, uc009ydu.4
UCSC ID: ENST00000470221.6
RefSeq Accession: NM_001751

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.