Human Gene FAM131B (ENST00000443739.7) from GENCODE V44
  Description: Homo sapiens family with sequence similarity 131 member B (FAM131B), transcript variant a, mRNA. (from RefSeq NM_001031690)
Gencode Transcript: ENST00000443739.7
Gencode Gene: ENSG00000159784.18
Transcript (Including UTRs)
   Position: hg38 chr7:143,353,400-143,362,713 Size: 9,314 Total Exon Count: 7 Strand: -
Coding Region
   Position: hg38 chr7:143,356,550-143,362,603 Size: 6,054 Coding Exon Count: 7 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
PathwaysOther NamesMethods
Data last updated at UCSC: 2023-08-18 00:09:47

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr7:143,353,400-143,362,713)mRNA (may differ from genome)Protein (360 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGencodeGeneCards
HGNCHPRDLynxMalacardsMGIneXtProt
PubMedReactomeUniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: F131B_HUMAN
DESCRIPTION: RecName: Full=Protein FAM131B;
SIMILARITY: Belongs to the FAM131 family.
SEQUENCE CAUTION: Sequence=AAS07501.1; Type=Erroneous gene model prediction;

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 48.05 RPKM in Brain - Cerebellar Hemisphere
Total median expression: 272.14 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -61.00110-0.555 Picture PostScript Text
3' UTR -1237.103150-0.393 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR026782 - FAM131

ModBase Predicted Comparative 3D Structure on Q86XD5
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
MGIRGD    
Protein SequenceProtein Sequence    
AlignmentAlignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005515 protein binding

Cellular Component:
GO:0005654 nucleoplasm
GO:0005829 cytosol


-  Descriptions from all associated GenBank mRNAs
  LF207108 - JP 2014500723-A/14611: Polycomb-Associated Non-Coding RNAs.
MA442685 - JP 2018138019-A/14611: Polycomb-Associated Non-Coding RNAs.
BC045611 - Homo sapiens family with sequence similarity 131, member B, mRNA (cDNA clone MGC:33745 IMAGE:5300056), complete cds.
AB018316 - Homo sapiens KIAA0773 mRNA for KIAA0773 protein.
AK124557 - Homo sapiens cDNA FLJ42566 fis, clone BRACE3007480.
AL832579 - Homo sapiens mRNA; cDNA DKFZp451F1416 (from clone DKFZp451F1416); complete cds.
JD440614 - Sequence 421638 from Patent EP1572962.
JD312348 - Sequence 293372 from Patent EP1572962.
JD426067 - Sequence 407091 from Patent EP1572962.
JD162910 - Sequence 143934 from Patent EP1572962.
JD385000 - Sequence 366024 from Patent EP1572962.
JD551669 - Sequence 532693 from Patent EP1572962.
JD083584 - Sequence 64608 from Patent EP1572962.
JD235393 - Sequence 216417 from Patent EP1572962.
JD547204 - Sequence 528228 from Patent EP1572962.
JD163313 - Sequence 144337 from Patent EP1572962.
BC050543 - Homo sapiens family with sequence similarity 131, member B, mRNA (cDNA clone MGC:57625 IMAGE:5768309), complete cds.
JD410008 - Sequence 391032 from Patent EP1572962.
JD077592 - Sequence 58616 from Patent EP1572962.
JD165048 - Sequence 146072 from Patent EP1572962.
JD465354 - Sequence 446378 from Patent EP1572962.
JD332670 - Sequence 313694 from Patent EP1572962.
JD098204 - Sequence 79228 from Patent EP1572962.
JD147579 - Sequence 128603 from Patent EP1572962.
JD163441 - Sequence 144465 from Patent EP1572962.
JD420591 - Sequence 401615 from Patent EP1572962.
JD282373 - Sequence 263397 from Patent EP1572962.
JD224247 - Sequence 205271 from Patent EP1572962.
JD050045 - Sequence 31069 from Patent EP1572962.
JD232804 - Sequence 213828 from Patent EP1572962.
JD241010 - Sequence 222034 from Patent EP1572962.
JD527631 - Sequence 508655 from Patent EP1572962.
JD045101 - Sequence 26125 from Patent EP1572962.
JD381061 - Sequence 362085 from Patent EP1572962.
JD402884 - Sequence 383908 from Patent EP1572962.
JD352833 - Sequence 333857 from Patent EP1572962.
JD367785 - Sequence 348809 from Patent EP1572962.
JD065897 - Sequence 46921 from Patent EP1572962.
JD043854 - Sequence 24878 from Patent EP1572962.
JD236863 - Sequence 217887 from Patent EP1572962.
JD065827 - Sequence 46851 from Patent EP1572962.
JD225513 - Sequence 206537 from Patent EP1572962.
JD219311 - Sequence 200335 from Patent EP1572962.
JD289340 - Sequence 270364 from Patent EP1572962.
JD397547 - Sequence 378571 from Patent EP1572962.
JD560127 - Sequence 541151 from Patent EP1572962.
JD222435 - Sequence 203459 from Patent EP1572962.
JD064783 - Sequence 45807 from Patent EP1572962.
JD067549 - Sequence 48573 from Patent EP1572962.
JD405674 - Sequence 386698 from Patent EP1572962.
JD556633 - Sequence 537657 from Patent EP1572962.
JD091569 - Sequence 72593 from Patent EP1572962.
JD239529 - Sequence 220553 from Patent EP1572962.
JD131692 - Sequence 112716 from Patent EP1572962.
JD126774 - Sequence 107798 from Patent EP1572962.
JD519331 - Sequence 500355 from Patent EP1572962.
JD452536 - Sequence 433560 from Patent EP1572962.
LF361986 - JP 2014500723-A/169489: Polycomb-Associated Non-Coding RNAs.
MA597563 - JP 2018138019-A/169489: Polycomb-Associated Non-Coding RNAs.
JD088374 - Sequence 69398 from Patent EP1572962.
JD559605 - Sequence 540629 from Patent EP1572962.
JD104159 - Sequence 85183 from Patent EP1572962.
JD433893 - Sequence 414917 from Patent EP1572962.
JD439438 - Sequence 420462 from Patent EP1572962.
JD237865 - Sequence 218889 from Patent EP1572962.
JD222683 - Sequence 203707 from Patent EP1572962.
JD178403 - Sequence 159427 from Patent EP1572962.
JD138756 - Sequence 119780 from Patent EP1572962.
JD522572 - Sequence 503596 from Patent EP1572962.
JD227479 - Sequence 208503 from Patent EP1572962.
JD200401 - Sequence 181425 from Patent EP1572962.
JD483060 - Sequence 464084 from Patent EP1572962.
JD470104 - Sequence 451128 from Patent EP1572962.
JD260124 - Sequence 241148 from Patent EP1572962.
JD490914 - Sequence 471938 from Patent EP1572962.
JD372082 - Sequence 353106 from Patent EP1572962.
JD203660 - Sequence 184684 from Patent EP1572962.
LF361987 - JP 2014500723-A/169490: Polycomb-Associated Non-Coding RNAs.
MA597564 - JP 2018138019-A/169490: Polycomb-Associated Non-Coding RNAs.
JD218587 - Sequence 199611 from Patent EP1572962.
JD540132 - Sequence 521156 from Patent EP1572962.
LF361988 - JP 2014500723-A/169491: Polycomb-Associated Non-Coding RNAs.
MA597565 - JP 2018138019-A/169491: Polycomb-Associated Non-Coding RNAs.
JD285319 - Sequence 266343 from Patent EP1572962.
JD145476 - Sequence 126500 from Patent EP1572962.
JD510292 - Sequence 491316 from Patent EP1572962.
JD518725 - Sequence 499749 from Patent EP1572962.
JD092761 - Sequence 73785 from Patent EP1572962.
JD049327 - Sequence 30351 from Patent EP1572962.
JD116302 - Sequence 97326 from Patent EP1572962.
AK291470 - Homo sapiens cDNA FLJ77307 complete cds.
JD415885 - Sequence 396909 from Patent EP1572962.
KJ898078 - Synthetic construct Homo sapiens clone ccsbBroadEn_07472 FAM131B gene, encodes complete protein.
CU692276 - Synthetic construct Homo sapiens gateway clone IMAGE:100020892 5' read FAM131B mRNA.
AB384523 - Synthetic construct DNA, clone: pF1KA0773, Homo sapiens FAM131B gene for FAM131B protein, complete cds, without stop codon, in Flexi system.
LF361989 - JP 2014500723-A/169492: Polycomb-Associated Non-Coding RNAs.
MA597566 - JP 2018138019-A/169492: Polycomb-Associated Non-Coding RNAs.
JD401479 - Sequence 382503 from Patent EP1572962.
LF212025 - JP 2014500723-A/19528: Polycomb-Associated Non-Coding RNAs.
MA447602 - JP 2018138019-A/19528: Polycomb-Associated Non-Coding RNAs.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q86XD5 (Reactome details) participates in the following event(s):

R-HSA-6802927 BRAF and RAF fusion mutant dimers are phosphorylated
R-HSA-6802934 p-BRAF and RAF fusion dimers bind MAP2Ks and MAPKs
R-HSA-6802932 Dissociation of BRAF/RAF fusion complex
R-HSA-6802933 p-BRAF and RAF fusion dimers phosphorylate MAP2Ks
R-HSA-6802935 MAPKs are phosphorylated downstream of BRAF and RAF fusion dimers
R-HSA-6802952 Signaling by BRAF and RAF fusions
R-HSA-6802957 Oncogenic MAPK signaling
R-HSA-5663202 Diseases of signal transduction
R-HSA-1643685 Disease

-  Other Names for This Gene
  Alternate Gene Symbols: A4D2H6, A8K605, B8ZZN2, D3DXE3, ENST00000443739.1, ENST00000443739.2, ENST00000443739.3, ENST00000443739.4, ENST00000443739.5, ENST00000443739.6, F131B_HUMAN, KIAA0773, NM_001031690, Q7L0D6, Q86T97, Q86XD5, uc010lpa.1, uc010lpa.2, uc010lpa.3, uc010lpa.4, uc010lpa.5
UCSC ID: ENST00000443739.7
RefSeq Accession: NM_001031690
Protein: Q86XD5 (aka F131B_HUMAN)
CCDS: CCDS47734.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.