Human Gene FMN2 (ENST00000319653.14) from GENCODE V44
Description: Homo sapiens formin 2 (FMN2), transcript variant 2, mRNA. (from RefSeq NM_020066) RefSeq Summary (NM_020066): This gene is a member of the formin homology protein family. The encoded protein is thought to have essential roles in organization of the actin cytoskeleton and in cell polarity. This protein mediates the formation of an actin mesh that positions the spindle during oogenesis and also regulates the formation of actin filaments in the nucleus. This protein also forms a perinuclear actin/focal-adhesion system that regulates the shape and position of the nucleus during cell migration. Mutations in this gene have been associated with infertility and also with an autosomal recessive form of intellectual disability (MRT47). Alternatively spliced transcript variants have been identified. [provided by RefSeq, Jul 2017]. Gencode Transcript: ENST00000319653.14 Gencode Gene: ENSG00000155816.21 Transcript (Including UTRs) Position: hg38 chr1:240,091,883-240,475,187 Size: 383,305 Total Exon Count: 18 Strand: + Coding Region Position: hg38 chr1:240,092,110-240,474,154 Size: 382,045 Coding Exon Count: 18
ID:FMN2_HUMAN DESCRIPTION: RecName: Full=Formin-2; TISSUE SPECIFICITY: Expressed almost exclusively in the developing and mature central nervous system. PTM: Phosphorylated upon DNA damage, probably by ATM or ATR. SIMILARITY: Belongs to the formin homology family. Cappuccino subfamily. SIMILARITY: Contains 1 FH1 (formin homology 1) domain. SIMILARITY: Contains 1 FH2 (formin homology 2) domain. SEQUENCE CAUTION: Sequence=AAF72884.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Sequence of unknown origin in the C-terminal part;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9NZ56
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0006974 cellular response to DNA damage stimulus GO:0007275 multicellular organism development GO:0015031 protein transport GO:0016192 vesicle-mediated transport GO:0016344 meiotic chromosome movement towards spindle pole GO:0035556 intracellular signal transduction GO:0040038 polar body extrusion after meiotic divisions GO:0042177 negative regulation of protein catabolic process GO:0043066 negative regulation of apoptotic process GO:0046907 intracellular transport GO:0048477 oogenesis GO:0051017 actin filament bundle assembly GO:0051295 establishment of meiotic spindle localization GO:0051758 homologous chromosome movement towards spindle pole involved in homologous chromosome segregation GO:0070649 formin-nucleated actin cable assembly GO:0071456 cellular response to hypoxia
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