Human Gene SLC10A7 (ENST00000432059.6) from GENCODE V44
  Description: Homo sapiens solute carrier family 10 member 7 (SLC10A7), transcript variant 5, mRNA. (from RefSeq NM_001317816)
Gencode Transcript: ENST00000432059.6
Gencode Gene: ENSG00000120519.16
Transcript (Including UTRs)
   Position: hg38 chr4:146,253,975-146,521,964 Size: 267,990 Total Exon Count: 11 Strand: -
Coding Region
   Position: hg38 chr4:146,256,491-146,521,717 Size: 265,227 Coding Exon Count: 11 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
Other NamesMethods
Data last updated at UCSC: 2023-08-18 00:09:47

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr4:146,253,975-146,521,964)mRNA (may differ from genome)Protein (327 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGencodeGeneCards
HGNCHPRDLynxMalacardsMGIneXtProt
OMIMPubMedUniProtKBWikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: NTCP7_HUMAN
DESCRIPTION: RecName: Full=Sodium/bile acid cotransporter 7; AltName: Full=Na(+)/bile acid cotransporter 7; AltName: Full=Solute carrier family 10 member 7;
SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein (Potential).
SIMILARITY: Belongs to the unknown BART superfamily-1 (UBS1) (TC 2.A.93) family.
SEQUENCE CAUTION: Sequence=BAC11571.1; Type=Erroneous initiation;

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 3.15 RPKM in Cells - EBV-transformed lymphocytes
Total median expression: 64.00 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -61.50247-0.249 Picture PostScript Text
3' UTR -530.702516-0.211 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR016833 - Put_Na-Bile_cotransptr

Pfam Domains:
PF13593 - SBF-like CPA transporter family (DUF4137)

ModBase Predicted Comparative 3D Structure on Q0GE19
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
MGIRGD    
Protein SequenceProtein Sequence    
AlignmentAlignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0015293 symporter activity

Biological Process:
GO:0006811 ion transport
GO:0006814 sodium ion transport
GO:0055085 transmembrane transport

Cellular Component:
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane


-  Descriptions from all associated GenBank mRNAs
  EU831740 - Synthetic construct Homo sapiens clone HAIB:100066769; DKFZo003G0820 solute carrier family 10 (sodium/bile acid cotransporter family), member 7 protein (SLC10A7) gene, encodes complete protein.
EU831744 - Synthetic construct Homo sapiens clone HAIB:100066773; DKFZo003H0220 solute carrier family 10 (sodium/bile acid cotransporter family), member 7 protein (SLC10A7) gene, encodes complete protein.
AK075364 - Homo sapiens cDNA PSEC0051 fis, clone NT2RP2000168.
CR933647 - Homo sapiens mRNA; cDNA DKFZp313H0531 (from clone DKFZp313H0531).
BC150308 - Homo sapiens solute carrier family 10 (sodium/bile acid cotransporter family), member 7, mRNA (cDNA clone MGC:167104 IMAGE:8860437), complete cds.
AK126000 - Homo sapiens cDNA FLJ44012 fis, clone TESTI4024874, highly similar to Rattus norvegicus solute carrier family 10 (sodium/bile acid cotransporter family), member 7 (Slc10a7), mRNA.
CR936751 - Homo sapiens mRNA; cDNA DKFZp779O2438 (from clone DKFZp779O2438).
AK172727 - Homo sapiens cDNA PSEC0026 fis, clone: NT2RP1000434.
AY346324 - Homo sapiens SBF-domain containing protein mRNA, complete cds.
AK291046 - Homo sapiens cDNA FLJ77110 complete cds.
EU831657 - Synthetic construct Homo sapiens clone HAIB:100066686; DKFZo007G0819 solute carrier family 10 (sodium/bile acid cotransporter family), member 7 protein (SLC10A7) gene, encodes complete protein.
EU831663 - Synthetic construct Homo sapiens clone HAIB:100066692; DKFZo007H0219 solute carrier family 10 (sodium/bile acid cotransporter family), member 7 protein (SLC10A7) gene, encodes complete protein.
DQ122860 - Homo sapiens P7 isoform a (P7) mRNA, complete cds.
DQ122861 - Homo sapiens P7 isoform b (P7) mRNA, complete cds.
DQ871036 - Homo sapiens P7 isoform c (P7) mRNA, complete cds.
KJ903379 - Synthetic construct Homo sapiens clone ccsbBroadEn_12773 SLC10A7 gene, encodes complete protein.
BC063471 - Homo sapiens solute carrier family 10 (sodium/bile acid cotransporter family), member 7, mRNA (cDNA clone IMAGE:5210212), complete cds.
AL136728 - Homo sapiens mRNA; cDNA DKFZp566M114 (from clone DKFZp566M114).
BC148252 - Homo sapiens solute carrier family 10 (sodium/bile acid cotransporter family), member 7, mRNA (cDNA clone IMAGE:40115393), complete cds.
BC120970 - Homo sapiens solute carrier family 10 (sodium/bile acid cotransporter family), member 7, mRNA (cDNA clone IMAGE:40115389), complete cds.
BC120971 - Homo sapiens solute carrier family 10 (sodium/bile acid cotransporter family), member 7, mRNA (cDNA clone IMAGE:40115390), complete cds.
BC127626 - Homo sapiens solute carrier family 10 (sodium/bile acid cotransporter family), member 7, mRNA (cDNA clone IMAGE:40115391), complete cds.
BC127627 - Homo sapiens solute carrier family 10 (sodium/bile acid cotransporter family), member 7, mRNA (cDNA clone IMAGE:40115392), complete cds.
CU687734 - Synthetic construct Homo sapiens gateway clone IMAGE:100021619 5' read SLC10A7 mRNA.
KJ906356 - Synthetic construct Homo sapiens clone ccsbBroadEn_16026 SLC10A7 gene, encodes complete protein.
AM392861 - Synthetic construct Homo sapiens clone IMAGE:100001804 for hypothetical protein (C4orf13 gene).
BC146684 - Synthetic construct Homo sapiens clone IMAGE:100001804, MGC:165120 solute carrier family 10 (sodium/bile acid cotransporter family), member 7 (SLC10A7) mRNA, encodes complete protein.
BC023288 - Homo sapiens solute carrier family 10 (sodium/bile acid cotransporter family), member 7, mRNA (cDNA clone IMAGE:4475169), complete cds.
KJ903378 - Synthetic construct Homo sapiens clone ccsbBroadEn_12772 SLC10A7 gene, encodes complete protein.
JD251078 - Sequence 232102 from Patent EP1572962.
JD423925 - Sequence 404949 from Patent EP1572962.
JD363195 - Sequence 344219 from Patent EP1572962.
JD205388 - Sequence 186412 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: A7E2E6, A7MAX9, C4orf13, ENST00000432059.1, ENST00000432059.2, ENST00000432059.3, ENST00000432059.4, ENST00000432059.5, NM_001317816, NTCP7_HUMAN, P7, PSEC0051, Q0GE19, Q0VAP9, Q45NG1, Q45NG2, Q5H9S6, Q6P4E6, Q8IZ62, Q8NBP8, Q9H0M9, uc010ipa.1, uc010ipa.2, uc010ipa.3
UCSC ID: ENST00000432059.6
RefSeq Accession: NM_001317816
Protein: Q0GE19 (aka NTCP7_HUMAN)
CCDS: CCDS34073.1, CCDS82963.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.