The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q86XD5
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
LF207108 - JP 2014500723-A/14611: Polycomb-Associated Non-Coding RNAs. MA442685 - JP 2018138019-A/14611: Polycomb-Associated Non-Coding RNAs. BC045611 - Homo sapiens family with sequence similarity 131, member B, mRNA (cDNA clone MGC:33745 IMAGE:5300056), complete cds. AB018316 - Homo sapiens KIAA0773 mRNA for KIAA0773 protein. AK124557 - Homo sapiens cDNA FLJ42566 fis, clone BRACE3007480. AL832579 - Homo sapiens mRNA; cDNA DKFZp451F1416 (from clone DKFZp451F1416); complete cds. JD440614 - Sequence 421638 from Patent EP1572962. JD312348 - Sequence 293372 from Patent EP1572962. JD426067 - Sequence 407091 from Patent EP1572962. JD162910 - Sequence 143934 from Patent EP1572962. JD385000 - Sequence 366024 from Patent EP1572962. JD551669 - Sequence 532693 from Patent EP1572962. JD083584 - Sequence 64608 from Patent EP1572962. JD235393 - Sequence 216417 from Patent EP1572962. JD547204 - Sequence 528228 from Patent EP1572962. JD163313 - Sequence 144337 from Patent EP1572962. BC050543 - Homo sapiens family with sequence similarity 131, member B, mRNA (cDNA clone MGC:57625 IMAGE:5768309), complete cds. JD410008 - Sequence 391032 from Patent EP1572962. JD077592 - Sequence 58616 from Patent EP1572962. JD165048 - Sequence 146072 from Patent EP1572962. JD465354 - Sequence 446378 from Patent EP1572962. JD332670 - Sequence 313694 from Patent EP1572962. JD098204 - Sequence 79228 from Patent EP1572962. JD147579 - Sequence 128603 from Patent EP1572962. JD163441 - Sequence 144465 from Patent EP1572962. JD420591 - Sequence 401615 from Patent EP1572962. JD282373 - Sequence 263397 from Patent EP1572962. JD224247 - Sequence 205271 from Patent EP1572962. JD050045 - Sequence 31069 from Patent EP1572962. JD232804 - Sequence 213828 from Patent EP1572962. JD241010 - Sequence 222034 from Patent EP1572962. JD527631 - Sequence 508655 from Patent EP1572962. JD045101 - Sequence 26125 from Patent EP1572962. JD381061 - Sequence 362085 from Patent EP1572962. JD402884 - Sequence 383908 from Patent EP1572962. JD352833 - Sequence 333857 from Patent EP1572962. JD367785 - Sequence 348809 from Patent EP1572962. JD065897 - Sequence 46921 from Patent EP1572962. JD043854 - Sequence 24878 from Patent EP1572962. JD236863 - Sequence 217887 from Patent EP1572962. JD065827 - Sequence 46851 from Patent EP1572962. JD225513 - Sequence 206537 from Patent EP1572962. JD219311 - Sequence 200335 from Patent EP1572962. JD289340 - Sequence 270364 from Patent EP1572962. JD397547 - Sequence 378571 from Patent EP1572962. JD560127 - Sequence 541151 from Patent EP1572962. JD222435 - Sequence 203459 from Patent EP1572962. JD064783 - Sequence 45807 from Patent EP1572962. JD067549 - Sequence 48573 from Patent EP1572962. JD405674 - Sequence 386698 from Patent EP1572962. JD556633 - Sequence 537657 from Patent EP1572962. JD091569 - Sequence 72593 from Patent EP1572962. JD239529 - Sequence 220553 from Patent EP1572962. JD131692 - Sequence 112716 from Patent EP1572962. JD126774 - Sequence 107798 from Patent EP1572962. JD519331 - Sequence 500355 from Patent EP1572962. JD452536 - Sequence 433560 from Patent EP1572962. LF361986 - JP 2014500723-A/169489: Polycomb-Associated Non-Coding RNAs. MA597563 - JP 2018138019-A/169489: Polycomb-Associated Non-Coding RNAs. JD088374 - Sequence 69398 from Patent EP1572962. JD559605 - Sequence 540629 from Patent EP1572962. JD104159 - Sequence 85183 from Patent EP1572962. JD433893 - Sequence 414917 from Patent EP1572962. JD439438 - Sequence 420462 from Patent EP1572962. JD237865 - Sequence 218889 from Patent EP1572962. JD222683 - Sequence 203707 from Patent EP1572962. JD178403 - Sequence 159427 from Patent EP1572962. JD138756 - Sequence 119780 from Patent EP1572962. JD522572 - Sequence 503596 from Patent EP1572962. JD227479 - Sequence 208503 from Patent EP1572962. JD200401 - Sequence 181425 from Patent EP1572962. JD483060 - Sequence 464084 from Patent EP1572962. JD470104 - Sequence 451128 from Patent EP1572962. JD260124 - Sequence 241148 from Patent EP1572962. JD490914 - Sequence 471938 from Patent EP1572962. JD372082 - Sequence 353106 from Patent EP1572962. JD203660 - Sequence 184684 from Patent EP1572962. LF361987 - JP 2014500723-A/169490: Polycomb-Associated Non-Coding RNAs. MA597564 - JP 2018138019-A/169490: Polycomb-Associated Non-Coding RNAs. JD218587 - Sequence 199611 from Patent EP1572962. JD540132 - Sequence 521156 from Patent EP1572962. LF361988 - JP 2014500723-A/169491: Polycomb-Associated Non-Coding RNAs. MA597565 - JP 2018138019-A/169491: Polycomb-Associated Non-Coding RNAs. JD285319 - Sequence 266343 from Patent EP1572962. JD145476 - Sequence 126500 from Patent EP1572962. JD510292 - Sequence 491316 from Patent EP1572962. JD518725 - Sequence 499749 from Patent EP1572962. JD092761 - Sequence 73785 from Patent EP1572962. JD049327 - Sequence 30351 from Patent EP1572962. JD116302 - Sequence 97326 from Patent EP1572962. AK291470 - Homo sapiens cDNA FLJ77307 complete cds. JD415885 - Sequence 396909 from Patent EP1572962. KJ898078 - Synthetic construct Homo sapiens clone ccsbBroadEn_07472 FAM131B gene, encodes complete protein. CU692276 - Synthetic construct Homo sapiens gateway clone IMAGE:100020892 5' read FAM131B mRNA. AB384523 - Synthetic construct DNA, clone: pF1KA0773, Homo sapiens FAM131B gene for FAM131B protein, complete cds, without stop codon, in Flexi system. LF361989 - JP 2014500723-A/169492: Polycomb-Associated Non-Coding RNAs. MA597566 - JP 2018138019-A/169492: Polycomb-Associated Non-Coding RNAs. JD401479 - Sequence 382503 from Patent EP1572962. LF212025 - JP 2014500723-A/19528: Polycomb-Associated Non-Coding RNAs. MA447602 - JP 2018138019-A/19528: Polycomb-Associated Non-Coding RNAs.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein Q86XD5 (Reactome details) participates in the following event(s):
R-HSA-6802927 BRAF and RAF fusion mutant dimers are phosphorylated R-HSA-6802934 p-BRAF and RAF fusion dimers bind MAP2Ks and MAPKs R-HSA-6802932 Dissociation of BRAF/RAF fusion complex R-HSA-6802933 p-BRAF and RAF fusion dimers phosphorylate MAP2Ks R-HSA-6802935 MAPKs are phosphorylated downstream of BRAF and RAF fusion dimers R-HSA-6802952 Signaling by BRAF and RAF fusions R-HSA-6802957 Oncogenic MAPK signaling R-HSA-5663202 Diseases of signal transduction R-HSA-1643685 Disease