Human Gene KIF21B (ENST00000360529.9) from GENCODE V44
  Description: Homo sapiens kinesin family member 21B (KIF21B), transcript variant 4, mRNA. (from RefSeq NM_001252103)
RefSeq Summary (NM_001252103): This gene encodes a member of the kinesin superfamily. Kinesins are ATP-dependent microtubule-based motor proteins that are involved in the intracellular transport of membranous organelles. Single nucleotide polymorphisms in this gene are associated with inflammatory bowel disease and multiple sclerosis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011].
Gencode Transcript: ENST00000360529.9
Gencode Gene: ENSG00000116852.15
Transcript (Including UTRs)
   Position: hg38 chr1:200,972,990-201,023,408 Size: 50,419 Total Exon Count: 34 Strand: -
Coding Region
   Position: hg38 chr1:200,973,521-201,023,383 Size: 49,863 Coding Exon Count: 34 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsPathwaysOther NamesMethods
Data last updated at UCSC: 2023-08-18 00:09:47

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr1:200,972,990-201,023,408)mRNA (may differ from genome)Protein (1610 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGencodeGeneCards
HGNCHPRDLynxMalacardsMGIneXtProt
OMIMPubMedReactomeUniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: KI21B_HUMAN
DESCRIPTION: RecName: Full=Kinesin-like protein KIF21B;
FUNCTION: Microtubule-binding motor protein probably involved in neuronal dendritic transport. In vitro, has a plus-end directed motor activity (By similarity).
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton (By similarity).
SIMILARITY: Belongs to the kinesin-like protein family.
SIMILARITY: Contains 1 kinesin-motor domain.
SIMILARITY: Contains 7 WD repeats.
SEQUENCE CAUTION: Sequence=BAA32294.2; Type=Erroneous initiation;

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: KIF21B
Diseases sorted by gene-association score: tukel syndrome (4)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 13.90 RPKM in Brain - Cortex
Total median expression: 162.77 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -5.3025-0.212 Picture PostScript Text
3' UTR -229.60531-0.432 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR019821 - Kinesin_motor_CS
IPR001752 - Kinesin_motor_dom
IPR009053 - Prefoldin
IPR015943 - WD40/YVTN_repeat-like_dom
IPR001680 - WD40_repeat
IPR019775 - WD40_repeat_CS
IPR017986 - WD40_repeat_dom

Pfam Domains:
PF00225 - Kinesin motor domain
PF00400 - WD domain, G-beta repeat

ModBase Predicted Comparative 3D Structure on O75037
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-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologGenome BrowserNo orthologNo ortholog
Gene Details     
Gene Sorter     
MGIRGD Ensembl  
Protein SequenceProtein Sequence Protein Sequence  
AlignmentAlignment Alignment  

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000166 nucleotide binding
GO:0003777 microtubule motor activity
GO:0005524 ATP binding
GO:0008017 microtubule binding
GO:0016887 ATPase activity

Biological Process:
GO:0007018 microtubule-based movement

Cellular Component:
GO:0005737 cytoplasm
GO:0005856 cytoskeleton
GO:0005871 kinesin complex
GO:0005874 microtubule
GO:0030424 axon
GO:0030425 dendrite
GO:0030426 growth cone
GO:0031410 cytoplasmic vesicle
GO:0042995 cell projection


-  Descriptions from all associated GenBank mRNAs
  AL137395 - Homo sapiens mRNA; cDNA DKFZp434J212 (from clone DKFZp434J212).
BC031927 - Homo sapiens kinesin family member 21B, mRNA (cDNA clone IMAGE:4938073), with apparent retained intron.
BC078676 - Homo sapiens kinesin family member 21B, mRNA (cDNA clone IMAGE:5141761).
AB007918 - Homo sapiens KIAA0449 mRNA for KIAA0449 protein.
BC144557 - Homo sapiens kinesin family member 21B, mRNA (cDNA clone MGC:178102 IMAGE:9053085), complete cds.
BC137281 - Homo sapiens kinesin family member 21B, mRNA (cDNA clone MGC:168901 IMAGE:9021278), complete cds.
JD233227 - Sequence 214251 from Patent EP1572962.
JD337118 - Sequence 318142 from Patent EP1572962.
KJ902270 - Synthetic construct Homo sapiens clone ccsbBroadEn_11664 KIF21B gene, encodes complete protein.
AM177180 - Homo sapiens mRNA for kinesin-like protein KIF21B variant (KIF21B gene).
AB527174 - Synthetic construct DNA, clone: pF1KA0449, Homo sapiens KIF21B gene for kinesin family member 21B, without stop codon, in Flexi system.
AK131318 - Homo sapiens cDNA FLJ16314 fis, clone SPLEN2030847.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein O75037 (Reactome details) participates in the following event(s):

R-HSA-983266 Kinesins bind microtubules
R-HSA-6811426 Retrograde COPI vesicles bind kinesin and microtubules
R-HSA-6811423 Retrograde vesicle is tethered at the ER by the NRZ complex and t-SNAREs
R-HSA-983189 Kinesins
R-HSA-6811434 COPI-dependent Golgi-to-ER retrograde traffic
R-HSA-983231 Factors involved in megakaryocyte development and platelet production
R-HSA-8856688 Golgi-to-ER retrograde transport
R-HSA-109582 Hemostasis
R-HSA-6811442 Intra-Golgi and retrograde Golgi-to-ER traffic
R-HSA-199991 Membrane Trafficking
R-HSA-5653656 Vesicle-mediated transport

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000360529.1, ENST00000360529.2, ENST00000360529.3, ENST00000360529.4, ENST00000360529.5, ENST00000360529.6, ENST00000360529.7, ENST00000360529.8, KI21B_HUMAN, KIAA0449, NM_001252103, O75037, Q5T4J3, uc010ppn.1, uc010ppn.2, uc010ppn.3
UCSC ID: ENST00000360529.9
RefSeq Accession: NM_001252103
Protein: O75037 (aka KI21B_HUMAN or K21B_HUMAN)
CCDS: CCDS30965.1, CCDS58056.1, CCDS58054.1, CCDS58055.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.