Human Gene TMEM200A (ENST00000545622.5) from GENCODE V44
  Description: Homo sapiens transmembrane protein 200A (TMEM200A), transcript variant 3, mRNA. (from RefSeq NM_001258278)
Gencode Transcript: ENST00000545622.5
Gencode Gene: ENSG00000164484.12
Transcript (Including UTRs)
   Position: hg38 chr6:130,421,096-130,443,061 Size: 21,966 Total Exon Count: 2 Strand: +
Coding Region
   Position: hg38 chr6:130,440,423-130,441,898 Size: 1,476 Coding Exon Count: 1 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
Other NamesMethods
Data last updated at UCSC: 2023-08-18 00:09:47

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr6:130,421,096-130,443,061)mRNA (may differ from genome)Protein (491 aa)
Gene SorterGenome BrowserOther Species FASTATable SchemaAlphaFoldBioGPS
EnsemblEntrez GeneExonPrimerGencodeGeneCardsHGNC
LynxMGIneXtProtPubMedUniProtKBWikipedia
BioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: T200A_HUMAN
DESCRIPTION: RecName: Full=Transmembrane protein 200A;
SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein (Potential).
TISSUE SPECIFICITY: Expressed in cerebellum.
SIMILARITY: Belongs to the TMEM200 family.
SEQUENCE CAUTION: Sequence=BAB67806.1; Type=Erroneous initiation;

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 7.13 RPKM in Uterus
Total median expression: 68.90 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -82.60279-0.296 Picture PostScript Text
3' UTR -228.001163-0.196 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR018787 - DUF2371_TMEM200

Pfam Domains:
PF10177 - Uncharacterised conserved protein (DUF2371)

ModBase Predicted Comparative 3D Structure on Q86VY9
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
MGIRGD    
Protein SequenceProtein Sequence    
AlignmentAlignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Cellular Component:
GO:0016020 membrane
GO:0016021 integral component of membrane


-  Descriptions from all associated GenBank mRNAs
  AB067500 - Homo sapiens mRNA for KIAA1913 protein.
AK315824 - Homo sapiens cDNA, FLJ79473 complete cds.
BC044246 - Homo sapiens transmembrane protein 200A, mRNA (cDNA clone MGC:50847 IMAGE:5760073), complete cds.
AK290166 - Homo sapiens cDNA FLJ75079 complete cds.
AB052099 - Homo sapiens mRNA for HBE61, complete cds.
AB385516 - Synthetic construct DNA, clone: pF1KA1913, Homo sapiens KIAA1913 gene for KIAA1913 protein, complete cds, without stop codon, in Flexi system.
KJ900007 - Synthetic construct Homo sapiens clone ccsbBroadEn_09401 TMEM200A gene, encodes complete protein.
AK294359 - Homo sapiens cDNA FLJ52599 complete cds.
JD359340 - Sequence 340364 from Patent EP1572962.
JD226300 - Sequence 207324 from Patent EP1572962.
JD347561 - Sequence 328585 from Patent EP1572962.
JD064999 - Sequence 46023 from Patent EP1572962.
JD063669 - Sequence 44693 from Patent EP1572962.
JD491375 - Sequence 472399 from Patent EP1572962.
JD245305 - Sequence 226329 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000545622.1, ENST00000545622.2, ENST00000545622.3, ENST00000545622.4, HBE61, KIAA1913, NM_001258278, Q86VY9, Q96PX5, T200A_HUMAN, uc010kfi.1, uc010kfi.2, uc010kfi.3, uc010kfi.4, uc010kfi.5
UCSC ID: ENST00000545622.5
RefSeq Accession: NM_001258278
Protein: Q86VY9 (aka T200A_HUMAN)
CCDS: CCDS5140.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.