Human Gene TEP1 (ENST00000555008.5) from GENCODE V44
  Description: The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data. (from UniProt G3V2A4)
RefSeq Summary (NM_001319035): This gene product is a component of the ribonucleoprotein complex responsible for telomerase activity which catalyzes the addition of new telomeres on the chromosome ends. The telomerase-associated proteins are conserved from ciliates to humans. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016].
Gencode Transcript: ENST00000555008.5
Gencode Gene: ENSG00000129566.13
Transcript (Including UTRs)
   Position: hg38 chr14:20,367,631-20,391,745 Size: 24,115 Total Exon Count: 43 Strand: -
Coding Region
   Position: hg38 chr14:20,368,851-20,391,745 Size: 22,895 Coding Exon Count: 42 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesmRNA DescriptionsPathways
Other NamesMethods
Data last updated at UCSC: 2023-08-18 00:09:47

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr14:20,367,631-20,391,745)mRNA (may differ from genome)Protein (1904 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblExonPrimerGencodeGeneCards
HGNCLynxMalacardsMGIPubMedUniProtKB
Wikipedia

-  Comments and Description Text from UniProtKB
  ID: G3V2A4_HUMAN
DESCRIPTION: SubName: Full=Telomerase protein component 1;
CAUTION: The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 12.23 RPKM in Small Intestine - Terminal Ileum
Total median expression: 220.92 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
3' UTR -310.60982-0.316 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR025139 - DUF4062
IPR007111 - NACHT_NTPase
IPR015943 - WD40/YVTN_repeat-like_dom
IPR001680 - WD40_repeat
IPR019775 - WD40_repeat_CS
IPR017986 - WD40_repeat_dom

Pfam Domains:
PF13271 - Domain of unknown function (DUF4062)
PF00400 - WD domain, G-beta repeat

ModBase Predicted Comparative 3D Structure on G3V2A4
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
MGIRGD    
Protein SequenceProtein Sequence    
AlignmentAlignment    

-  Descriptions from all associated GenBank mRNAs
  BX640983 - Homo sapiens mRNA; cDNA DKFZp686A04252 (from clone DKFZp686A04252).
AB209669 - Homo sapiens mRNA for Telomerase protein component 1 variant protein.
U86136 - Human telomerase-associated protein TP-1 mRNA, complete cds.
JD542818 - Sequence 523842 from Patent EP1572962.
JD536185 - Sequence 517209 from Patent EP1572962.
JD538348 - Sequence 519372 from Patent EP1572962.
JD144662 - Sequence 125686 from Patent EP1572962.
JD112401 - Sequence 93425 from Patent EP1572962.
JD542817 - Sequence 523841 from Patent EP1572962.
JD542819 - Sequence 523843 from Patent EP1572962.
JD112402 - Sequence 93426 from Patent EP1572962.
JD542816 - Sequence 523840 from Patent EP1572962.
JD376047 - Sequence 357071 from Patent EP1572962.
JD497752 - Sequence 478776 from Patent EP1572962.
JD222900 - Sequence 203924 from Patent EP1572962.
JD112400 - Sequence 93424 from Patent EP1572962.
JD222899 - Sequence 203923 from Patent EP1572962.
JD089526 - Sequence 70550 from Patent EP1572962.
JD171826 - Sequence 152850 from Patent EP1572962.
JD288384 - Sequence 269408 from Patent EP1572962.
JD090946 - Sequence 71970 from Patent EP1572962.
JD261834 - Sequence 242858 from Patent EP1572962.
JD556755 - Sequence 537779 from Patent EP1572962.
JD310369 - Sequence 291393 from Patent EP1572962.
JD176069 - Sequence 157093 from Patent EP1572962.
BC143812 - Homo sapiens cDNA clone IMAGE:9052327.
BC126107 - Homo sapiens telomerase-associated protein 1, mRNA (cDNA clone MGC:161385 IMAGE:8991823), complete cds.
BC143815 - Homo sapiens cDNA clone IMAGE:9052330, containing frame-shift errors.
JD171813 - Sequence 152837 from Patent EP1572962.
AK303307 - Homo sapiens cDNA FLJ50327 complete cds, highly similar to Telomerase protein component 1.
JD026974 - Sequence 7998 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  BioCarta from NCI Cancer Genome Anatomy Project
h_eif4Pathway - Regulation of eIF4e and p70 S6 Kinase
h_ptenPathway - PTEN dependent cell cycle arrest and apoptosis
h_igf1mtorpathway - Skeletal muscle hypertrophy is regulated via AKT/mTOR pathway
h_metPathway - Signaling of Hepatocyte Growth Factor Receptor
h_ctcfPathway - CTCF: First Multivalent Nuclear Factor
h_mTORPathway - mTOR Signaling Pathway

-  Other Names for This Gene
  Alternate Gene Symbols: AB209669, ENST00000555008.1, ENST00000555008.2, ENST00000555008.3, ENST00000555008.4, G3V2A4, G3V2A4_HUMAN, uc010ahk.1, uc010ahk.2, uc010ahk.3, uc010ahk.4
UCSC ID: ENST00000555008.5
RefSeq Accession: NM_001319035
Protein: G3V2A4

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.