Human Gene CMKLR2 (ENST00000437420.5) from GENCODE V44
  Description: Homo sapiens G protein-coupled receptor 1 (GPR1), transcript variant 4, mRNA. (from RefSeq NM_001261453)
Gencode Transcript: ENST00000437420.5
Gencode Gene: ENSG00000183671.13
Transcript (Including UTRs)
   Position: hg38 chr2:206,176,180-206,217,903 Size: 41,724 Total Exon Count: 4 Strand: -
Coding Region
   Position: hg38 chr2:206,176,180-206,177,247 Size: 1,068 Coding Exon Count: 1 

Page IndexSequence and LinksUniProtKB CommentsPrimersRNA-Seq ExpressionMicroarray Expression
RNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA DescriptionsOther Names
Methods
Data last updated at UCSC: 2023-08-18 00:09:47

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr2:206,176,180-206,217,903)mRNA (may differ from genome)Protein (355 aa)
Gene SorterGenome BrowserOther Species FASTATable SchemaAlphaFoldBioGPS
EnsemblEntrez GeneExonPrimerGencodeGeneCardsHPRD
LynxMalacardsMGIneXtProtOMIMPubMed
UniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: GPR1_HUMAN
DESCRIPTION: RecName: Full=G-protein coupled receptor 1;
FUNCTION: Receptor for the inflammation-associated leukocyte chemoattractant chemerin/RARRES2 suggesting a role for this receptor in the regulation of inflammation. Can act as a coreceptor for HIV-1.
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
TISSUE SPECIFICITY: Expressed in hippocampus.
SIMILARITY: Belongs to the G-protein coupled receptor 1 family.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 5.24 RPKM in Cells - Cultured fibroblasts
Total median expression: 21.88 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -138.10489-0.282 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR000276 - 7TM_GPCR_Rhodpsn
IPR017452 - GPCR_Rhodpsn_supfam
IPR002275 - GPR1_rcpt

Pfam Domains:
PF00001 - 7 transmembrane receptor (rhodopsin family)

ModBase Predicted Comparative 3D Structure on P46091
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
MGIRGD    
Protein SequenceProtein Sequence    
AlignmentAlignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0004871 signal transducer activity
GO:0004930 G-protein coupled receptor activity
GO:0005515 protein binding
GO:0042923 neuropeptide binding

Biological Process:
GO:0007165 signal transduction
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007187 G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
GO:0007218 neuropeptide signaling pathway
GO:0007268 chemical synaptic transmission

Cellular Component:
GO:0005654 nucleoplasm
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0043005 neuron projection
GO:0043231 intracellular membrane-bounded organelle


-  Descriptions from all associated GenBank mRNAs
  AK075130 - Homo sapiens cDNA FLJ90649 fis, clone PLACE1004441, highly similar to Probable G-protein coupled receptor 1.
BC067833 - Homo sapiens G protein-coupled receptor 1, mRNA (cDNA clone MGC:87403 IMAGE:30334911), complete cds.
LF383614 - JP 2014500723-A/191117: Polycomb-Associated Non-Coding RNAs.
MA619191 - JP 2018138019-A/191117: Polycomb-Associated Non-Coding RNAs.
BC058005 - Homo sapiens G protein-coupled receptor 1, mRNA (cDNA clone IMAGE:4605394).
AK290976 - Homo sapiens cDNA FLJ78015 complete cds, highly similar to Homo sapiens G protein-coupled receptor 1 (GPR1), mRNA.
EF577403 - Homo sapiens G protein-coupled receptor 1 mRNA, complete cds.
AK312917 - Homo sapiens cDNA, FLJ93366.
AB464539 - Synthetic construct DNA, clone: pF1KB9839, Homo sapiens GPR1 gene for G protein-coupled receptor 1, without stop codon, in Flexi system.
JD535409 - Sequence 516433 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: A5JUU6, A8K4L1, ENST00000437420.1, ENST00000437420.2, ENST00000437420.3, ENST00000437420.4, GPR1, GPR1_HUMAN, NM_001261453, P46091, Q53TR9, Q6NVX4, uc010fuf.1, uc010fuf.2, uc010fuf.3, uc010fuf.4, uc010fuf.5
UCSC ID: ENST00000437420.5
RefSeq Accession: NM_001261452
Protein: P46091 (aka GPR1_HUMAN)
CCDS: CCDS2368.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.