Human Gene RLN3 (ENST00000585987.1) from GENCODE V44
  Description: Homo sapiens relaxin 3 (RLN3), transcript variant 2, mRNA. (from RefSeq NM_001311197)
RefSeq Summary (NM_001311197): This gene encodes a member of the relaxin family of insulin-like hormones that is expressed predominantly in the brain and plays a role in physiological processes such as stress, memory and appetite regulation. The encoded protein is a precursor that is proteolytically processed to generate a heterodimeric mature form consisting A and B chains interlinked by disulfide bonds. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2015].
Gencode Transcript: ENST00000585987.1
Gencode Gene: ENSG00000171136.7
Transcript (Including UTRs)
   Position: hg38 chr19:14,028,205-14,030,948 Size: 2,744 Total Exon Count: 3 Strand: +
Coding Region
   Position: hg38 chr19:14,028,205-14,030,737 Size: 2,533 Coding Exon Count: 3 

Page IndexSequence and LinksPrimersCTDRNA-Seq ExpressionMicroarray Expression
RNA StructureOther SpeciesmRNA DescriptionsOther NamesMethods
Data last updated at UCSC: 2023-08-18 00:09:47

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr19:14,028,205-14,030,948)mRNA (may differ from genome)Protein (109 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGencodeGeneCards
HGNCLynxMGIOMIMPubMedUniProtKB
BioGrid CRISPR DB

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 1.04 RPKM in Testis
Total median expression: 2.00 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
3' UTR -92.10211-0.436 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
MGIRGD    
Protein SequenceProtein Sequence    
AlignmentAlignment    

-  Descriptions from all associated GenBank mRNAs
  AY358181 - Homo sapiens clone DNA171372 RLN3 (UNQ6188) mRNA, complete cds.
BC140935 - Homo sapiens relaxin 3, mRNA (cDNA clone MGC:176612 IMAGE:9056747), complete cds.
KJ904968 - Synthetic construct Homo sapiens clone ccsbBroadEn_14362 RLN3 gene, encodes complete protein.
AF447451 - Homo sapiens relaxin 3 (RLN3) mRNA, complete cds.
BC110069 - Homo sapiens relaxin 3, mRNA (cDNA clone IMAGE:40014224).
AB076563 - Homo sapiens insl7 mRNA for insulin-like 7, complete cds.

-  Other Names for This Gene
  Alternate Gene Symbols: K7ENX1, NM_001311197, uc010dzj.1, uc010dzj.2
UCSC ID: ENST00000585987.1
RefSeq Accession: NM_001311197
CCDS: CCDS82304.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.