Human Gene NRSN1 (ENST00000378478.5) from GENCODE V44
Description: May play an important role in neural organelle transport, and in transduction of nerve signals or in nerve growth. May play a role in neurite extension. (from UniProt Q8IZ57) Gencode Transcript: ENST00000378478.5 Gencode Gene: ENSG00000152954.12 Transcript (Including UTRs) Position: hg38 chr6:24,126,186-24,147,529 Size: 21,344 Total Exon Count: 4 Strand: + Coding Region Position: hg38 chr6:24,134,328-24,145,946 Size: 11,619 Coding Exon Count: 2
ID:NRSN1_HUMAN DESCRIPTION: RecName: Full=Neurensin-1; AltName: Full=Neuro-p24; AltName: Full=Vesicular membrane protein of 24 kDa; Short=Vesicular membrane protein p24; FUNCTION: May play an important role in neural organelle transport, and in transduction of nerve signals or in nerve growth. May play a role in neurite extension. SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein (Potential). Note=Localizes mainly to neurites. TISSUE SPECIFICITY: Expressed in brain. Not detectable in other tissues tested. SIMILARITY: Belongs to the VMP family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Protein Domain and Structure Information
ModBase Predicted Comparative 3D Structure on Q8IZ57
Front
Top
Side
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.