Human Gene FBXO3 (ENST00000530013.5) from GENCODE V44
  Description: F-box protein 3 (from HGNC FBXO3)
RefSeq Summary (NM_012175): This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. Alternative splicing of this gene generates 2 transcript variants diverging at the 3' end. [provided by RefSeq, Jul 2008].
Gencode Transcript: ENST00000530013.5
Gencode Gene: ENSG00000110429.14
Transcript (Including UTRs)
   Position: hg38 chr11:33,740,956-33,774,525 Size: 33,570 Total Exon Count: 11 Strand: -


Page IndexSequence and LinksPrimersCTDRNA-Seq ExpressionMicroarray Expression
Other SpeciesmRNA DescriptionsOther NamesMethods
Data last updated at UCSC: 2023-08-18 00:09:47

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr11:33,740,956-33,774,525)mRNA (may differ from genome)No protein
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
EnsemblExonPrimerGencodeHGNCLynxMalacards
PubMed

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 8.92 RPKM in Brain - Cerebellar Hemisphere
Total median expression: 257.39 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
      
      
      
      
      

-  Descriptions from all associated GenBank mRNAs
  LF205803 - JP 2014500723-A/13306: Polycomb-Associated Non-Coding RNAs.
MA441380 - JP 2018138019-A/13306: Polycomb-Associated Non-Coding RNAs.
AB209039 - Homo sapiens mRNA for F-box only protein 3 isoform 1 variant protein.
BC046110 - Homo sapiens F-box protein 3, mRNA (cDNA clone MGC:57538 IMAGE:5549548), complete cds.
AK001943 - Homo sapiens cDNA FLJ11081 fis, clone PLACE1005187, weakly similar to APAG PROTEIN.
AL136625 - Homo sapiens mRNA; cDNA DKFZp564B092 (from clone DKFZp564B092).
BC039291 - Homo sapiens F-box protein 3, mRNA (cDNA clone IMAGE:5296662), complete cds.
AK123198 - Homo sapiens cDNA FLJ41204 fis, clone BRACE3000404.
JD503283 - Sequence 484307 from Patent EP1572962.
AL832826 - Homo sapiens mRNA; cDNA DKFZp667I1524 (from clone DKFZp667I1524).
AK300721 - Homo sapiens cDNA FLJ58692 complete cds, highly similar to F-box only protein 3.
JD534207 - Sequence 515231 from Patent EP1572962.
JD315899 - Sequence 296923 from Patent EP1572962.
LF348390 - JP 2014500723-A/155893: Polycomb-Associated Non-Coding RNAs.
MA583967 - JP 2018138019-A/155893: Polycomb-Associated Non-Coding RNAs.
AK316286 - Homo sapiens cDNA, FLJ79185 complete cds, highly similar to F-box only protein 3.
JD135352 - Sequence 116376 from Patent EP1572962.
LF348389 - JP 2014500723-A/155892: Polycomb-Associated Non-Coding RNAs.
MA583966 - JP 2018138019-A/155892: Polycomb-Associated Non-Coding RNAs.
JD467505 - Sequence 448529 from Patent EP1572962.
KJ893554 - Synthetic construct Homo sapiens clone ccsbBroadEn_02948 FBXO3 gene, encodes complete protein.
EU832324 - Synthetic construct Homo sapiens clone HAIB:100067353; DKFZo008E0827 F-box protein 3 protein (FBXO3) gene, encodes complete protein.
EU832409 - Synthetic construct Homo sapiens clone HAIB:100067438; DKFZo004E0828 F-box protein 3 protein (FBXO3) gene, encodes complete protein.
LF348388 - JP 2014500723-A/155891: Polycomb-Associated Non-Coding RNAs.
MA583965 - JP 2018138019-A/155891: Polycomb-Associated Non-Coding RNAs.
AK128454 - Homo sapiens cDNA FLJ46597 fis, clone THYMU3046360, highly similar to F-box only protein 3.
AF176702 - Homo sapiens F-box protein FBX3 mRNA, partial cds.
LF348381 - JP 2014500723-A/155884: Polycomb-Associated Non-Coding RNAs.
MA583958 - JP 2018138019-A/155884: Polycomb-Associated Non-Coding RNAs.
AK304866 - Homo sapiens cDNA FLJ59154 complete cds, highly similar to F-box only protein 3.
LF348380 - JP 2014500723-A/155883: Polycomb-Associated Non-Coding RNAs.
MA583957 - JP 2018138019-A/155883: Polycomb-Associated Non-Coding RNAs.
LF348379 - JP 2014500723-A/155882: Polycomb-Associated Non-Coding RNAs.
MA583956 - JP 2018138019-A/155882: Polycomb-Associated Non-Coding RNAs.
CU692298 - Synthetic construct Homo sapiens gateway clone IMAGE:100021494 5' read FBXO3 mRNA.
LF348378 - JP 2014500723-A/155881: Polycomb-Associated Non-Coding RNAs.
MA583955 - JP 2018138019-A/155881: Polycomb-Associated Non-Coding RNAs.
AF174595 - Homo sapiens F-box protein Fbx3 (FBX3) mRNA, partial cds.
LF348377 - JP 2014500723-A/155880: Polycomb-Associated Non-Coding RNAs.
MA583954 - JP 2018138019-A/155880: Polycomb-Associated Non-Coding RNAs.
LF212906 - JP 2014500723-A/20409: Polycomb-Associated Non-Coding RNAs.
MA448483 - JP 2018138019-A/20409: Polycomb-Associated Non-Coding RNAs.

-  Other Names for This Gene
  Alternate Gene Symbols: BC039291, ENST00000530013.1, ENST00000530013.2, ENST00000530013.3, ENST00000530013.4, uc009ykb.1, uc009ykb.2, uc009ykb.3, uc009ykb.4
UCSC ID: ENST00000530013.5
RefSeq Accession: NM_012175

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.