Human Gene TMEM174 (ENST00000296776.6) from GENCODE V49

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Description: transmembrane protein 174 (from RefSeq NM_153217.3)
Gencode Transcript: ENST00000296776.6
Gencode Gene: ENSG00000164325.8
Transcript (Including UTRs)
Position: hg38 chr5:73,173,193-73,175,143 Size: 1,951 Total Exon Count: 2 Strand: +
Coding Region
Position: hg38 chr5:73,173,244-73,174,165 Size: 922 Coding Exon Count: 2

Page Index	Sequence and Links	UniProtKB Comments	Primers	MalaCards	CTD
RNA-Seq Expression	Microarray Expression	RNA Structure	Protein Structure	Other Species	GO Annotations
mRNA Descriptions	Other Names	Methods

Data last updated at UCSC: 2025-09-17 13:57:07

Sequence and Links to Tools and Databases

Genomic Sequence (chr5:73,173,193-73,175,143)			mRNA (may differ from genome)		Protein (243 aa)
Gene Sorter	Genome Browser	Other Species FASTA	Gene interactions	Table Schema	AlphaFold
BioGPS	Ensembl	Entrez Gene	ExonPrimer	Gencode	GeneCards
HGNC	Lynx	Malacards	MGI	OMIM	PubMed
UniProtKB	BioGrid CRISPR DB

Comments and Description Text from UniProtKB


	ID: TM174_HUMAN DESCRIPTION: RecName: Full=Transmembrane protein 174; SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein (Potential).

Primer design for this transcript

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

MalaCards Disease Associations


	MalaCards Gene Search: TMEM174 Diseases sorted by gene-association score: renal cell carcinoma, papillary (1)

Comparative Toxicogenomics Database (CTD)


	The following chemicals interact with this gene D000535 Aluminum D019327 Copper Sulfate C006780 bisphenol A

RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)


	Highest median expression: 6.29 RPKM in Kidney - Cortex Total median expression: 6.43 RPKM View in GTEx track of Genome Browser View at GTEx portal View GTEx Body Map

Microarray Expression Data


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mRNA Secondary Structure of 3' and 5' UTRs

Region	Fold Energy	Bases	Energy/Base	Display As
5' UTR	-10.80	51	-0.212	Picture	PostScript	Text
3' UTR	-300.60	978	-0.307	Picture	PostScript	Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

Protein Domain and Structure Information

ModBase Predicted Comparative 3D Structure on Q8WUU8


Front	Top	Side

The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

Orthologous Genes in Other Species

Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.

Mouse	Rat	Zebrafish	D. melanogaster	C. elegans	S. cerevisiae
Genome Browser	Genome Browser	Genome Browser	No ortholog	No ortholog	No ortholog
Gene Details
Gene Sorter
MGI	RGD	Ensembl
Protein Sequence	Protein Sequence	Protein Sequence
Alignment	Alignment	Alignment

Gene Ontology (GO) Annotations with Structured Vocabulary


	Molecular Function: GO:0005515 protein binding Cellular Component: GO:0005783 endoplasmic reticulum GO:0005789 endoplasmic reticulum membrane GO:0016020 membrane GO:0016021 integral component of membrane

Descriptions from all associated GenBank mRNAs


	BC019346 - Homo sapiens transmembrane protein 174, mRNA (cDNA clone MGC:13034 IMAGE:3613225), complete cds. AK315460 - Homo sapiens cDNA, FLJ96519. AK055830 - Homo sapiens cDNA FLJ31268 fis, clone KIDNE2006062. JF432630 - Synthetic construct Homo sapiens clone IMAGE:100073867 transmembrane protein 174 (TMEM174) gene, encodes complete protein. KJ895497 - Synthetic construct Homo sapiens clone ccsbBroadEn_04891 TMEM174 gene, encodes complete protein. JD082854 - Sequence 63878 from Patent EP1572962. JD234848 - Sequence 215872 from Patent EP1572962. JD388554 - Sequence 369578 from Patent EP1572962. JD481871 - Sequence 462895 from Patent EP1572962. JD241992 - Sequence 223016 from Patent EP1572962. JD175397 - Sequence 156421 from Patent EP1572962. JD257263 - Sequence 238287 from Patent EP1572962. JD342776 - Sequence 323800 from Patent EP1572962. JD135517 - Sequence 116541 from Patent EP1572962. JD303282 - Sequence 284306 from Patent EP1572962.

Other Names for This Gene


	Alternate Gene Symbols: B2RDA0, ENST00000296776.1, ENST00000296776.2, ENST00000296776.3, ENST00000296776.4, ENST00000296776.5, NM_153217, Q8WUU8, Q96N81, TM174_HUMAN, uc010izc.1, uc010izc.2, uc010izc.3, uc010izc.4, uc010izc.5 UCSC ID: ENST00000296776.6 RefSeq Accession: NM_153217.3 Protein: Q8WUU8 (aka TM174_HUMAN) CCDS: CCDS4018.1

Methods, Credits, and Use Restrictions


	Click here for details on how this gene model was made and data restrictions if any.