Human Gene TYMS (ENST00000323274.15) from GENCODE V44
Description: Homo sapiens thymidylate synthetase (TYMS), transcript variant 1, mRNA. (from RefSeq NM_001071) RefSeq Summary (NM_001071): Thymidylate synthase catalyzes the methylation of deoxyuridylate to deoxythymidylate using, 10-methylenetetrahydrofolate (methylene-THF) as a cofactor. This function maintains the dTMP (thymidine-5-prime monophosphate) pool critical for DNA replication and repair. The enzyme has been of interest as a target for cancer chemotherapeutic agents. It is considered to be the primary site of action for 5-fluorouracil, 5-fluoro-2-prime-deoxyuridine, and some folate analogs. Expression of this gene and that of a naturally occurring antisense transcript, mitochondrial enolase superfamily member 1 (GeneID:55556), vary inversely when cell-growth progresses from late-log to plateau phase. Polymorphisms in this gene may be associated with etiology of neoplasia, including breast cancer, and response to chemotherapy. [provided by RefSeq, Aug 2017]. Gencode Transcript: ENST00000323274.15 Gencode Gene: ENSG00000176890.16 Transcript (Including UTRs) Position: hg38 chr18:657,653-673,578 Size: 15,926 Total Exon Count: 7 Strand: + Coding Region Position: hg38 chr18:657,743-672,997 Size: 15,255 Coding Exon Count: 7
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q53Y97
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
BC083512 - Homo sapiens thymidylate synthetase, mRNA (cDNA clone MGC:88736 IMAGE:4299083), complete cds. AK223372 - Homo sapiens mRNA for thymidylate synthetase variant, clone: FCC104A02. BC013919 - Homo sapiens thymidylate synthetase, mRNA (cDNA clone MGC:22884 IMAGE:4048625), complete cds. AB062290 - Homo sapiens OK/SW-cl.29 mRNA for thymidylate synthetase, complete cds. AK314140 - Homo sapiens cDNA, FLJ94841, Homo sapiens thymidylate synthetase (TYMS), mRNA. X02308 - Human mRNA for thymidylate synthase (EC 2.1.1.45). BC002567 - Homo sapiens thymidylate synthetase, mRNA (cDNA clone MGC:1590 IMAGE:3138877), complete cds. BC018858 - Homo sapiens thymidylate synthetase, mRNA (cDNA clone IMAGE:3141419). AK292620 - Homo sapiens cDNA FLJ78114 complete cds, highly similar to Homo sapiens thymidylate synthetase, mRNA. AB590362 - Synthetic construct DNA, clone: pFN21AE1319, Homo sapiens TYMS gene for thymidylate synthetase, without stop codon, in Flexi system. DQ892149 - Synthetic construct clone IMAGE:100004779; FLH183476.01X; RZPDo839C12142D thymidylate synthetase (TYMS) gene, encodes complete protein. AB077207 - Homo sapiens TS mRNA for thymidylate synthase, complete cds, cell_line:MKN45. AB077208 - Homo sapiens TS mRNA for thymidylate synthase, complete cds, cell_line:KATO III. BT006811 - Homo sapiens thymidylate synthetase mRNA, complete cds. JD189860 - Sequence 170884 from Patent EP1572962.
Biochemical and Signaling Pathways
KEGG - Kyoto Encyclopedia of Genes and Genomes hsa00240 - Pyrimidine metabolism hsa00670 - One carbon pool by folate hsa01100 - Metabolic pathways
BioCyc Knowledge Library PWY-7184 - pyrimidine deoxyribonucleotides de novo biosynthesis PWY-7199 - pyrimidine deoxyribonucleosides salvage PWY-7200 - superpathway of pyrimidine deoxyribonucleoside salvage PWY-7210 - pyrimidine deoxyribonucleotides biosynthesis from CTP PWY-7211 - superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis PWY66-385 - dTMP de novo biosynthesis (mitochondrial)
US Server
