Human Gene AHCYL1 (ENST00000393614.8) from GENCODE V44
Description: Homo sapiens adenosylhomocysteinase like 1 (AHCYL1), transcript variant 3, mRNA. (from RefSeq NM_001242674) RefSeq Summary (NM_001242673): The protein encoded by this gene interacts with inositol 1,4,5-trisphosphate receptor, type 1 and may be involved in the conversion of S-adenosyl-L-homocysteine to L-homocysteine and adenosine. Several transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jun 2011]. Gencode Transcript: ENST00000393614.8 Gencode Gene: ENSG00000168710.18 Transcript (Including UTRs) Position: hg38 chr1:109,984,765-110,023,741 Size: 38,977 Total Exon Count: 17 Strand: + Coding Region Position: hg38 chr1:110,009,055-110,021,680 Size: 12,626 Coding Exon Count: 16
ID:SAHH2_HUMAN DESCRIPTION: RecName: Full=Putative adenosylhomocysteinase 2; Short=AdoHcyase 2; EC=3.3.1.1; AltName: Full=DC-expressed AHCY-like molecule; AltName: Full=S-adenosyl-L-homocysteine hydrolase 2; AltName: Full=S-adenosylhomocysteine hydrolase-like protein 1; CATALYTIC ACTIVITY: S-adenosyl-L-homocysteine + H(2)O = L- homocysteine + adenosine. COFACTOR: Binds 1 NAD per subunit. PATHWAY: Amino-acid biosynthesis; L-homocysteine biosynthesis; L- homocysteine from S-adenosyl-L-homocysteine: step 1/1. SUBUNIT: Interacts with ITPR1. Competes with IP3 for interaction with ITPR1 and attenuates IP3-induced Ca(2+) release through the ITPR1 from the non-mitochondrial intracellular stores (By similarity). INTERACTION: P04608:tat (xeno); NbExp=5; IntAct=EBI-2371423, EBI-6164389; SUBCELLULAR LOCATION: Endoplasmic reticulum (By similarity). TISSUE SPECIFICITY: Expressed in dendritic cells. DEVELOPMENTAL STAGE: Expression increases markedly during activation of blood and skin DC (Langerhans cells), but is diminished in terminally differentiated tonsil DC. DOMAIN: The PEST region is essential for the interaction with ITPR1. The PDZ-binding region is required for maximal interaction with ITPR1 and is also responsible for the IP3-insensitive interaction with ITPR1 (By similarity). SIMILARITY: Belongs to the adenosylhomocysteinase family. SEQUENCE CAUTION: Sequence=AAC01960.1; Type=Erroneous initiation; Sequence=BI460083; Type=Frameshift; Positions=Several; Sequence=CAB43223.2; Type=Erroneous initiation;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on O43865
Front
Top
Side
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0006378 mRNA polyadenylation GO:0006611 protein export from nucleus GO:0006730 one-carbon metabolic process GO:0010765 positive regulation of sodium ion transport GO:0031440 regulation of mRNA 3'-end processing GO:0032412 regulation of ion transmembrane transporter activity GO:0033353 S-adenosylmethionine cycle GO:0038166 angiotensin-activated signaling pathway GO:0042045 epithelial fluid transport GO:0044070 regulation of anion transport GO:0051592 response to calcium ion GO:1903779 regulation of cardiac conduction