Human Gene ESR2 (ENST00000555483.5) from GENCODE V44
  Description: Homo sapiens estrogen receptor 2 (ESR2), transcript variant i, non-coding RNA. (from RefSeq NR_073497)
RefSeq Summary (NR_073497): This gene encodes a member of the family of estrogen receptors and superfamily of nuclear receptor transcription factors. The gene product contains an N-terminal DNA binding domain and C-terminal ligand binding domain and is localized to the nucleus, cytoplasm, and mitochondria. Upon binding to 17beta-estradiol or related ligands, the encoded protein forms homo- or hetero-dimers that interact with specific DNA sequences to activate transcription. Some isoforms dominantly inhibit the activity of other estrogen receptor family members. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been fully characterized. [provided by RefSeq, Jul 2008].
Gencode Transcript: ENST00000555483.5
Gencode Gene: ENSG00000140009.19
Transcript (Including UTRs)
   Position: hg38 chr14:64,233,029-64,282,842 Size: 49,814 Total Exon Count: 7 Strand: -


Page IndexSequence and LinksPrimersMalaCardsCTDRNA-Seq Expression
Microarray ExpressionOther SpeciesmRNA DescriptionsOther NamesMethods
Data last updated at UCSC: 2023-08-18 00:09:47

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr14:64,233,029-64,282,842)mRNA (may differ from genome)No protein
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
EnsemblEntrez GeneExonPrimerGencodeHGNCLynx
MalacardsOMIMPubMedWikipediaBioGrid CRISPR DB

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: ESR2
Diseases sorted by gene-association score: medullary thyroid carcinoma, familial* (202), de quervain disease (18), transsexualism (16), gender identity disorder (16), endometrial cancer (15), breast cancer (14), lobular neoplasia (13), endometriosis (12), progesterone resistance (12), testicular germ cell cancer (11), breast disease (11), progesterone-receptor positive breast cancer (11), endometriosis of ovary (11), serous cystadenocarcinoma (11), vaginitis (10), endometrial adenocarcinoma (8), dental fluorosis (8), leiomyoma (8), cystadenocarcinoma (8), ovarian clear cell adenocarcinoma (7), uterine carcinosarcoma (7), seminoma (7), idiopathic scoliosis (7), postmenopausal atrophic vaginitis (6), infertility (6), sporadic breast cancer (6), prostate adenocarcinoma (6), diffuse glomerulonephritis (6), primary pigmented nodular adrenocortical disease (5), ovarian serous cystadenocarcinoma (5), estrogen excess (5), testicular germ cell tumor (5), osteoporosis (5), cerebellopontine angle tumor (5), plexopathy (4), in situ pulmonary adenocarcinoma (4), parotid gland cancer (4), prostate cancer (3), colorectal cancer (3), cryptorchidism (2), intrahepatic cholestasis (2), ovarian cancer, somatic (2), lung cancer (2), female reproductive system disease (1), reproductive system disease (1), reproductive organ cancer (1), male reproductive organ cancer (1)
* = Manually curated disease association

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 2.54 RPKM in Testis
Total median expression: 16.56 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
      
      
      
      
      

-  Descriptions from all associated GenBank mRNAs
  AF060555 - Homo sapiens estrogen receptor beta 3 isoform mRNA, complete cds.
AB006589 - Homo sapiens mRNA for estrogen receptor beta cx, complete cds.
BC024181 - Homo sapiens estrogen receptor 2 (ER beta), mRNA (cDNA clone MGC:26496 IMAGE:4825937), complete cds.
AF051428 - Homo sapiens estrogen receptor beta2 splice variant mRNA, complete cds.
LC122965 - Homo sapiens ESR2 mRNA for human estrogen receptor beta splice variant, ERbeta2delta7, complete cds.
LC122966 - Homo sapiens ESR2 mRNA for human estrogen receptor beta splice variant, ERbeta4delta7, complete cds.
LC122967 - Homo sapiens ESR2 mRNA for human estrogen receptor beta splice variant, ERbeta6, complete cds.
LC122968 - Homo sapiens ESR2 mRNA for human estrogen receptor beta splice variant, ERbeta6delta7, complete cds.
AK292370 - Homo sapiens cDNA FLJ77184 complete cds, highly similar to Homo sapiens estrogen receptor beta2 splice variant mRNA.
AF061054 - Homo sapiens estrogen receptor beta 4 splice variant mRNA, partial cds.
DQ838582 - Homo sapiens estrogen receptor beta isoform 4 (ESR2) mRNA, complete cds.
AF061055 - Homo sapiens estrogen receptor beta 5 splice variant mRNA, partial cds.
DQ838583 - Homo sapiens estrogen receptor beta isoform 5 (ESR2) mRNA, complete cds.
AF124790 - Homo sapiens estrogen receptor beta2 splice variant mRNA, complete cds.
HQ692821 - Homo sapiens estrogen nuclear receptor beta variant b (NR3A2) mRNA, complete cds.
DQ777076 - Homo sapiens estrogen receptor beta 4 mRNA, complete cds.
LC122969 - Homo sapiens ESR2 mRNA for human estrogen receptor beta splice variant, ERbeta7, complete cds.
LC122970 - Homo sapiens ESR2 mRNA for human estrogen receptor beta splice variant, ERbeta7delta7, complete cds.
AB209620 - Homo sapiens mRNA for estrogen receptor 2 (ER beta) variant protein.
AY438022 - Homo sapiens estrogen receptor beta mRNA, partial sequence.
X99101 - H.sapiens mRNA for estrogen receptor.
AF074599 - Homo sapiens estrogen receptor beta isoform 5/6 mRNA, partial cds.
AB006590 - Homo sapiens mRNA for estrogen receptor beta, complete cds.
HQ692820 - Homo sapiens estrogen nuclear receptor beta variant a (NR3A2) mRNA, complete cds.
AF051427 - Homo sapiens estrogen receptor beta mRNA, complete cds.
KJ534833 - Homo sapiens clone ESR2_iso-A_fetal-F02 estrogen receptor 2 isoform A (ESR2) mRNA, partial cds, alternatively spliced.
DQ777077 - Homo sapiens estrogen receptor beta 5-like mRNA, complete sequence.
AF074598 - Homo sapiens estrogen receptor beta isoform 6 mRNA, partial cds.
LC122972 - Homo sapiens ESR2 mRNA for human estrogen receptor beta splice variant, ERbetaEx. 6L, complete cds.
KJ901413 - Synthetic construct Homo sapiens clone ccsbBroadEn_10807 ESR2 gene, encodes complete protein.
KR709495 - Synthetic construct Homo sapiens clone CCSBHm_00002792 ESR2 (ESR2) mRNA, encodes complete protein.
LC122971 - Homo sapiens ESR2 mRNA for human estrogen receptor beta splice variant, ERbetaEx. 4L, complete cds.
AF047463 - Homo sapiens estrogen receptor beta mRNA, partial cds.

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000555483.1, ENST00000555483.2, ENST00000555483.3, ENST00000555483.4, NR_073497, uc010aqb.1, uc010aqb.2
UCSC ID: ENST00000555483.5
RefSeq Accession: NR_073497

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.