Human Gene TMEM170B (ENST00000379426.2) from GENCODE V49
  Description: transmembrane protein 170B (from RefSeq NM_001100829.3)
Gencode Transcript: ENST00000379426.2
Gencode Gene: ENSG00000205269.7
Transcript (Including UTRs)
   Position: hg38 chr6:11,537,749-11,583,524 Size: 45,776 Total Exon Count: 3 Strand: +
Coding Region
   Position: hg38 chr6:11,538,278-11,575,561 Size: 37,284 Coding Exon Count: 3 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDRNA-Seq Expression
RNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA DescriptionsOther Names
Methods
Data last updated at UCSC: 2025-09-17 13:57:07

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr6:11,537,749-11,583,524)mRNA (may differ from genome)Protein (132 aa)
Gene SorterGenome BrowserOther Species FASTATable SchemaAlphaFoldBioGPS
EnsemblEntrez GeneExonPrimerGencodeGeneCardsHGNC
LynxMalacardsMGIPubMedUniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: T170B_HUMAN
DESCRIPTION: RecName: Full=Transmembrane protein 170B;
SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein (Potential).
SIMILARITY: Belongs to the TMEM170 family.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 7.28 RPKM in Brain - Cerebellar Hemisphere
Total median expression: 128.87 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -317.40529-0.600 Picture PostScript Text
3' UTR -1957.507963-0.246 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR019334 - Transmembrane_pr_170

Pfam Domains:
PF10190 - Putative transmembrane protein 170

ModBase Predicted Comparative 3D Structure on Q5T4T1
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserGenome BrowserGenome BrowserNo orthologNo ortholog
Gene Details     
Gene Sorter     
MGIRGDEnsemblEnsembl  
Protein SequenceProtein SequenceProtein SequenceProtein Sequence  
AlignmentAlignmentAlignmentAlignment  

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005515 protein binding

Biological Process:
GO:0090090 negative regulation of canonical Wnt signaling pathway

Cellular Component:
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane


-  Descriptions from all associated GenBank mRNAs
  DL492412 - Novel nucleic acids.
DL490892 - Novel nucleic acids.
LF209763 - JP 2014500723-A/17266: Polycomb-Associated Non-Coding RNAs.
MA445340 - JP 2018138019-A/17266: Polycomb-Associated Non-Coding RNAs.
LF331555 - JP 2014500723-A/139058: Polycomb-Associated Non-Coding RNAs.
MA567132 - JP 2018138019-A/139058: Polycomb-Associated Non-Coding RNAs.
LF331557 - JP 2014500723-A/139060: Polycomb-Associated Non-Coding RNAs.
MA567134 - JP 2018138019-A/139060: Polycomb-Associated Non-Coding RNAs.
LF209764 - JP 2014500723-A/17267: Polycomb-Associated Non-Coding RNAs.
MA445341 - JP 2018138019-A/17267: Polycomb-Associated Non-Coding RNAs.
LF331558 - JP 2014500723-A/139061: Polycomb-Associated Non-Coding RNAs.
MA567135 - JP 2018138019-A/139061: Polycomb-Associated Non-Coding RNAs.
LF331559 - JP 2014500723-A/139062: Polycomb-Associated Non-Coding RNAs.
MA567136 - JP 2018138019-A/139062: Polycomb-Associated Non-Coding RNAs.
DQ570879 - Homo sapiens piRNA piR-30991, complete sequence.
LF331560 - JP 2014500723-A/139063: Polycomb-Associated Non-Coding RNAs.
MA567137 - JP 2018138019-A/139063: Polycomb-Associated Non-Coding RNAs.
LF331561 - JP 2014500723-A/139064: Polycomb-Associated Non-Coding RNAs.
MA567138 - JP 2018138019-A/139064: Polycomb-Associated Non-Coding RNAs.
JD026219 - Sequence 7243 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000379426.1, NM_001100829, Q5T4T1, T170B_HUMAN, uc010jpa.1, uc010jpa.2, uc010jpa.3, uc010jpa.4, uc010jpa.5, uc010jpa.6
UCSC ID: ENST00000379426.2
RefSeq Accession: NM_001100829.3
Protein: Q5T4T1 (aka T170B_HUMAN)
CCDS: CCDS43425.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.