Human Gene NUDT7 (ENST00000268533.9) from GENCODE V44
Description: Homo sapiens nudix hydrolase 7 (NUDT7), transcript variant 1, mRNA. (from RefSeq NM_001105663) RefSeq Summary (NM_001105663): The protein encoded by this gene is a member of the Nudix hydrolase family. Nudix hydrolases eliminate potentially toxic nucleotide metabolites from the cell and regulate the concentrations and availability of many different nucleotide substrates, cofactors, and signaling molecules. Alternatively spliced transcript variants encoding multiple isoforms have been found for this gene. [provided by RefSeq, Aug 2011]. Gencode Transcript: ENST00000268533.9 Gencode Gene: ENSG00000140876.11 Transcript (Including UTRs) Position: hg38 chr16:77,722,514-77,742,260 Size: 19,747 Total Exon Count: 4 Strand: + Coding Region Position: hg38 chr16:77,722,583-77,741,950 Size: 19,368 Coding Exon Count: 4
ID:NUDT7_HUMAN DESCRIPTION: RecName: Full=Peroxisomal coenzyme A diphosphatase NUDT7; EC=3.6.1.-; AltName: Full=Nucleoside diphosphate-linked moiety X motif 7; Short=Nudix motif 7; FUNCTION: Coenzyme A diphosphatase which mediates the cleavage of CoA, CoA esters and oxidized CoA with similar efficiencies, yielding 3',5'-ADP and the corresponding 4'-phosphopantetheine derivative as products. CoA into 3',5'-ADP and 4'- phosphopantetheine. Has no activity toward NDP-sugars, CDP- alcohols, (deoxy)nucleoside 5'-triphosphates, nucleoside 5'-di or monophosphates, diadenosine polyphosphates, NAD, NADH, NADP, NADPH or thymidine-5'-monophospho-p-nitrophenyl ester. May be required to eliminate oxidized CoA from peroxisomes, or regulate CoA and acyl-CoA levels in this organelle in response to metabolic demand (By similarity). COFACTOR: Manganese or magnesium (By similarity). ENZYME REGULATION: Inhibited by fluoride (By similarity). SUBCELLULAR LOCATION: Peroxisome (By similarity). TISSUE SPECIFICITY: Expressed in liver, kidney, pancreas, pituitary, small intestine, spleen, heart and placenta. Weakly expressed in brain. SIMILARITY: Belongs to the Nudix hydrolase family. PCD1 subfamily. SIMILARITY: Contains 1 nudix hydrolase domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P0C024
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0006625 protein targeting to peroxisome GO:0008150 biological_process GO:0009062 fatty acid catabolic process GO:0009132 nucleoside diphosphate metabolic process GO:0015938 coenzyme A catabolic process GO:0046356 acetyl-CoA catabolic process GO:0050873 brown fat cell differentiation
US Server
