Human Gene SLC8A3 (ENST00000494208.5) from GENCODE V44
Description: Homo sapiens solute carrier family 8 member A3 (SLC8A3), transcript variant h, non-coding RNA. (from RefSeq NR_104122) RefSeq Summary (NM_033262): This gene encodes a member of the sodium/calcium exchanger integral membrane protein family. Na+/Ca2+ exchange proteins are involved in maintaining Ca2+ homeostasis in a wide variety of cell types. The protein is regulated by intracellular calcium ions and is found in both the plasma membrane and intracellular organellar membranes, where exchange of Na+ for Ca2+ occurs in an electrogenic manner. Alternative splicing has been observed for this gene and multiple variants have been described. [provided by RefSeq, Aug 2013]. Gencode Transcript: ENST00000494208.5 Gencode Gene: ENSG00000100678.20 Transcript (Including UTRs) Position: hg38 chr14:70,044,217-70,189,070 Size: 144,854 Total Exon Count: 6 Strand: - Coding Region Position: hg38 chr14:70,052,036-70,168,422 Size: 116,387 Coding Exon Count: 2
ID:NAC3_HUMAN DESCRIPTION: RecName: Full=Sodium/calcium exchanger 3; AltName: Full=Na(+)/Ca(2+)-exchange protein 3; Flags: Precursor; FUNCTION: Rapidly transports Ca(2+) during excitation-contraction coupling. Ca(2+) is extruded from the cell during relaxation so as to prevent overloading of intracellular stores (By similarity). ENZYME REGULATION: By intracellular calcium ions (By similarity). SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein. TISSUE SPECIFICITY: Isoform 2 is expressed in brain and skeletal muscle. Isoform 3 is expressed in excitable cells of brain, retina and skeletal muscle. Isoform 4 is expressed in skeletal muscle. SIMILARITY: Belongs to the sodium/potassium/calcium exchanger family. SLC8 subfamily. SIMILARITY: Contains 2 Calx-beta domains.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P57103
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0005432 calcium:sodium antiporter activity GO:0005516 calmodulin binding GO:0015297 antiporter activity GO:0015368 calcium:cation antiporter activity GO:0046872 metal ion binding GO:0099580 ion antiporter activity involved in regulation of postsynaptic membrane potential
Biological Process: GO:0002244 hematopoietic progenitor cell differentiation GO:0006811 ion transport GO:0006814 sodium ion transport GO:0006816 calcium ion transport GO:0006851 mitochondrial calcium ion transport GO:0006874 cellular calcium ion homeostasis GO:0007154 cell communication GO:0007612 learning GO:0007613 memory GO:0014819 regulation of skeletal muscle contraction GO:0021537 telencephalon development GO:0030001 metal ion transport GO:0035725 sodium ion transmembrane transport GO:0042552 myelination GO:0048709 oligodendrocyte differentiation GO:0051560 mitochondrial calcium ion homeostasis GO:0055085 transmembrane transport GO:0060078 regulation of postsynaptic membrane potential GO:0060291 long-term synaptic potentiation GO:0060402 calcium ion transport into cytosol GO:0070588 calcium ion transmembrane transport GO:0071320 cellular response to cAMP GO:0071456 cellular response to hypoxia GO:0098703 calcium ion import across plasma membrane GO:1903779 regulation of cardiac conduction GO:1990034 calcium ion export from cell
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