Human Gene HSPA8 (ENST00000534319.5) from GENCODE V44
Description: Belongs to the heat shock protein 70 family. (from UniProt A8K7Q2) RefSeq Summary (NM_006597): This gene encodes a member of the heat shock protein 70 family, which contains both heat-inducible and constitutively expressed members. This protein belongs to the latter group, which are also referred to as heat-shock cognate proteins. It functions as a chaperone, and binds to nascent polypeptides to facilitate correct folding. It also functions as an ATPase in the disassembly of clathrin-coated vesicles during transport of membrane components through the cell. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]. Gencode Transcript: ENST00000534319.5 Gencode Gene: ENSG00000109971.14 Transcript (Including UTRs) Position: hg38 chr11:123,057,498-123,060,386 Size: 2,889 Total Exon Count: 6 Strand: - Coding Region Position: hg38 chr11:123,057,734-123,059,884 Size: 2,151 Coding Exon Count: 5
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on A8K7Q2
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
