Human Gene CLCN6 (ENST00000312413.10) from GENCODE V44
Description: Homo sapiens chloride voltage-gated channel 6 (CLCN6), transcript variant 2, mRNA. (from RefSeq NM_001256959) RefSeq Summary (NR_046428): This gene encodes a member of the voltage-dependent chloride channel protein family. Members of this family can function as either chloride channels or antiporters. This protein is primarily localized to late endosomes and functions as a chloride/proton antiporter. Alternate splicing results in both coding and non-coding variants. Additional alternately spliced variants have been described but their full-length structure is unknown. [provided by RefSeq, Mar 2012]. Gencode Transcript: ENST00000312413.10 Gencode Gene: ENSG00000011021.23 Transcript (Including UTRs) Position: hg38 chr1:11,806,096-11,843,143 Size: 37,048 Total Exon Count: 22 Strand: + Coding Region Position: hg38 chr1:11,806,263-11,840,223 Size: 33,961 Coding Exon Count: 22
ID:CLCN6_HUMAN DESCRIPTION: RecName: Full=Chloride transport protein 6; AltName: Full=Chloride channel protein 6; Short=ClC-6; FUNCTION: Chloride transport protein, initially identified as voltage-gated chloride channel. The presence of the conserved gating glutamate residues suggests that is functions as antiporter. SUBCELLULAR LOCATION: Endosome membrane; Multi-pass membrane protein. Note=Detected in detergent-resistant lipid rafts. TISSUE SPECIFICITY: Testis, ovary, small intestine, brain and skeletal muscle. Low level expression in aortic and coronary vascular smooth muscle cells, and aortic endothelial cells. Isoform C is only detected in kidney. PTM: N-glycosylated on several asparagine residues. MISCELLANEOUS: The CLC channel family contains both chloride channels and proton-coupled anion transporters that exchange chloride or another anion for protons. The presence of conserved gating glutamate residues is typical for family members that function as antiporters (By similarity). SIMILARITY: Belongs to the chloride channel (TC 2.A.49) family. ClC-6/CLCN6 subfamily. SIMILARITY: Contains 2 CBS domains.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF00571 - CBS domain PF00654 - Voltage gated chloride channel
ModBase Predicted Comparative 3D Structure on P51797
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
