Human Gene KIF21B (ENST00000360529.9) from GENCODE V44
Description: Homo sapiens kinesin family member 21B (KIF21B), transcript variant 4, mRNA. (from RefSeq NM_001252103) RefSeq Summary (NM_001252103): This gene encodes a member of the kinesin superfamily. Kinesins are ATP-dependent microtubule-based motor proteins that are involved in the intracellular transport of membranous organelles. Single nucleotide polymorphisms in this gene are associated with inflammatory bowel disease and multiple sclerosis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011]. Gencode Transcript: ENST00000360529.9 Gencode Gene: ENSG00000116852.15 Transcript (Including UTRs) Position: hg38 chr1:200,972,990-201,023,408 Size: 50,419 Total Exon Count: 34 Strand: - Coding Region Position: hg38 chr1:200,973,521-201,023,383 Size: 49,863 Coding Exon Count: 34
ID:KI21B_HUMAN DESCRIPTION: RecName: Full=Kinesin-like protein KIF21B; FUNCTION: Microtubule-binding motor protein probably involved in neuronal dendritic transport. In vitro, has a plus-end directed motor activity (By similarity). SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton (By similarity). SIMILARITY: Belongs to the kinesin-like protein family. SIMILARITY: Contains 1 kinesin-motor domain. SIMILARITY: Contains 7 WD repeats. SEQUENCE CAUTION: Sequence=BAA32294.2; Type=Erroneous initiation;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on O75037
Front
Top
Side
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
AL137395 - Homo sapiens mRNA; cDNA DKFZp434J212 (from clone DKFZp434J212). BC031927 - Homo sapiens kinesin family member 21B, mRNA (cDNA clone IMAGE:4938073), with apparent retained intron. BC078676 - Homo sapiens kinesin family member 21B, mRNA (cDNA clone IMAGE:5141761). AB007918 - Homo sapiens KIAA0449 mRNA for KIAA0449 protein. BC144557 - Homo sapiens kinesin family member 21B, mRNA (cDNA clone MGC:178102 IMAGE:9053085), complete cds. BC137281 - Homo sapiens kinesin family member 21B, mRNA (cDNA clone MGC:168901 IMAGE:9021278), complete cds. JD233227 - Sequence 214251 from Patent EP1572962. JD337118 - Sequence 318142 from Patent EP1572962. KJ902270 - Synthetic construct Homo sapiens clone ccsbBroadEn_11664 KIF21B gene, encodes complete protein. AM177180 - Homo sapiens mRNA for kinesin-like protein KIF21B variant (KIF21B gene). AB527174 - Synthetic construct DNA, clone: pF1KA0449, Homo sapiens KIF21B gene for kinesin family member 21B, without stop codon, in Flexi system. AK131318 - Homo sapiens cDNA FLJ16314 fis, clone SPLEN2030847.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein O75037 (Reactome details) participates in the following event(s):
R-HSA-983266 Kinesins bind microtubules R-HSA-6811426 Retrograde COPI vesicles bind kinesin and microtubules R-HSA-6811423 Retrograde vesicle is tethered at the ER by the NRZ complex and t-SNAREs R-HSA-983189 Kinesins R-HSA-6811434 COPI-dependent Golgi-to-ER retrograde traffic R-HSA-983231 Factors involved in megakaryocyte development and platelet production R-HSA-8856688 Golgi-to-ER retrograde transport R-HSA-109582 Hemostasis R-HSA-6811442 Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-199991 Membrane Trafficking R-HSA-5653656 Vesicle-mediated transport