Human Gene NRSN1 (ENST00000378478.5) from GENCODE V44
  Description: May play an important role in neural organelle transport, and in transduction of nerve signals or in nerve growth. May play a role in neurite extension. (from UniProt Q8IZ57)
Gencode Transcript: ENST00000378478.5
Gencode Gene: ENSG00000152954.12
Transcript (Including UTRs)
   Position: hg38 chr6:24,126,186-24,147,529 Size: 21,344 Total Exon Count: 4 Strand: +
Coding Region
   Position: hg38 chr6:24,134,328-24,145,946 Size: 11,619 Coding Exon Count: 2 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesMethods
Data last updated at UCSC: 2023-08-18 00:09:47

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr6:24,126,186-24,147,529)mRNA (may differ from genome)Protein (195 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblExonPrimerGencodeGeneCardsHGNC
HPRDLynxMalacardsMGImyGene2neXtProt
PubMedUniProtKBWikipedia

-  Comments and Description Text from UniProtKB
  ID: NRSN1_HUMAN
DESCRIPTION: RecName: Full=Neurensin-1; AltName: Full=Neuro-p24; AltName: Full=Vesicular membrane protein of 24 kDa; Short=Vesicular membrane protein p24;
FUNCTION: May play an important role in neural organelle transport, and in transduction of nerve signals or in nerve growth. May play a role in neurite extension.
SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein (Potential). Note=Localizes mainly to neurites.
TISSUE SPECIFICITY: Expressed in brain. Not detectable in other tissues tested.
SIMILARITY: Belongs to the VMP family.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: NRSN1
Diseases sorted by gene-association score: louse-borne relapsing fever (2)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 34.57 RPKM in Brain - Frontal Cortex (BA9)
Total median expression: 231.00 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -80.30237-0.339 Picture PostScript Text
3' UTR -400.401583-0.253 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  ModBase Predicted Comparative 3D Structure on Q8IZ57
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
MGIRGD    
Protein SequenceProtein Sequence    
AlignmentAlignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005515 protein binding

Biological Process:
GO:0007399 nervous system development

Cellular Component:
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0030133 transport vesicle
GO:0030426 growth cone
GO:0031410 cytoplasmic vesicle
GO:0043005 neuron projection
GO:0043025 neuronal cell body


-  Descriptions from all associated GenBank mRNAs
  AK096290 - Homo sapiens cDNA FLJ38971 fis, clone NT2RI2002540, highly similar to Mouse mRNA for P24 protein.
JD281296 - Sequence 262320 from Patent EP1572962.
AK314373 - Homo sapiens cDNA, FLJ95145, highly similar to Homo sapiens vesicular membrane protein p24 (VMP), mRNA.
AK311178 - Homo sapiens cDNA, FLJ18220.
AK225775 - Homo sapiens mRNA for vesicular membrane protein p24 variant, clone: FCC132E11.
AF418980 - Homo sapiens vesicular membrane protein P24 mRNA, complete cds.
BC023514 - Homo sapiens neurensin 1, mRNA (cDNA clone MGC:12874 IMAGE:4128341), complete cds.
AL833257 - Homo sapiens mRNA; cDNA DKFZp761M1520 (from clone DKFZp761M1520).
BC067291 - Homo sapiens cDNA clone IMAGE:30368220, partial cds.
JD077183 - Sequence 58207 from Patent EP1572962.
JD182437 - Sequence 163461 from Patent EP1572962.
DQ893395 - Synthetic construct clone IMAGE:100006025; FLH199470.01X; RZPDo839C0282D neurensin 1 (NRSN1) gene, encodes complete protein.
DQ896717 - Synthetic construct Homo sapiens clone IMAGE:100011177; FLH199376.01L; RZPDo839C0281D neurensin 1 (NRSN1) gene, encodes complete protein.
EU832383 - Synthetic construct Homo sapiens clone HAIB:100067412; DKFZo004C0228 neurensin 1 protein (NRSN1) gene, encodes complete protein.
KJ895554 - Synthetic construct Homo sapiens clone ccsbBroadEn_04948 NRSN1 gene, encodes complete protein.
EU832299 - Synthetic construct Homo sapiens clone HAIB:100067328; DKFZo008C0227 neurensin 1 protein (NRSN1) gene, encodes complete protein.
JD517229 - Sequence 498253 from Patent EP1572962.
JD158472 - Sequence 139496 from Patent EP1572962.
JD095349 - Sequence 76373 from Patent EP1572962.
JD549195 - Sequence 530219 from Patent EP1572962.
JD089153 - Sequence 70177 from Patent EP1572962.
JD516032 - Sequence 497056 from Patent EP1572962.
JD393025 - Sequence 374049 from Patent EP1572962.
JD288279 - Sequence 269303 from Patent EP1572962.
JD267066 - Sequence 248090 from Patent EP1572962.
JD297750 - Sequence 278774 from Patent EP1572962.
JD501070 - Sequence 482094 from Patent EP1572962.
JD557052 - Sequence 538076 from Patent EP1572962.
JD293762 - Sequence 274786 from Patent EP1572962.
JD409539 - Sequence 390563 from Patent EP1572962.
JD046301 - Sequence 27325 from Patent EP1572962.
JD402629 - Sequence 383653 from Patent EP1572962.
JD130206 - Sequence 111230 from Patent EP1572962.
JD494104 - Sequence 475128 from Patent EP1572962.
JD360462 - Sequence 341486 from Patent EP1572962.
JD260294 - Sequence 241318 from Patent EP1572962.
JD491951 - Sequence 472975 from Patent EP1572962.
JD539106 - Sequence 520130 from Patent EP1572962.
JD346339 - Sequence 327363 from Patent EP1572962.
JD195274 - Sequence 176298 from Patent EP1572962.
JD050932 - Sequence 31956 from Patent EP1572962.
JD360158 - Sequence 341182 from Patent EP1572962.
JD289818 - Sequence 270842 from Patent EP1572962.
JD420708 - Sequence 401732 from Patent EP1572962.
JD247617 - Sequence 228641 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: AK096290, B2RAV4, ENST00000378478.1, ENST00000378478.2, ENST00000378478.3, ENST00000378478.4, NRSN1_HUMAN, Q8IZ57, Q8N8R6, Q96P21, uc010jpq.1, VMP
UCSC ID: ENST00000378478.5
RefSeq Accession: NM_080723
Protein: Q8IZ57 (aka NRSN1_HUMAN)
CCDS: CCDS4549.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.