Human Gene ANXA2 (ENST00000559559.5) from GENCODE V44
  Description: annexin A2 (from HGNC ANXA2)
RefSeq Summary (NM_004039): This gene encodes a member of the annexin family. Members of this calcium-dependent phospholipid-binding protein family play a role in the regulation of cellular growth and in signal transduction pathways. This protein functions as an autocrine factor which heightens osteoclast formation and bone resorption. This gene has three pseudogenes located on chromosomes 4, 9 and 10, respectively. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. Annexin A2 expression has been found to correlate with resistance to treatment against various cancer forms. [provided by RefSeq, Dec 2019].
Gencode Transcript: ENST00000559559.5
Gencode Gene: ENSG00000182718.18
Transcript (Including UTRs)
   Position: hg38 chr15:60,355,428-60,397,988 Size: 42,561 Total Exon Count: 7 Strand: -


Page IndexSequence and LinksPrimersMalaCardsCTDRNA-Seq Expression
Microarray ExpressionOther SpeciesmRNA DescriptionsOther NamesMethods
Data last updated at UCSC: 2023-08-18 00:09:47

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr15:60,355,428-60,397,988)mRNA (may differ from genome)No protein
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
EnsemblExonPrimerGencodeHGNCLynxMalacards
PubMedWikipedia

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: ANXA2
Diseases sorted by gene-association score: retinitis pigmentosa 36 (3), keloid formation (3), pancreatic cancer (3), leukemia, acute promyelocytic, somatic (3), deep angioma (2), hemophagocytic lymphohistiocytosis, familial, 3 (1), intramuscular hemangioma (1), papillary hidradenoma (1), endocervicitis (1), dysgerminoma of ovary (1)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 464.40 RPKM in Cells - Cultured fibroblasts
Total median expression: 4246.18 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
      
      
      
      
      

-  Descriptions from all associated GenBank mRNAs
  HH837116 - Sequence 43 from Patent EP2231168.
HH837117 - Sequence 44 from Patent EP2231168.
HH837118 - Sequence 45 from Patent EP2231168.
HI214757 - Sequence 43 from Patent EP2076526.
HI214758 - Sequence 44 from Patent EP2076526.
HI214759 - Sequence 45 from Patent EP2076526.
HV601559 - JP 2011500003-A/43: Novel siRNA Structures.
HV601560 - JP 2011500003-A/44: Novel siRNA Structures.
HV601561 - JP 2011500003-A/45: Novel siRNA Structures.
HV856632 - JP 2010507387-A/43: Novel siRNAs and Methods of Use Thereof.
HV856633 - JP 2010507387-A/44: Novel siRNAs and Methods of Use Thereof.
HV856634 - JP 2010507387-A/45: Novel siRNAs and Methods of Use Thereof.
HW165119 - JP 2013102767-A/43: Novel siRNA's and Use Thereof.
HW165120 - JP 2013102767-A/44: Novel siRNA's and Use Thereof.
HW165121 - JP 2013102767-A/45: Novel siRNA's and Use Thereof.
HW675627 - JP 2014210789-A/43: Novel siRNA Structures.
HW675628 - JP 2014210789-A/44: Novel siRNA Structures.
HW675629 - JP 2014210789-A/45: Novel siRNA Structures.
HW835315 - JP 2015051004-A/43: Novel siRNA's and Use Thereof.
HW835316 - JP 2015051004-A/44: Novel siRNA's and Use Thereof.
HW835317 - JP 2015051004-A/45: Novel siRNA's and Use Thereof.
JA482123 - Sequence 106 from Patent WO2011072091.
JA482124 - Sequence 107 from Patent WO2011072091.
JA482125 - Sequence 108 from Patent WO2011072091.
JA482126 - Sequence 109 from Patent WO2011072091.
JA538158 - Sequence 43 from Patent EP2371958.
JA538159 - Sequence 44 from Patent EP2371958.
JA538160 - Sequence 45 from Patent EP2371958.
JE980415 - Sequence 106 from Patent EP2862929.
JE980416 - Sequence 107 from Patent EP2862929.
JE980417 - Sequence 108 from Patent EP2862929.
JE980418 - Sequence 109 from Patent EP2862929.
LQ740455 - Sequence 9 from Patent WO2018083189.
AK309356 - Homo sapiens cDNA, FLJ99397.
BC052558 - Homo sapiens annexin A2, mRNA (cDNA clone MGC:59828 IMAGE:6247665), complete cds.
AK124427 - Homo sapiens cDNA FLJ42436 fis, clone BLADE2007033, highly similar to ANNEXIN II.
BC068065 - Homo sapiens annexin A2, mRNA (cDNA clone MGC:78564 IMAGE:6265952), complete cds.
BC009564 - Homo sapiens annexin A2, mRNA (cDNA clone MGC:10129 IMAGE:3901641), complete cds.
BC021114 - Homo sapiens annexin A2, mRNA (cDNA clone MGC:31902 IMAGE:5092810), complete cds.
BC052567 - Homo sapiens annexin A2, mRNA (cDNA clone MGC:59829 IMAGE:6483607), complete cds.
BC001388 - Homo sapiens annexin A2, mRNA (cDNA clone MGC:2257 IMAGE:3051155), complete cds.
BC013843 - Homo sapiens annexin A2, mRNA (cDNA clone IMAGE:3918525).
BX640598 - Homo sapiens mRNA; cDNA DKFZp686P03159 (from clone DKFZp686P03159).
BC066955 - Homo sapiens annexin A2, mRNA (cDNA clone IMAGE:4826161).
LF213759 - JP 2014500723-A/21262: Polycomb-Associated Non-Coding RNAs.
MA449336 - JP 2018138019-A/21262: Polycomb-Associated Non-Coding RNAs.
AK092006 - Homo sapiens cDNA FLJ34687 fis, clone MESAN2000620, highly similar to Annexin A2.
AX747305 - Sequence 830 from Patent EP1308459.
D00017 - Homo sapiens mRNA for lipocortin II, complete cds.
AK297923 - Homo sapiens cDNA FLJ59138 complete cds, highly similar to Annexin A2.
BC016774 - Homo sapiens annexin A2, mRNA (cDNA clone MGC:23717 IMAGE:4096060), complete cds.
BC015834 - Homo sapiens annexin A2, mRNA (cDNA clone MGC:27157 IMAGE:4094952), complete cds.
BC093056 - Homo sapiens annexin A2, mRNA (cDNA clone MGC:111139 IMAGE:30403089), complete cds.
BC023990 - Homo sapiens annexin A2, mRNA (cDNA clone MGC:24294 IMAGE:3961419), complete cds.
FJ224302 - Homo sapiens epididymis secretory protein Li 270 (HEL-S-270) mRNA, complete cds.
AK222542 - Homo sapiens mRNA, annexin A2 isoform 1 variant, clone: adSU00201.
KJ896429 - Synthetic construct Homo sapiens clone ccsbBroadEn_05823 ANXA2 gene, encodes complete protein.
KJ896430 - Synthetic construct Homo sapiens clone ccsbBroadEn_05824 ANXA2 gene, encodes complete protein.
KJ896431 - Synthetic construct Homo sapiens clone ccsbBroadEn_05825 ANXA2 gene, encodes complete protein.
GQ891295 - Homo sapiens clone HEL-S-18a epididymis secretory sperm binding protein mRNA, complete cds.
BT007432 - Homo sapiens annexin A2 mRNA, complete cds.
DQ891008 - Synthetic construct clone IMAGE:100003638; FLH168479.01X; RZPDo839H0492D annexin A2 (ANXA2) gene, encodes complete protein.
DQ894187 - Synthetic construct Homo sapiens clone IMAGE:100008647; FLH168475.01L; RZPDo839H0491D annexin A2 (ANXA2) gene, encodes complete protein.
AB587463 - Synthetic construct DNA, clone: pF1KB8277, Homo sapiens ANXA2 gene for annexin A2, without stop codon, in Flexi system.
CU692830 - Synthetic construct Homo sapiens gateway clone IMAGE:100021932 5' read ANXA2 mRNA.
CU679401 - Synthetic construct Homo sapiens gateway clone IMAGE:100019002 5' read ANXA2 mRNA.
CU690914 - Synthetic construct Homo sapiens gateway clone IMAGE:100022447 5' read ANXA2 mRNA.
AK309956 - Homo sapiens cDNA, FLJ99997.
DJ439499 - Annexin II and uses thereof.
DJ439477 - Annexin II and uses thereof.
DJ439521 - Annexin II and uses thereof.
DJ439524 - Annexin II and uses thereof.
JD052275 - Sequence 33299 from Patent EP1572962.
DJ439498 - Annexin II and uses thereof.
DJ439483 - Annexin II and uses thereof.
DJ439515 - Annexin II and uses thereof.
DJ439493 - Annexin II and uses thereof.
DJ439497 - Annexin II and uses thereof.
DJ439501 - Annexin II and uses thereof.
DJ439470 - Annexin II and uses thereof.
DJ439474 - Annexin II and uses thereof.
DJ439513 - Annexin II and uses thereof.
DJ439484 - Annexin II and uses thereof.
DJ439504 - Annexin II and uses thereof.
DJ439512 - Annexin II and uses thereof.
DJ439479 - Annexin II and uses thereof.
DJ439478 - Annexin II and uses thereof.
DJ439476 - Annexin II and uses thereof.
DJ439482 - Annexin II and uses thereof.
DJ439514 - Annexin II and uses thereof.
DJ439453 - Annexin II and uses thereof.
DJ439452 - Annexin II and uses thereof.
DJ439459 - Annexin II and uses thereof.
DJ439457 - Annexin II and uses thereof.
JD372188 - Sequence 353212 from Patent EP1572962.
D28364 - Homo sapiens mRNA for annexin II, 5'UTR region.

-  Other Names for This Gene
  Alternate Gene Symbols: AK309956, ENST00000559559.1, ENST00000559559.2, ENST00000559559.3, ENST00000559559.4, uc010bgj.1, uc010bgj.2, uc010bgj.3, uc010bgj.4
UCSC ID: ENST00000559559.5
RefSeq Accession: NM_004039

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.