Human Gene ZMYND10 (ENST00000442887.1) from GENCODE V44
  Description: The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data. (from UniProt C9JUQ8)
RefSeq Summary (NM_015896): This gene encodes a protein containing a MYND-type zinc finger domain that likely functions in assembly of the dynein motor. Mutations in this gene can cause primary ciliary dyskinesia. This gene is also considered a tumor suppressor gene and is often mutated, deleted, or hypermethylated and silenced in cancer cells. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2015].
Gencode Transcript: ENST00000442887.1
Gencode Gene: ENSG00000004838.14
Transcript (Including UTRs)
   Position: hg38 chr3:50,342,037-50,345,721 Size: 3,685 Total Exon Count: 9 Strand: -
Coding Region
   Position: hg38 chr3:50,342,037-50,345,195 Size: 3,159 Coding Exon Count: 8 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesmRNA Descriptions
Other NamesGeneReviewsMethods
Data last updated at UCSC: 2023-08-18 00:09:47

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr3:50,342,037-50,345,721)mRNA (may differ from genome)Protein (282 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblExonPrimerGencodeGeneCardsHGNC
LynxMalacardsMGIPubMedUniProtKBWikipedia

-  Comments and Description Text from UniProtKB
  ID: C9JUQ8_HUMAN
DESCRIPTION: SubName: Full=Zinc finger MYND domain-containing protein 10; Flags: Fragment;
CAUTION: The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: ZMYND10
Diseases sorted by gene-association score: ciliary dyskinesia, primary, 22* (1230), primary ciliary dyskinesia 22: zmynd10-related primary ciliary dyskinesia* (500), kartagener syndrome* (187), primary ciliary dyskinesia* (135), ciliary dyskinesia, primary, 1, with or without situs inversus* (121), choroid plexus papilloma (12), ovarian serous carcinoma (9), nasopharyngeal carcinoma (8)
* = Manually curated disease association

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 168.27 RPKM in Testis
Total median expression: 208.42 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -78.70224-0.351 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  ModBase Predicted Comparative 3D Structure on C9JUQ8
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
MGIRGD    
Protein SequenceProtein Sequence    
AlignmentAlignment    

-  Descriptions from all associated GenBank mRNAs
  AB209621 - Homo sapiens mRNA for zinc finger, MYND domain-containing 10 variant protein.
AK058135 - Homo sapiens cDNA FLJ25406 fis, clone TST02903, highly similar to Human BLu protein mRNA.
AK223343 - Homo sapiens mRNA for zinc finger, MYND domain-containing 10 variant, clone: TST02358.
BC022186 - Homo sapiens cDNA clone IMAGE:4826736, containing frame-shift errors.
BC033732 - Homo sapiens zinc finger, MYND-type containing 10, mRNA (cDNA clone MGC:45111 IMAGE:5168611), complete cds.
U70880 - Human BLu protein testis isoform (BLu) mRNA, complete cds.
AK093455 - Homo sapiens cDNA FLJ36136 fis, clone TESTI2024744, moderately similar to Human BLu protein testis isoform (BLu) mRNA.
AX748138 - Sequence 1663 from Patent EP1308459.
U70824 - Human BLu protein (BLu) mRNA, complete cds.
AK096525 - Homo sapiens cDNA FLJ39206 fis, clone OCBBF2005901, highly similar to Zinc finger MYND domain-containing protein 10.
AL833828 - Homo sapiens mRNA; cDNA DKFZp566B163 (from clone DKFZp566B163).
AK315123 - Homo sapiens cDNA, FLJ96086.
KJ898885 - Synthetic construct Homo sapiens clone ccsbBroadEn_08279 ZMYND10 gene, encodes complete protein.
AB464423 - Synthetic construct DNA, clone: pF1KB8335, Homo sapiens ZMYND10 gene for zinc finger, MYND-type containing protein 10, without stop codon, in Flexi system.
AM392817 - Synthetic construct Homo sapiens clone IMAGE:100002202 for hypothetical protein (ZMYND10 gene).
AM393187 - Synthetic construct Homo sapiens clone IMAGE:100002203 for hypothetical protein (ZMYND10 gene).
AK308086 - Homo sapiens cDNA, FLJ98034.
CU689716 - Synthetic construct Homo sapiens gateway clone IMAGE:100018295 5' read ZMYND10 mRNA.

-  Other Names for This Gene
  Alternate Gene Symbols: AK096525, C9JUQ8, C9JUQ8_HUMAN, uc010hlm.1, uc010hlm.2
UCSC ID: ENST00000442887.1
RefSeq Accession: NM_015896
Protein: C9JUQ8

-  GeneReviews for This Gene
  GeneReviews article(s) related to gene ZMYND10:
pcd (Primary Ciliary Dyskinesia)

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.